ICU Management & Practice, Volume 22 - Issue 4, 2022 Pancreatic Stone Protein Biomarker for Sepsis, Antimicrobial Resistance and Nosocomial Infections The problem of antimicrobial resistance and the use of a clinical decision score and point-of-care testing biomarkers, such as CRP and PSP, to help solve this problem.  Introduction  Infectious diseases are a public health issue around the world, with bacterial, viral, parasitic, or fungal-rel...

ARTICLES|ONLINE FIRST Effectiveness and durability of BNT162b2 vaccine against hospital and emergency department admissions due to SARS-CoV-2 omicron sub-lineages BA.1 and BA.2 in a large health system in the USA: a test-negative, case-control study Sara Y Tartof, Jeff M Slezak, Laura Puzniak, et al Lancet Respir Med Published:October 07, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00354-X Summary Background The SARS-CoV-2 omicron (B.1.1.529 BA.1) ...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Pharmacokinetic/Pharmacodynamic Principles to Combat Antimicrobial Resistance Pharmacodynamic and pharmacokinetic principles play a central role in antimicrobial dose-optimisation to combat antimicrobial resistance. In the future, research focused on the integration of preclinical and clinical data is paramount. Antimicrobial Resistance in the ICU The use of antimicrobial drugs in the hospital is ve...

ARTICLES|ONLINE FIRST Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study Gennaro Martucci, Matthieu Schmidt, Cara Agerstrand, et al. Lancet Respir Med Published:October 11, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00353-8 Summary Background In patients receiving venovenous (VV) extracorporeal membrane oxygenation (ECMO) packed red blood cell (PRBC) transfusion thresholds are usually hig...

Quality of Life, Costs, Economic Evaluation in ECMO Extracorporeal membrane oxygenation (ECMO) refers to mechanical support in patients for heart or lung function during cardiopulmonary failure. ECMO is used when conventional treatments have failed. As per the international guideline of the Extracorporeal Life Support Organization (ELSO), ECMO should be considered when the estimated mortality risk is about 50% and is mostly indicated when the mortality risk approac...

ARTICLES|ONLINE FIRST Prognostic factors associated with mortality among patients receiving venovenous extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis Alexandre Tran, Shannon M Fernando, Bram Rochwerg, et al. Lancet Respir Med Published: October 10, 2022 DOI: https://doi.org/10.1016/S2213-2600(22)00296-X Summary Background Venovenous extracorporeal membrane oxygenation (ECMO) can be considered for patients with ...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Improving Clinical Outcomes With Early Enteral Nutrition An overview of the benefits of early enteral nutrition, clinical evidence and recommendations, reasons for delayed enteral feeding in critically ill patients and optimal solutions. Early enteral nutrition is proven to improve clinical outcomes and reduce acute care costs. Nutrition clinicians support the belief that enteral nutrition is preferabl...

ARTICLES|ONLINE FIRST The burden of respiratory syncytial virus in healthy term-born infants in Europe: a prospective birth cohort study Joanne G Wildenbeest, Marie-Noëlle Billard, Roy P Zuurbier, et al. Lancet Respir Med Published:November 10, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00414-3 Summary Background Respiratory syncytial virus (RSV) is a major cause of hospitalisation in infants. The burden of RSV infection in healthy term infants ha...

Are Patient Satisfaction Tools Causing Harm to Patients and Physicians? It is routine practice to evaluate patient satisfaction through surveys. Physicians also regularly monitor their aggregate satisfaction scores, and public payors reward those with strong results. These tools and measures are based on the premise that patient satisfaction is an integral element of care, and improving patient experience is an important quality dimension for physicians and healthc...

ARTICLES|ONLINE FIRST In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study Roberto Lorusso, Maria Elena De Piero, Silvia Mariani, et al. Lancet Respir Med Published:November 16, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00403-9 Summary Background Extracorporeal membrane oxygenation (ECMO) has been widely used in patients with ...