Original Investigation  Caring for the Critically Ill Patient June 16, 2023 Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial Giacomo Monti, Nikola Bradić, Matteo Marzaroli, et al JAMA. Published online June 16, 2023. doi:10.1001/jama.2023.10598 Key Points Question  Does continuous administration of meropenem reduce a composite of mortality and emerg...

Editorial  May 21, 2023 Conversations on Goals of Care With Hospitalized, Seriously Ill Patients Douglas B. White, Sarah K. Andersen JAMA. 2023;329(23):2021-2022. doi:10.1001/jama.2023.8970 Goals-of-care conversations between clinicians and patients with serious illness have been shown to improve measures of patient and family well-being, while also decreasing health care costs and high-intensity treatments at the end of life.1,2 Nonetheless, achi...

ORIGINAL ARTICLE Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure Peter J. Blankestijn, Robin W.M. Vernooij, Carinna Hockham, et al N Engl J Med June 16, 2023DOI: 10.1056/NEJMoa2304820 Abstract BACKGROUND Several studies have suggested that patients with kidney failure may benefit from high-dose hemodiafiltration as compared with standard hemodialysis. However, given the limitations of the various published studies, additional d...

Original Investigation  Caring for the Critically Ill Patient May 21, 2023 Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial J. Randall Curtis, Robert Y. Lee, Lyndia C. Brumback, et al JAMA. 2023;329(23):2028-2037. doi:10.1001/jama.2023.8812 Key Points Question  Can a patient-specific, clinician-facing communication-priming intervention (Jumpst...

ARTICLES|ONLINE FIRST Implementation of point-of-care testing of C-reactive protein concentrations to improve antibiotic targeting in respiratory illness in Vietnamese primary care: a pragmatic cluster-randomised controlled trial Nga Thi Thuy Do, Tien Viet Dung Vu, Rachel C Greer, et al. Lancet Infect Dis Published: May 22, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00125-1 Summary Background In previous trials, point-of-care testing of C-reactive...

Conference Reports and Expert Panel Open Access Published: 16 June 2023 ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Grasselli, G., Calfee, C.S., Camporota, L. et al. Intensive Care Med (2023). https://doi.org/10.1007/s00134-023-07050-7

#ISICEM23: Low vs Standard Calorie and Protein Feeding Critical illness requiring organ support is associated with high mortality and prolonged recovery. The acute phase is characterised by anorexia, metabolic disorders, endocrine dysfunction, and hypercatabolism with muscle wasting. Nutritional support is essential during this phase. Calorie and protein deficits have been linked to higher risks of healthcare-associated infections, ICU-acquired weakness, prolonged inva...

Conference Reports and Expert Panel Open Access Published: 16 June 2023 ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Grasselli, G., Calfee, C.S., Camporota, L. et al. Intensive Care Med (2023). https://doi.org/10.1007/s00134-023-07050-7 Domain 6: PEEP and recruitment maneuvers Question 6.1: In patients with ARDS undergoing invasive mechanical ventilation, does ...

EDITORIAL Transcatheter Therapy for Tricuspid Regurgitation — First Act Mathias Orban, Steffen Massberg N Engl J Med 2023; 388:1902-1903DOI: 10.1056/NEJMe2302457 Severe tricuspid regurgitation is associated with impaired quality of life and poor survival.1 The condition is managed medically with diuretic agents; surgery is of limited use, since many patients have a variety of coexisting conditions that increase surgical risk. Current U.S. and European soc...

ICU Management & Practice, Volume 23 - Issue 1, 2023 Biomarkers of Infection in the Intensive Care Unit Biomarkers are an area of rapid discovery in critical care medicine today. They have the potential to improve our ability to identify and manage patients at increased risk of organ failure and death. This article provides an overview of biomarkers of infection in the intensive care unit. The heterogeneity of sepsis makes its identification challenging ...