ARTICLES|ONLINE FIRST Characterisation of SARS-CoV-2 variants in Beijing during 2022: an epidemiological and phylogenetic analysis Yang Pan, Liang Wang, Zhaomin Feng, et al. Lancet Published:February 08, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00129-0 Summary Background Due to the national dynamic zero-COVID strategy in China, there were no persistent local transmissions of SARS-CoV-2 in Beijing before December, 2022. However, imported cases ha...

Editorial  February 7, 2023 Manufacturer Spending on Direct-to-Consumer Advertising for Pharmaceutical Products Amanda Starc JAMA. 2023;329(5):371-373. doi:10.1001/jama.2022.24078 The tension between physicians and drugmakers, especially over marketing, dates to the era of patent medicines.1 Since 1997, pharmaceutical manufacturers have advertised directly to US consumers, amplifying controversy over the role of drug marketing in clinica...

ORIGINAL ARTICLE Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer Nasser Altorki, Xiaofei Wang, David Kozono, et al N Engl J Med 2023; 388:489-498DOI: 10.1056/NEJMoa2212083 Abstract BACKGROUND The increased detection of small-sized peripheral non–small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy. METHODS We conducted a multicenter, noninferiority, phase 3 trial in which...

Original Investigation  January 26, 2023 Household Transmission of Influenza A Viruses in 2021-2022 Melissa A. Rolfes, H. Keipp Talbot, Huong Q. McLean, et al JAMA. Published online January 26, 2023. doi:10.1001/jama.2023.0064 Key Points Question  What is the risk of influenza A(H3N2) virus infection among household contacts of patients diagnosed with influenza during the 2021-2022 season compared with influenza seasons before th...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Multidrug-Resistant Gram-Negative Bacteria in the ICU Severe infections by antibiotic resistant gram-negative bacteria are frequent in ICU patients. They are associated with high morbidity and mortality. Introduction Bacterial infections in patients hospitalised in the Intensive Care Unit (ICU) are frequent, and they elicit an increase in morbidity and mortality. The emerging development of antibiot...

Optimised Prediction of All-Cause Mortality of ICU Patients Outcomes research on ICU patients requires accurate measures of comorbidity to predict mortality. The Simplified Acute Physiology Score (SAPS3) is widely used and provides some information on comorbidity. The Charlson comorbidity index (CCI) uses general comorbidity measures and may not be sufficiently discriminative. These risk scores use the presence of comorbidity as binary variables but disregard quant...

Original Investigation  February 7, 2023 Association Between Drug Characteristics and Manufacturer Spending on Direct-to-Consumer Advertising Michael J. DiStefano, Jenny M. Markell, Caroline C. Doherty, et al JAMA. 2023;329(5):386-392. doi:10.1001/jama.2022.23968 Key Points Question  What drug characteristics are associated with larger proportions of promotional spending allocated to direct-to-consumer advertising? Findings&nb...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Antibiotic Stewardship in Critical and Emergency Care An overview of antimicrobial stewardship in critical care units and emergency departments, highlighting aspects to reduce multidrug resistance focusing on antibiotic optimisation in respiratory infections and sepsis. Introduction Infections caused by resistant bacteria are associated with higher treatment costs and increased morbidity and mortali...

Home High-Flow Nasal Cannula Oxygen Therapy for Stable Hypercapnic COPD: A Randomized Clinical Trial Kazuma Nagata, Takeo Horie, Naohiko Chohnabayashi, et al Am J Respir Crit Care Med 2022 Dec 1;206(11):1326-1335 DOI: 10.1164/rccm.202201-0199OC Abstract Rationale: The long-term effects of using a high-flow nasal cannula for chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease remain unclear. Object...

Original Investigation  November 23, 2022 Safety and Efficacy of Robotic vs Open Liver Resection for Hepatocellular Carcinoma Fabrizio Di Benedetto, Paolo Magistri, Stefano Di Sandro, et al JAMA Surg. Published online November 23, 2022. doi:10.1001/jamasurg.2022.5697 Key Points Question  Is the robotic approach a safe strategy for hepatocellular carcinoma (HCC) resection with good long-term outcomes? Findings  In thi...