於服用口服抗病毒藥的新冠病毒住院患者中，病毒量反彈的風險因素及相關臨床結果: 一項 回顧性隊列研究 ARTICLES|ONLINE FIRST Viral burden rebound in hospitalised patients with COVID-19 receiving oral antivirals in Hong Kong: a population-wide retrospective cohort study Carlos K H Wong, Kristy T K Lau, Ivan C H Au, et al. Lancet Infect Dis Published: February 13, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00873-8 Summary Background Viral rebound after ...

Editorial  February 20, 2023 The Ethics of Clinical Research: Managing Persistent Uncertainty Alex John London, Christopher W. Seymour JAMA. Published online February 20, 2023. doi:10.1001/jama.2023.1675 In the face of novel pathogens, incomplete knowledge, and disagreement about the merits of medical treatments, translating the duty to care into concrete benefits for patients depends on our ability to quickly act on the duty to learn.1 ...

ICU Management & Practice, Volume 22 - Issue 4, 2022 Reducing Antibiotic Resistance in the ICU This article reviews practices currently available to reduce the spread of antimicrobial resistance and novel therapies that are presently being developed. Introduction Among healthcare providers, and especially among those working with intensive care unit (ICU) patients, one of the greatest concerns that has emerged in recent decades has been a steady escal...

ORIGINAL ARTICLE Hydrocortisone in Severe Community-Acquired Pneumonia Pierre-François Dequin, Ferhat Meziani, Jean-Pierre Quenot, et al N Engl J Med March 21, 2023DOI: 10.1056/NEJMoa2215145 Abstract BACKGROUND Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear. METHODS In this phase 3, multicenter, double-blind, randomized, controlle...

Editorials Poorly substantiated health claims on infant formula Nigel Rollins BMJ 2023; 380 doi: https://doi.org/10.1136/bmj.p310 (Published 15 February 2023)Cite this as: BMJ 2023;380:p310 Authorities should move to protect infants and parents from commercial interests Early infant feeding is critically important for the survival, development, and lifelong health of children. It is also a big business. In 2019, global sales of infant formula milks exceeded...

CCBYNC Open accessResearch Effect of a multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for suspected urinary tract infections in frail older adults (ImpresU): pragmatic cluster randomised controlled trial in four European countries Esther A R Hartman, Alma C van de Pol, Silje Rebekka Heltveit-Olsen, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072319 (Published 22 February 2023)Cite this as: BMJ 2023;380:e07231...

JAMA Clinical Guidelines Synopsis  February 16, 2023 Management of Thoracic Aortic Dissection Irbaz Hameed, Adam S. Cifu, Prashanth Vallabhajosyula JAMA. Published online February 16, 2023. doi:10.1001/jama.2023.0265 Guideline titles American Association for Thoracic Surgery Expert Consensus Document: Surgical Treatment of Acute Type A Aortic Dissection; Society of Thoracic Surgeons/American Association for Thoracic Surgery Clinical Prac...

Sepsis in Critical Care The importance of clearly defining sepsis, improving early recognition strategy, and increasing the understanding of innate and adaptive immune system derangements that facilitate the development of sepsis. The improvement in mortality outcomes of patients with sepsis is attributable to the early recognition of sepsis, better adherence to guidelines, and a prompt organisation's responsiveness. However, sepsis remains the leading cause of deat...

Original Investigation  February 20, 2023 Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial Susanna Naggie, David R. Boulware, Christopher J. Lindsell, et al JAMA. Published online February 20, 2023. doi:10.1001/jama.2023.1650 Key Points Question  Does ivermectin, with a maximum targeted dose of 600 μg/kg daily for 6 days, compared with p...

Original Investigation  February 21, 2023 History of Low Hourly Wage and All-Cause Mortality Among Middle-aged Workers Katrina L. Kezios, Peiyi Lu, Sebastian Calonico, et al JAMA. 2023;329(7):561-573. doi:10.1001/jama.2023.0367 Key Points Question  Is a history of sustained low-wage earning during peak midlife earning years associated with elevated mortality risk and excess mortality? Findings  In a longitudinal stud...