ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalDaily point-of-care ultrasound-assessment of central venous catheter-related thrombosis in critically ill patients: a prospective multicenter studyWu C. et al. OPEN ACCESSOptimal oxygen and mean arterial blood pressure targets after cardiac arrestSkrifvars M., Bray J. and Hassager C. Understanding the DiseaseHigh-risk pulmonary embolism in the intensive care unitHelms J., Carrier M. and Klok F.A. Recent adv...

ORIGINAL ARTICLE Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension Marius M. Hoeper, David B. Badesch, H. Ardeschir Ghofrani, et al N Engl J Med March 6, 2023DOI: 10.1056/NEJMoa2213558 Abstract BACKGROUND Pulmonary arterial hypertension is a progressive disease involving proliferative remodeling of the pulmonary vessels. Despite therapeutic advances, the disease-associated morbidity and mortality remain high. Sotatercept is a ...

ICU Management & Practice, Volume 22 - Issue 5, 2022 Improving Haemodynamic Management of ICU Patients: Decatecholaminisation & Cardiac Stress Reduction A summary of a symposium organised by AOP Health with presentations from Ricard Ferrer, Vall d’Hebron University Hospital, Barcelona, Spain; Bruno Levy, Centre Hospitalier Universitaire de Nancy, CHU Nancy · Réanimation Médicale Brabois, France; and Michael Fries, St. Vincenz Krankenhaus Limburg, Depart...

Original Investigation  March 7, 2023 Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death: A Randomized Clinical Trial Anna Roca, Bully Camara, Joel D. Bognini, et al JAMA. 2023;329(9):716-724. doi:10.1001/jama.2022.24388 Key Points Question  Does azithromycin administered orally during labor reduce neonatal sepsis and mortality? Findings  This randomized trial in West Africa included 11 983 bi...

Research Inequities in surgical outcomes by race and sex in the United States: retrospective cohort study Dan P Ly, Mariah B Blegen, Melinda M Gibbons, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-073290 (Published 01 March 2023)Cite this as: BMJ 2023;380:e073290 Abstract Objective To assess inequities in mortality by race and sex for eight common surgical procedures (elective and non-elective) across specialties in the United States. D...

COMMENT|ONLINE FIRST Remdesivir saves lives. Were 3 years needed to learn that? Andre C Kalil Lancet Respir Med Published: February 21, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00036-X In The Lancet Respiratory Medicine, Alain Amstutz and colleagues1address a 3-year-old controversy: does remdesivir reduce mortality in patients hospitalised for COVID-19? Remdesivir is a viral RNA polymerase inhibitor that was evaluated in patients hospitalised for C...

Impact of Fatigue on Anaesthesia Providers Fatigue is being recognised as a workplace hazard of increasing concern. It is a significant problem for anaesthesiologists who have long working hours and irregular schedules. Fatigue negatively impacts vigilance, communication, and teamwork and shows decreased performance during psychomotor testing. However, its impact on real-life performance is uncertain. Fatigue is a complex issue with many definitions proposed in ...

ARTICLES|ONLINE FIRST Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study Samuel Channon-Wells, Ortensia Vito, Andrew J McArdle, et al. Lancet Rheumatol Published:February 14, 2023 DOI:https://doi.org/10.1016/S2665-9913(23)00029-2 Summary Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infe...

COMMENT|ONLINE FIRST Real-world effectiveness of nirmatrelvir–ritonavir against BA.4 and BA.5 omicron SARS-CoV-2 variants Carlos K H Wong, Kristy T K Lau, Gabriel M Leung Lancet Infect Dis Published: February 10, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00056-7 Over the past year of the COVID-19 pandemic, populations worldwide have been facing the constant threat of the SARS-CoV-2 omicron variant and its sublineages, and the high transmissibility and ...

ARTICLES|ONLINE FIRST Long-term effectiveness of COVID-19 vaccines against infections, hospitalisations, and mortality in adults: findings from a rapid living systematic evidence synthesis and meta-analysis up to December, 2022 Nana Wu, Keven Joyal-Desmarais, Paula A B Ribeiro, et al. Lancet Respir Med Published: February 10, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00015-2 Summary Background Synthesising evidence on the long-term vaccine effect...