Editorial  March 21, 2023 Toward Personalizing Care: Assessing Heterogeneity of Treatment Effects in Randomized Trials Issa J. Dahabreh, Dhruv S. Kazi JAMA. Published online March 21, 2023. doi:10.1001/jama.2023.3576 Clinicians know that individual patients may respond differently to a given treatment and that the overall treatment effect reported in a randomized trial of the treatment may not be directly applicable to all patients in clinica...

Original Investigation  Caring for the Critically Ill Patient March 21, 2023 Heterogeneous Treatment Effects of Therapeutic-Dose Heparin in Patients Hospitalized for COVID-19 Ewan C. Goligher, Patrick R. Lawler, Thomas P. Jensen, et al JAMA. Published online March 21, 2023. doi:10.1001/jama.2023.3651 Key Points Question  What patient characteristics are associated with benefit or harm of therapeutic-dose heparin in patients ho...

ARTICLES|ONLINE FIRST Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:April 12, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00510-X Summary Background Low-dose corticosteroids have been shown to reduce mortality for patients with COVID-19 requiring oxygen or vent...

Time to Move From SOFA 1.0 to 2.0? The Sequential Organ Failure Assessment (SOFA) score was developed in 1994, more than 25 years ago. The primary purpose of the score was to provide clinicians with a method that could help them assess and monitor organ dysfunction in critically ill patients. SOFA score became one of the most widely used scoring systems in intensive care. However, many changes have occurred in clinical practice over the last decades. New interventi...

Guidelines Open Access Published: 01 March 2023 The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition Rolf Rossaint, Arash Afshari, Bertil Bouillon, et al Crit Care 2023; 27: 80 I. Initial resuscitation and prevention of further bleeding Minimal elapsed time Recommendation 1 We recommend that severely injured patients be transported directly to an appropriate trauma facility (Grade 1B...

Research Comparison of mental health symptoms before and during the covid-19 pandemic: evidence from a systematic review and meta-analysis of 134 cohorts Ying Sun, Yin Wu, Suiqiong Fan, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-074224 (Published 08 March 2023)Cite this as: BMJ 2023;380:e074224 Abstract Objective To synthesise results of mental health outcomes in cohorts before and during the covid-19 pandemic. Design Systematic ...

Measuring Global Response to Antimicrobial Resistance In order to evaluate current progress and future planning to overcome antimicrobial resistance, it is important to understand strategic commitments and policy responses. The most important mechanism guiding national strategy and action for antimicrobial resistance governance is the national action plans (NAPs). Several NAPs have been developed, but to date, there has been no comprehensive analysis of these plans...

Research Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records Yan Xie, Benjamin Bowe, Ziyad Al-Aly BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-072705 (Published 07 March 2023)Cite this as: BMJ 2023;380:e072705 Abstract Objective To emulate a randomized target trial to estimate the association between the antiviral drug molnupiravir and hospital admis...

ARTICLES|ONLINE FIRST Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study James Peter Allinson, Nishi Chaturvedi, Andrew Wong, et al. Lancet Published:March 07, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00131-9 Summary Background Lower respiratory tract infections (LRTIs) in early childhood are known to influence lung development and lifelong lung hea...

EDITORIAL Continued Progress in Therapy for Pulmonary Arterial Hypertension Darren B. Taichman, Jane A. Leopold, Greg Elliott N Engl J Med March 6, 2023DOI: 10.1056/NEJMe2300324 Pulmonary arterial hypertension is a devastating disorder characterized by precapillary pulmonary hypertension not caused by respiratory disease, obstruction of the pulmonary arteries, or certain less-common conditions. Idiopathic pulmonary arterial hypertension, heritable pulmonary ar...