Research Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial Peter S Blair, Grace Young, Clare Clement, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-072488 (Published 26 April 2023)Cite this as: BMJ 2023;381:e072488 Abstract Objective To assess whether an easy-to-use multifaceted interv...

Invited Commentary  April 28, 2023 How Chatbots and Large Language Model Artificial Intelligence Systems Will Reshape Modern Medicine: Fountain of Creativity or Pandora’s Box? Ron Li, Andre Kumar, Jonathan H. Chen JAMA Intern Med. Published online April 28, 2023. doi:10.1001/jamainternmed.2023.1835 In an era of clinicians being burnt out by electronic medical records and documentation burdens, we might all dream of having a personal scribe to...

Original Investigation  April 28, 2023 Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum John W. Ayers, Adam Poliak, Mark Dredze, et al JAMA Intern Med. Published online April 28, 2023. doi:10.1001/jamainternmed.2023.1838 Key Points Question  Can an artificial intelligence chatbot assistant, provide responses to patient questions that are of comparable qua...

ICU Management & Practice, Volume 22 - Issue 5, 2022 Guiding Clinical Care Using Pancreatic Stone Protein The role of point-of-care testing in the early identification and management of sepsis, the need for better markers to identify sepsis, an overview of the Pancreatic Stone Protein (PSP) and clinical evidence highlighting its effectiveness as a biomarker. Pancreatic Stone Protein Infections are a leading cause of morbidity and mortality among criti...

ARTICLES|ONLINE FIRST Effectiveness of handwashing with soap for preventing acute respiratory infections in low-income and middle-income countries: a systematic review and meta-analysis Ian Ross, Sarah Bick, Philip Ayieko, et al Lancet Published:April 27, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00021-1 Summary Background Acute respiratory infection (ARI) is a leading cause of morbidity and mortality globally, with 83% of ARI mortality occurring...

ARTICLES|ONLINE FIRST Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, et al Lancet Microbe Published:April 25, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00041-1 Summary Background The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations be...

EDITORIAL Traumatic Acute Subdural Hematoma — Should the Bone Flap Be Removed or Replaced? Shankar Gopinath N Engl J Med April 23, 2023DOI: 10.1056/NEJMe2302936 Traumatic acute subdural hematomas often warrant emergency evacuation of the blood clot to avoid further cerebral compression and its sequelae. Once the subdural clot is removed, the million-dollar question in the mind of the neurosurgeon is to whether to replace the bone flap (craniotomy) or not (deco...

Safety Outcomes of Direct Discharge From ICU Patients discharged from ICUs are traditionally transferred to a hospital ward to facilitate recovery and rehabilitation and to organise discharge planning. However,  direct discharge home (DDH) from ICUs is becoming more common due to high hospital ward censuses and transfer delays. This increase is mainly due to strained ward capacity and high costs. Prior research shows an inverse correlation between DDH and ICU ...

ORIGINAL ARTICLE Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma Peter J. Hutchinson, Hadie Adams, Midhun Mohan, et al N Engl J Med April 23, 2023DOI: 10.1056/NEJMoa2214172 Abstract BACKGROUND Traumatic acute subdural hematomas frequently warrant surgical evacuation by means of a craniotomy (bone flap replaced) or decompressive craniectomy (bone flap not replaced). Craniectomy may prevent intracranial hypertension, but whether it ...

COMMENT|ONLINE FIRST Guidelines adherence as a major protective aspect to increase survival rate in patients with candidaemia in Europe Mohammad Sadegh Rezai, Fatemeh Ahangarkani Lancet Infect Dis Published:February 15, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00046-4 Despite improvements in medical interventions and new antifungal drugs, candidaemiais widely recognised as a major cause of morbidity and mortality worldwide.1, 2 Not...