Original Investigation  April 26, 2023 Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies Matthew R. Thau, Ted Liu, Neha A. Sathe, et al JAMA Surg. 2023;158(7):728-736. doi:10.1001/jamasurg.2023.0819 Key Points Question  Are trauma molecular endotypes associated with clinical outcomes and differential response to transfusion resuscitation strategies? Findings  In this s...

#ISICEM23: Findings from the PROCOAG Clinical Trial Findings from the PROCOAG randomised clinical trial were presented for the first time during the #ISICEM23 opening. The best way to manage transfusions in traumatic haemorrhage remains unclear. However, there are indications that using a 4-factor prothrombin complex concentrate (4F-PCC) could have a beneficial effect on blood product consumption. The PROCOAG study aimed to evaluate the efficacy and safety of...

Original Investigation  May 24, 2023 Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial Maple Goh, Clare Hollewand, Stephen McBride, et al JAMA Surg. 2023;158(7):718-726. doi:10.1001/jamasurg.2023.1201 Key Points Question  What effect does incision-site injection of microdosed antibiotics have on the rate of surgical site infection (SSI) before skin can...

Original Investigation  August 7, 2023 Effects of Cuff Size on the Accuracy of Blood Pressure Readings: The Cuff(SZ) Randomized Crossover Trial Junichi Ishigami, Jeanne Charleston, Edgar R. Miller III, et al JAMA Intern Med. Published online August 7, 2023. doi:10.1001/jamainternmed.2023.3264 Key Points Question  What is the effect of using a regular size blood pressure (BP) cuff regardless of an individual’s mid-upper arm circum...

Postextubation Noninvasive Respiratory Support in Patients with Acute Brain Injury: Not a Panacea, but Don’t Throw the Baby Out with the Bathwater! Romain Pirracchio and  Alejandro A. Rabinstein Am J Respir Crit Care Med 2023; 208: 225-226 Extubation failure is a common problem in patients with acute brain injury, with rates ranging from 15% to 25% across studies (1–3). Older age, longer duration of mechanical ventilation, and impaired airway protective reflexes ...

ICU Management & Practice, Volume 23 - Issue 1, 2023 Utility of Biomarkers in Obstetric Patients With Preeclampsia Preeclampsia is a complex syndrome whose complications bear an impact on perinatal morbidity and mortality. Angiogenic biomarkers may significantly impact both the decision to admit patients and risk stratification and may also help guide patient management and level of care. Preeclampsia is one of the main causes of maternal and foetal morb...

ARTICLES|ONLINE FIRST Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study Xianming Zhu, Kelly A Gebo, Alison G Abraham, et al Lancet Microbe Published:August 07, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00171-4 Summary Background Cytokines and chemokines play a critical role in the response to infection and vaccination. We aimed to assess the longitudinal association of COVID...

Enhancing the Efficacy of Mesenchymal Stromal Cells in COVID-19–related Acute Respiratory Distress Syndrome Haibo Zhang and  Arthur S. Slutsky Am J Respir Crit Care Med 2023; 208: 222-224 Mesenchymal stromal cells (MSCs) have garnered considerable attention as a potential therapeutic option for patients with acute respiratory distress syndrome (ARDS) because of their capacity to modulate inflammation and promote tissue repair (1, 2). In this editorial, we su...

Research Association between antenatal corticosteroids and risk of serious infection in children Tsung-Chieh Yao, Sheng-Mao Chang, Chi-Shin Wu, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2023-075835 (Published 02 August 2023)Cite this as: BMJ 2023;382:e075835 Abstract Objective To investigate the associations between exposure to antenatal corticosteroids and serious infection in children during the first three, six, and 12 months of life. ...

Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial Ellen A. Gorman,  Jennifer Rynne,  Hannah J. Gardiner, et al Am J Respir Crit Care Med 2023; 208: 256-269 Abstract Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in coronavirus disease (COVID-19)–related acute respiratory distress syndrome (ARDS). Objectives: ...