ORIGINAL ARTICLE Transcatheter Repair for Patients with Tricuspid Regurgitation Paul Sorajja, Brian Whisenant, Nadira Hamid, et al N Engl J Med 2023; 388:1833-1842DOI: 10.1056/NEJMoa2300525 Abstract BACKGROUND Severe tricuspid regurgitation is a debilitating condition that is associated with substantial morbidity and often with poor quality of life. Decreasing tricuspid regurgitation may reduce symptoms and improve clinical outcomes in patients with this...

Editorial  May 9, 2023 The Role of Prophylactic Antibiotics for Patients With Severe Alcohol-Related Hepatitis Ewan Forrest, William Bernal JAMA. 2023;329(18):1552-1553. doi:10.1001/jama.2023.1729 Few effective pharmacologic therapies are available for alcohol-related hepatitis. In patients diagnosed with alcohol-related hepatitis, greater severity of liver injury and systemic inflammation are associated independently with early mortality.1&n...

Original Investigation  May 25, 2023 Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection Tanayott Thaweethai, Sarah E. Jolley, Elizabeth W. Karlson, et al JAMA. Published online May 25, 2023. doi:10.1001/jama.2023.8823 Key Points Question  What symptoms are differentially present in SARS-CoV-2–infected individuals 6 months or more after infection compared with uninfected individuals, and what symptom-based c...

Original Investigation  April 20, 2023 Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial Michael I. D’Angelica, Ryan J. Ellis, Jason B. Liu, et al JAMA. 2023;329(18):1579-1588. doi:10.1001/jama.2023.5728 Key Points Question  Does use of perioperative broad-spectrum antibiotics reduce postoperative surgical site infection after open pancreatoduodenec...

ICU Management & Practice, Volume 23 - Issue 1, 2023 Sepsis Diagnosis: Clinical Signs, Scores, and Biomarkers Abstract Sepsis and antimicrobial resistance are two major public health problems. Sepsis is defined as a dysregulated response of the body to a bacterial infection with organ dysfunction. The 2021 Surviving Sepsis Campaign SSC guidelines proposed characterising the infection based on clinical assessment an...

Original Investigation  May 9, 2023 Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial Alexandre Louvet, Julien Labreuche, Thong Dao, et al JAMA. 2023;329(18):1558-1566. doi:10.1001/jama.2023.4902 Key Points Question  Among patients with severe alcohol-related hepatitis, does the combination of amoxicillin-clavulanate with prednisolon...

Invited Commentary  May 1, 2023 The Disappointing Impact of Interventions to Prevent Hospital Readmissions Robert M. Wachter JAMA Intern Med. Published online May 1, 2023. doi:10.1001/jamainternmed.2023.0804 When it comes to intervention trials in health services research, we are often left with the challenge of interpreting the generalizability of a positive study, particularly when the intervention involved humans interacting with other hum...

European Guidelines: Management of Bleeding, Coagulopathy Following Trauma According to the Global Burden of Diseases, Injuries, and Risk Factors Study, trauma accounted for 8% of total deaths annually. Among adolescents aged 10-24 years, road injuries, self-harm, and interpersonal violence are the top causes of disability-adjusted life-years, and road injuries are ranked first in the 25-49 year age group. Post-traumatic bleeding and associated traumatic coagulopat...

Original Investigation  May 1, 2023 Effects of a Multimodal Transitional Care Intervention in Patients at High Risk of Readmission: The TARGET-READ Randomized Clinical Trial Jacques Donzé, Gregor John, Daniel Genné, et al JAMA Intern Med. Published online May 1, 2023. doi:10.1001/jamainternmed.2023.0791 Key Points Question  Could a transitional care intervention targeting higher-risk medical patients reduce the risk of 30-day unp...

Research Benefits and harms of drug treatment for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials Qingyang Shi, Kailei Nong, Per Olav Vandvik, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-074068 (Published 06 April 2023)Cite this as: BMJ 2023;381:e074068 Abstract Objective To compare the benefits and harms of drug treatments for adults with type 2 diabetes, adding non-steroidal mineralocorticoid...