Original Investigation  June 20, 2023 Evidence of Lack of Treatment Efficacy Derived From Statistically Nonsignificant Results of Randomized Clinical Trials Thomas Perneger, Angèle Gayet-Ageron JAMA. 2023;329(23):2050-2056. doi:10.1001/jama.2023.8549 Key Points Question  Can a statistically nonsignificant result of a randomized clinical trial provide conclusive evidence of lack of effect of the new treatment? Findings &nb...

Perspective Toward Comprehensive Care for Long Covid Janko Ž. Nikolich, Clifford J. Rosen N Engl J Med May 9, 2023DOI: 10.1056/NEJMp2304550 Three years into the Covid pandemic, SARS-CoV-2 is still with us. As the virus evolves, it continues to pose a health threat in terms of both acute infections (or reinfections) and postacute sequelae. In regard to the former, there is evidence that several pharmacologic interventions reduce the severity of infections, less...

Editorial  June 16, 2023 Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis? Claire N. Shappell, Michael Klompas, Chanu Rhee JAMA. Published online June 16, 2023. doi:10.1001/jama.2023.6483 There has been a concerted effort over the past 2 decades to improve sepsis outcomes by enhancing recognition of sepsis and decreasing the time to administration of appropriate antibiotics.1 Sepsis m...

ORIGINAL ARTICLE Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults Matthew E. Prekker, Brian E. Driver, Stacy A. Trent, et al N Engl J Med June 16, 2023DOI: 10.1056/NEJMoa2301601 Abstract BACKGROUND Whether video laryngoscopy as compared with direct laryngoscopy increases the likelihood of successful tracheal intubation on the first attempt among critically ill adults is uncertain. METHODS In a multicenter, randomize...

Original Investigation  Caring for the Critically Ill Patient June 16, 2023 Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial Giacomo Monti, Nikola Bradić, Matteo Marzaroli, et al JAMA. Published online June 16, 2023. doi:10.1001/jama.2023.10598 Key Points Question  Does continuous administration of meropenem reduce a composite of mortality and emerg...

Editorial  May 21, 2023 Conversations on Goals of Care With Hospitalized, Seriously Ill Patients Douglas B. White, Sarah K. Andersen JAMA. 2023;329(23):2021-2022. doi:10.1001/jama.2023.8970 Goals-of-care conversations between clinicians and patients with serious illness have been shown to improve measures of patient and family well-being, while also decreasing health care costs and high-intensity treatments at the end of life.1,2 Nonetheless, achi...

ORIGINAL ARTICLE Effect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure Peter J. Blankestijn, Robin W.M. Vernooij, Carinna Hockham, et al N Engl J Med June 16, 2023DOI: 10.1056/NEJMoa2304820 Abstract BACKGROUND Several studies have suggested that patients with kidney failure may benefit from high-dose hemodiafiltration as compared with standard hemodialysis. However, given the limitations of the various published studies, additional d...

Original Investigation  Caring for the Critically Ill Patient May 21, 2023 Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial J. Randall Curtis, Robert Y. Lee, Lyndia C. Brumback, et al JAMA. 2023;329(23):2028-2037. doi:10.1001/jama.2023.8812 Key Points Question  Can a patient-specific, clinician-facing communication-priming intervention (Jumpst...

ARTICLES|ONLINE FIRST Implementation of point-of-care testing of C-reactive protein concentrations to improve antibiotic targeting in respiratory illness in Vietnamese primary care: a pragmatic cluster-randomised controlled trial Nga Thi Thuy Do, Tien Viet Dung Vu, Rachel C Greer, et al. Lancet Infect Dis Published: May 22, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00125-1 Summary Background In previous trials, point-of-care testing of C-reactive...

Conference Reports and Expert Panel Open Access Published: 16 June 2023 ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Grasselli, G., Calfee, C.S., Camporota, L. et al. Intensive Care Med (2023). https://doi.org/10.1007/s00134-023-07050-7