ARTICLES|ONLINE FIRST Performance of antigen lateral flow devices in the UK during the alpha, delta, and omicron waves of the SARS-CoV-2 pandemic: a diagnostic and observational study David W Eyre, Matthias Futschik, Sarah Tunkel, et al Lancet Infect Dis Published:March 28, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00129-9 Summary Background Antigen lateral flow devices (LFDs) have been widely used to control SARS-CoV-2. We aimed to improve under...

Early Tracheostomy vs Late Tracheostomy in Traumatic Brain Injury, Stroke A recent review aimed to determine whether early tracheostomy benefits patients with severe traumatic brain injury (TBI) and stroke and whether these benefits persist across different underlying conditions. The included studies in the review were those written in English, French, Spanish, or Portuguese and with a formulated question that compared outcomes between early and late tracheostom...

ARTICLES| VOLUME 23, ISSUE 5, P589-597, MAY 2023 Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study Douglas L Fink, Helen Callaby, Akish Luintel, et al. Lancet Infect Dis 2023; 23: 589-597 Published:December 22, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00806-4 Summary Background The scale of the 2022 global mpox (formerly know...

ARTICLES| VOLUME 23, ISSUE 5, P556-567, MAY 2023 Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression Niklas Bobrovitz, Harriet Ware, Xiaomeng Ma, et al. Lancet Infect Dis 2023; 23: 556-567 Published:January 18, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00801-5 Summary Background The global surge in the omicron (B.1.1.529) variant has ...

Determining Brain Death The Uniform Law Commission (ULC) created the Uniform Determination of Death Act (UDDA) in the United States in 1980, which was adopted by all 50 states. The UDDA defines death as either the irreversible cessation of circulatory and respiratory functions or the irreversible cessation of all functions of the entire brain, including the brainstem. While the loss of cardiorespiratory function has always been recognised as death, some view the de...

Research Nirmatrelvir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records Yan Xie, Benjamin Bowe, Ziyad Al-Aly BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-073312 (Published 11 April 2023)Cite this as: BMJ 2023;381:e073312 Abstract Objective To estimate the effectiveness of nirmatrelvir, compared with no treatment, in reducing admission to hospital or death at 30...

Research Beverage consumption and mortality among adults with type 2 diabetes: prospective cohort study Chang Liu, Giovanni E Ferreira, Christina Abdel Shaheed, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-073406 (Published 19 April 2023)Cite this as: BMJ 2023;381:e073406 Abstract Objective To investigate the intake of specific types of beverages in relation to mortality and cardiovascular disease (CVD) outcomes among adults with type 2 di...

Medical News & Perspectives  March 20, 2023 Highlights From the American College of Cardiology’s 2023 Scientific Session: the Ketogenic Diet and Cardiac Events, a Wearable Sensor to Predict Troponin Levels, Bempedoic Acid for Statin Intolerance, and More Melissa Suran JAMA. Published online March 20, 2023. doi:10.1001/jama.2023.0156 The annual conference of the American College of Cardiology and World Congress of Cardiology, held in early...

Drones Delivering Automated External Defibrillators Out-of-Hospital Cardiac Arrest (OHCA) is a dangerous condition with high mortality and poor health outcomes. According to the International Liaison Committee for Resuscitation (ILCOR), the global incidence of OHCA treated by emergency medical services (EMS) is 30.0-97.1 per 100,000 population, with discharge/30-day survival rates of 3.1-20.4% and good neurological outcomes of 2.8±18.2%. OHCA incidence in Europe is...

ORIGINAL ARTICLE Effect of Donor Sex on Recipient Mortality in Transfusion Michaël Chassé, Dean A. Fergusson, Alan Tinmouth, et al N Engl J Med 2023; 388:1386-1395DOI: 10.1056/NEJMoa2211523 Abstract BACKGROUND Conflicting observational evidence exists regarding the association between the sex of red-cell donors and mortality among transfusion recipients. Evidence to inform transfusion practice and policy is limited. METHODS In this multicenter, dou...