ARTICLES|ONLINE FIRST Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial Bruno François, Simon Lambden, Tom Fivez, et al. Lancet Respir Med Published:May 31, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00158-3 Summary Background Activation of the triggering receptor expressed on...

ARTICLES| VOLUME 11, ISSUE 6, P520-529, JUNE 2023 Outcome predictors and patient progress following delivery in pregnant and postpartum patients with severe COVID-19 pneumonitis in intensive care units in Israel (OB-COVICU): a nationwide cohort study Elena Fatnic, Nikole Lee Blanco, Roman Cobiletchi, et al. Lancet Respir Med 2023; 11: 520-529 DOI:https://doi.org/10.1016/S2213-2600(22)00491-X Summary Background A key unresolved controver...

ARTICLES| VOLUME 4, ISSUE 6, E431-E441, JUNE 2023 Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, et al. Lancet Microbe 2023; 4: E431-E441 DOI:https://doi.org/10.1016/S2666-5247(23)00041-1 Summary Background The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear...

Editorials Understanding the burden of post-covid-19 condition Qiao Wu BMJ 2023; 381 doi: https://doi.org/10.1136/bmj.p932 (Published 31 May 2023)Cite this as: BMJ 2023;381:p932 A complex picture is emerging, along with urgent priorities for future research Covid-19 cases and deaths have decreased globally,1 yet, the long term consequences of infection, including post-covid-19 condition (often known as long covid), are still being managed. Most people ...

Editorial  May 21, 2023 Conversations on Goals of Care With Hospitalized, Seriously Ill Patients Douglas B. White, Sarah K. Andersen JAMA. Published online May 21, 2023. doi:10.1001/jama.2023.8970 Goals-of-care conversations between clinicians and patients with serious illness have been shown to improve measures of patient and family well-being, while also decreasing health care costs and high-intensity treatments at the end of life.1,2 ...

ARTICLES| VOLUME 4, ISSUE 6, E418-E430, JUNE 2023 Omicron BA.1-specific T-cell responses in adults vaccinated with CoronaVac or BNT162b2 in Hong Kong: an observational cohort study Chris Ka Pun Mok, Chunke Chen, Shilin Zhao, et al. Lancet Microbe 2023; 4: E418-E430 DOI:https://doi.org/10.1016/S2666-5247(23)00006-X Summary Background The primary aim of using vaccines in public health responses to SARS-CoV-2 variants of concern is to redu...

EDITORIAL Video Laryngoscopy for Intubation — Time for a New Paradigm? Yonathan Freund, Ben Bloom N Engl J Med June 16, 2023DOI: 10.1056/NEJMe2305596 Endotracheal intubation — a potentially lifesaving procedure that is used for the care of many critically ill patients — demands precision, speed, and skill. It involves the placement of a tube into the trachea to protect the airways while ensuring adequate oxygenation and ventilation for patients who are in resp...

ARTICLES| VOLUME 4, ISSUE 6, E409-E417, JUNE 2023 SARS-CoV-2 incubation period across variants of concern, individual factors, and circumstances of infection in France: a case series analysis from the ComCor study Simon Galmiche, Thomas Cortier, Tiffany Charmet, et al. Lancet Microbe 2023; 6: E409-E417 DOI:https://doi.org/10.1016/S2666-5247(23)00005-8 Summary Background The incubation period of SARS-CoV-2 has been estimated for the know...

EDITORIAL A New Step in Postexposure Prophylaxis for Leprosy David M. Scollard N Engl J Med 2023; 388:1904-1905DOI: 10.1056/NEJMe2302667 Infection with Mycobacterium leprae is curable with a combination of dapsone, rifampin, and clofazimine (multidrug therapy), as recommended by the World Health Organization (WHO) in 1982. The use of this multidrug regimen led to an initial rapid decline in the global prevalence of M. leprae infection, a re...

ARTICLES| VOLUME 4, ISSUE 6, E397-E408, JUNE 2023 Risk factors and vectors for SARS-CoV-2 household transmission: a prospective, longitudinal cohort study Nieves Derqui, Aleksandra Koycheva, Jie Zhou, et al Lancet Microbe 2023; 4: E397-E408 DOI:https://doi.org/10.1016/S2666-5247(23)00069-1 Summary Background Despite circumstantial evidence for aerosol and fomite spread of SARS-CoV-2, empirical data linking either pathway with transmissi...