EDITORIAL Routine Early ECLS in Infarct-Related Cardiogenic Shock? Jane A. Leopold, Darren B. Taichman N Engl J Med August 26, 2023DOI: 10.1056/NEJMe2309395 The 30-day mortality among patients with an acute myocardial infarction complicated by cardiogenic shock who undergo coronary-artery revascularization procedures approaches 50% in contemporary clinical trials and registries.1 In patients with persistent hemodynamic compromise and organ hypoperfusion d...

ARTICLES| VOLUME 4, ISSUE 8, E591-E600, AUGUST 2023Download Full Issue Evaluating the relationship between community water and sanitation access and the global burden of antibiotic resistance: an ecological study Erica R Fuhrmeister, Abigail P Harvey, Maya L Nadimpalli, et al Lancet Microbe 2023; 4: E591-E600 Published:June 30, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00137-4 Summary Background Antibiotic resistance is a leading c...

ORIGINAL ARTICLE Health Consequences of Thymus Removal in Adults Kameron A. Kooshesh, Brody H. Foy, David B. Sykes, et al N Engl J Med 2023; 389:406-417DOI: 10.1056/NEJMoa2302892 Abstract BACKGROUND The function of the thymus in human adults is unclear, and routine removal of the thymus is performed in a variety of surgical procedures. We hypothesized that the adult thymus is needed to sustain immune competence and overall health. METHODS We evalua...

Editorial  July 25, 2023 Acute Bacterial Sinusitis: Limitations of Test-Based Treatment Tania M. Caballero, Brandon S. A. Altillo, Aaron M. Milstone JAMA. 2023;330(4):326-327. doi:10.1001/jama.2023.11365 Millions of cases of upper respiratory tract infections (URTIs) occur in the US each year and are more common among children than adults. Most URTIs are viral in origin and self-limited, but up to 50% of all patient encounters for viral URTI ...

ORIGINAL ARTICLE Extracorporeal Life Support in Infarct-Related Cardiogenic Shock Holger Thiele, Uwe Zeymer, Ibrahim Akin, et al N Engl J Med August 26, 2023DOI: 10.1056/NEJMoa2307227 Abstract BACKGROUND Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack of evidence regarding its effect on mortality. METHODS In this multicenter trial, patients with acute myocardial infarction...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Kidney Replacement Therapy in the Intensive Care Unit Kidney Replacement Therapy is a commonly used therapeutic strategy in the intensive care unit for patients who develop Acute Kidney Injury or who already have a diagnosis of chronic kidney disease. ICU staff should know when to use it and which type is most suitable for the circumstances. Epidemiology and Outcomes of AKI Acute kidney injury (AKI)...

ARTICLES|ONLINE FIRST Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study Alexander M Aiken, Andrea M Rehman, Marlieke E A de Kraker, et al Lancet Infect Dis Published:July 13, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00233-5 Summary Background Bacteria of the order Enterobacterales are common pathogens causing bl...

Editorials Private equity takeovers are harming patients Merrill Goozner BMJ 2023; 382 doi: https://doi.org/10.1136/bmj.p1396 (Published 19 July 2023)Cite this as: BMJ 2023;382:p1396 Evidence review suggests that costs rise and quality falls at acquired healthcare providers Private equity investment in healthcare provider institutions reached record highs in recent years in both the US and Europe, with US acquisitions accounting for three quarters of the co...

ARTICLES| VOLUME 23, ISSUE 8, P945-955, AUGUST 2023Download Full Issue Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial Nathan J Brendish, Kate R Beard, Ahalya K Malachira, et al Lancet Infect Dis 2023; 8: 945-955 Published:April 25, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00066-X ...

Diagnostic Accuracy of Monocyte Distribution Width, Procalcitonin and C‐Reactive Protein Sepsis is characterised by a dysregulated host response to infection resulting in organ dysfunction. It poses a significant global health problem, with a high mortality risk and millions of patients affected annually. Epidemiological studies have shown that nearly 20% of septic patients require mechanical ventilation, leading to significant healthcare costs. Despite clinical gu...