Antioxidant, Anti-inflammatory Therapy in Sepsis Sepsis is associated with long-term cognitive impairment and poor psychological and functional outcomes. Potential mechanisms for this include intracerebral oxidative stress and inflammation. However, there is limited knowledge about the effects of early antioxidant and anti-inflammatory therapy on cognitive, psychological, and functional outcomes in sepsis survivors. The Vitamin C, Thiamine, and Steroids in Sepsi...

ORIGINAL ARTICLE Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia Floor L.F. van Baarle, Emma K. van de Weerdt, Walter J.F.M. van der Velden, et al N Engl J Med 2023; 388:1956-1965DOI: 10.1056/NEJMoa2214322 Abstract BACKGROUND Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine...

ARTICLES|ONLINE FIRST Measuring the global response to antimicrobial resistance, 2020–21: a systematic governance analysis of 114 countries Jay Patel, Anne Harant, Genevie Fernandes, et al Lancet Infect Dis Published:January 16, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00796-4 Summary Background Understanding strategic commitments and policy responses to overcome antimicrobial resistance at the national, regional, and global levels is required t...

COMMENT|ONLINE FIRST Too many antibiotics for patients with COVID-19 despite low bacterial infections Daniele Roberto Giacobbe, Matteo Bassetti Lancet Infect Dis Published:January 27, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00866-0 Although low rates of bacterial infections have frequently been reported in patients hospitalised with COVID-19, excessive use of antibiotics has also been described in this population since the beginning of the COVID-19 p...

European Guidelines: Management of Bleeding, Coagulopathy Following Trauma According to the Global Burden of Diseases, Injuries, and Risk Factors Study, trauma accounted for 8% of total deaths annually. Among adolescents aged 10-24 years, road injuries, self-harm, and interpersonal violence are the top causes of disability-adjusted life-years, and road injuries are ranked first in the 25-49 year age group. Post-traumatic bleeding and associated traumatic coagulopat...

ARTICLES|ONLINE FIRST Incidence of infection with multidrug-resistant Gram-negative bacteria and vancomycin-resistant enterococci in carriers: a systematic review and meta-regression analysis Roel P J Willems, Karin van Dijk, Maria J G T Vehreschild, et al Lancet Infect Dis Published:January 30, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00811-8 Summary Background Carriers of multidrug-resistant bacteria are at risk of infections with these bacter...

ARTICLES|ONLINE FIRST Efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalised with COVID-19 (COVASP): a pragmatic, cluster-randomised, non-inferiority trial Justin Z Chen, Holly L Hoang, Maryna Yaskina, et al Lancet Infect Dis Published:January 27, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00832-5 Summary Background The COVID-19 pandemic has been associated with increased antimicrobial use despite ...

ARTICLES|ONLINE FIRST Guideline adherence and survival of patients with candidaemia in Europe: results from the ECMM Candida III multinational European observational cohort study Martin Hoenigl, Jon Salmanton-García, Matthias Egger, et al Lancet Infect Dis Published:February 15, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00872-6 Summary Background The European Confederation of Medical Mycology (ECMM) collected data on epidemiology, risk ...

Prehospital Physician Presence During Paediatric OHCA A study was conducted to investigate whether the presence of prehospital physicians affected the neurological outcomes of paediatric patients who experienced an out-of-hospital cardiac arrest (OHCA). The study included paediatric patients who were 17 years old or younger and were registered in a database between June 2014 and December 2019.  The researchers used logistic regression models and stabil...

ARTICLES|ONLINE FIRST Prevention of non-ventilator-associated hospital-acquired pneumonia in Switzerland: a type 2 hybrid effectiveness–implementation trial Aline Wolfensberger, Lauren Clack, Stefanie von Felten, et al Lancet Infect Dis Published:March 06, 2023 DOI:https://doi.org/10.1016/S1473-3099(22)00812-X Summary Background Non-ventilator-associated hospital-acquired pneumonia (nvHAP) is a frequent, but under-researched infection. We aimed to sim...