Original Investigation  June 6, 2023 The Volume and Cost of Quality Metric Reporting Anirudh Saraswathula, Samantha J. Merck, Ge Bai, et al JAMA. 2023;329(21):1840-1847. doi:10.1001/jama.2023.7271 Key Points Question  What is the annual cost to an acute care hospital of measuring and reporting quality metric data, excluding resources spent on quality improvement interventions? Findings  Preparing and reporting data f...

ORIGINAL ARTICLE Transplantation Outcomes with Donor Hearts after Circulatory Death Jacob N. Schroder, Chetan B. Patel, Adam D. DeVore, et al N Engl J Med 2023; 388:2121-2131DOI: 10.1056/NEJMoa2212438 Abstract BACKGROUND Data showing the efficacy and safety of the transplantation of hearts obtained from donors after circulatory death as compared with hearts obtained from donors after brain death are limited. METHODS We conducted a randomized, nonin...

Original Investigation  June 2, 2023 Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial Deborah Schrag, Hajime Uno, Rachel Rosovsky, et al JAMA. Published online June 2, 2023. doi:10.1001/jama.2023.7843 Key Points Question  Among patients with cancer and a venous thromboembolism (VTE) event, are direct oral anticoagulants noninferior to low-molecular-w...

Cardiovascular Subphenotypes in ARDS Acute respiratory distress syndrome (ARDS) is a frequently observed condition in mechanically ventilated patients in ICUs and is associated with a high mortality rate. The presence of shock in ARDS indicates poor prognosis, with echocardiography studies suggesting that right ventricular dysfunction (RVD) plays a significant role in the cardiovascular dysfunction observed in this condition. However, the definition of RVD in the c...

Practice Practice Pointer Towards net zero: critical care Heather Baid, Eleanor Damm, Louise Trent, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2021-069044 (Published 01 June 2023)Cite this as: BMJ 2023;381:e069044 What you need to know Critical care is resource intensive, using large amounts of energy, pharmaceuticals, and single-use consumables, all of which potentially have a harmful impact on the environment We can view environmental s...

ARTICLES|ONLINE FIRST Risk and accuracy of outpatient-identified hypoxaemia for death among suspected child pneumonia cases in rural Bangladesh: a multifacility prospective cohort study Eric D McCollum, Salahuddin Ahmed, Arunangshu D Roy, et al. Lancet Respir Med Open Access Published:April 07, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00098-X Summary Background Hypoxaemic pneumonia mortality risk in low-income and middle-income countries is high...

ICU Management & Practice, Volume 23 - Issue 1, 2023 The Footprints of a Gigantic Hound – Biomarkers in Intensive Care Biomarkers hint at the pathophysiology behind a clinical entity, leading to better treatments. Access to biomarker testing may improve drug discovery in clinical trials, responses at the bedside and personalised patient management. The human body is a construct of chemical fires – each with a characteristic smoke signal. The smoke signal...

ARTICLES|ONLINE FIRST Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with cardiac arrest: a comparative meta-analysis and trial sequential analysis Christopher Jer Wei Low, Kollengode Ramanathan, Ryan Ruiyang Ling, et al. Lancet Respir Med Published:May 22, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00137-6 Summary Background Although outcomes of patients after cardiac arrest remain poor, s...

ARTICLES|ONLINE FIRST Prospective evaluation of the efficacy, safety, and optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock (ASTONISH): a double-blind, randomised, controlled, phase 2b trial Bruno François, Simon Lambden, Tom Fivez, et al. Lancet Respir Med Published:May 31, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00158-3 Summary Background Activation of the triggering receptor expressed on...

ARTICLES| VOLUME 11, ISSUE 6, P520-529, JUNE 2023 Outcome predictors and patient progress following delivery in pregnant and postpartum patients with severe COVID-19 pneumonitis in intensive care units in Israel (OB-COVICU): a nationwide cohort study Elena Fatnic, Nikole Lee Blanco, Roman Cobiletchi, et al. Lancet Respir Med 2023; 11: 520-529 DOI:https://doi.org/10.1016/S2213-2600(22)00491-X Summary Background A key unresolved controver...