ONLINE FIRST (FREE ACCESS) OPEN ACCESS ~ OriginalAcute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial Xiang Wu on behalf of the ACES Participants Interferon gamma-1b for the prevention of hospital-acquired pneumonia in critically ill patients: a phase 2, placebo-controlled randomized clinical trialRoquilly A. et al. Association between prehospital end-tidal carbon dioxide levels and mortality in patients with ...

Research Letter  May 2, 2023 Availability, Cost, and Consumer Ratings of Popular Nonvalidated vs Validated Blood Pressure–Measuring Devices Sold Online in 10 Countries Dean S. Picone, Niamh Chapman, Martin G. Schultz, et al JAMA. 2023;329(17):1514-1516. doi:10.1001/jama.2023.2661 For clinic and home blood pressure (BP) monitoring, hypertension guidelines recommend using automated upper arm cuff BP-measuring devices that have undergone adequat...

Research Molnupiravir and risk of post-acute sequelae of covid-19: cohort study Yan Xie, Taeyoung Choi, Ziyad Al-Aly BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-074572 (Published 25 April 2023)Cite this as: BMJ 2023;381:e074572 Abstract Objective To examine whether treatment with the antiviral agent molnupiravir during the first five days of SARS-CoV-2 infection is associated with reduced risk of post-acute adverse health outcomes. Design&nb...

Family-Centred Care at End of Life in the ICU Recent research on end-of-life (EOL) care in the ICU has focused on the importance of communication between ICU clinicians and patients' families. This research has highlighted the impact of such communication on family symptoms in the months following a patient's death. During the COVID-19 pandemic, restricted visiting policies in ICUs have undermined the quality of communication between clinicians and families, whi...

Research Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial Peter S Blair, Grace Young, Clare Clement, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-072488 (Published 26 April 2023)Cite this as: BMJ 2023;381:e072488 Abstract Objective To assess whether an easy-to-use multifaceted interv...

Invited Commentary  April 28, 2023 How Chatbots and Large Language Model Artificial Intelligence Systems Will Reshape Modern Medicine: Fountain of Creativity or Pandora’s Box? Ron Li, Andre Kumar, Jonathan H. Chen JAMA Intern Med. Published online April 28, 2023. doi:10.1001/jamainternmed.2023.1835 In an era of clinicians being burnt out by electronic medical records and documentation burdens, we might all dream of having a personal scribe to...

Original Investigation  April 28, 2023 Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum John W. Ayers, Adam Poliak, Mark Dredze, et al JAMA Intern Med. Published online April 28, 2023. doi:10.1001/jamainternmed.2023.1838 Key Points Question  Can an artificial intelligence chatbot assistant, provide responses to patient questions that are of comparable qua...

ICU Management & Practice, Volume 22 - Issue 5, 2022 Guiding Clinical Care Using Pancreatic Stone Protein The role of point-of-care testing in the early identification and management of sepsis, the need for better markers to identify sepsis, an overview of the Pancreatic Stone Protein (PSP) and clinical evidence highlighting its effectiveness as a biomarker. Pancreatic Stone Protein Infections are a leading cause of morbidity and mortality among criti...

ARTICLES|ONLINE FIRST Effectiveness of handwashing with soap for preventing acute respiratory infections in low-income and middle-income countries: a systematic review and meta-analysis Ian Ross, Sarah Bick, Philip Ayieko, et al Lancet Published:April 27, 2023 DOI:https://doi.org/10.1016/S0140-6736(23)00021-1 Summary Background Acute respiratory infection (ARI) is a leading cause of morbidity and mortality globally, with 83% of ARI mortality occurring...

ARTICLES|ONLINE FIRST Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study Jesús F Bermejo-Martin, Nadia García-Mateo, Anna Motos, et al Lancet Microbe Published:April 25, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00041-1 Summary Background The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations be...