Research Letter  June 15, 2023 Accuracy of a Generative Artificial Intelligence Model in a Complex Diagnostic Challenge Zahir Kanjee, Byron Crowe, Adam Rodman JAMA. Published online June 15, 2023. doi:10.1001/jama.2023.8288 Recent advances in artificial intelligence (AI) have led to generative models capable of accurate and detailed text-based responses to written prompts (“chats”). These models score highly on standardized medical examinatio...

Original Investigation  June 20, 2023 Recent Vitamin K Antagonist Use and Intracranial Hemorrhage After Endovascular Thrombectomy for Acute Ischemic Stroke Brian Mac Grory, DaJuanicia N. Holmes, Roland A. Matsouaka, et al JAMA. 2023;329(23):2038-2049. doi:10.1001/jama.2023.8073 Key Points Question  In patients with acute ischemic stroke due to large vessel occlusion selected to receive endovascular thrombectomy (EVT), does recent...

Research Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study Marc Raynaud, Solaf Al-Awadhi, Ivana Juric, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-073654 (Published 31 May 2023)Cite this as: BMJ 2023;381:e073654 Abstract Objective To compare the performance of a newly developed race-free kidney recipient specific glomerular filtration rate (GFR) equation with the thre...

Role of Nurse-to-Nurse Familiarity on Mortality Nursing teams play an important role in providing safe and adequate care to critically ill patients in the ICU. The patient-to-nurse ratio significantly impacts patient outcomes, and teamwork is also crucial. A recent study emphasises the need for effective communication, collaboration, and a shared sense of responsibility among the nursing team to ensure optimal patient care. The authors suggest that investing in ...

ORIGINAL ARTICLE Tirofiban for Stroke without Large or Medium-Sized Vessel Occlusion Wenjie Zi, Jiaxing Song, Weilin Kong, et al N Engl J Med 2023; 388:2025-2036DOI: 10.1056/NEJMoa2214299 Abstract BACKGROUND The effects of the glycoprotein IIb/IIIa receptor inhibitor tirofiban in patients with acute ischemic stroke but who have no evidence of complete occlusion of large or medium-sized vessels have not been extensively studied. 背景 糖蛋白Ⅱb/Ⅲa受体...

Critical Care in Conflict Zones Conflict zones often involve gunfights, bomb blasts, and mass casualty incidents. However, patients in conflict zones may also present with everyday medical problems unrelated to trauma. Despite the challenges of working in a conflict zone, healthcare professionals strive to provide care for all patients, including those with chronic medical conditions. In 2021, MSF, a medical humanitarian organisation, provided medical care to 7,...

EDITORIAL Reinforcing the Checkpoint in Rheumatoid Arthritis Ellen M. Gravallese, Ranjeny Thomas N Engl J Med 2023; 388:1905-1907DOI: 10.1056/NEJMe2300734 Programmed cell death protein 1 (PD-1) is a critical inhibitory receptor in lymphocyte activation, acting as an immune checkpoint to prevent the continued activation of T cells after an immune response and to maintain peripheral immune tolerance. PD-1 is a marker of antigen-experienced T cells. With sustaine...

Research Analysis of peer reviewers’ response to invitations by gender and geographical region: cohort study of manuscripts reviewed at 21 biomedical journals before and during covid-19 pandemic Khaoula Ben Messaoud, Sara Schroter, Mark Richards, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-075719 (Published 13 June 2023)Cite this as: BMJ 2023;381:e075719 Abstract Objectives To describe gender and geographical inequalities in invitations t...

Two Shocks Better Than One? In a recent investigation, the researchers aimed to answer whether alternative defibrillation strategies, including vector-change (VC) defibrillation and double sequential external defibrillation (DSED), improve survival to hospital discharge in patients experiencing out-of-hospital cardiac arrest with refractory ventricular fibrillation. The authors chose a cluster randomised controlled trial as the study design to investigate the ef...

JAMA Clinical Guidelines Synopsis  June 17, 2023 Caring for Patients With Acute Respiratory Distress Syndrome: Summary of the 2023 ESICM Practice Guidelines Derek C. Angus, Christopher W. Seymour, Kirsten Bibbins-Domingo JAMA. Published online June 17, 2023. doi:10.1001/jama.2023.6812 Guideline title ESICM Guidelines on Acute Respiratory Distress Syndrome: Definition, Phenotyping and Respiratory Support Strategies Release date Ju...