ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalIntensivist physician-to-patient ratios and mortality in the intensive care unitKahn J.M.. et al. OPEN ACCESS ~ What's New in Intensive CareWhat’s new in therapeutic drug monitoring of antimicrobials?Sjövall F., Lanckohr C. and Bracht H. Ventilator associated tracheobronchitis and pneumonia: one infection with two facesMartin-Loeches I., Povoa P. and Nseir S. To mobilise or not to mobilise: is that the righ...

Original Investigation  Caring for the Critically Ill Patient May 21, 2023 Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial J. Randall Curtis, Robert Y. Lee, Lyndia C. Brumback, et al JAMA. Published online May 21, 2023. doi:10.1001/jama.2023.8812 Key Points Question  Can a patient-specific, clinician-facing communication-priming intervention ...

#ISICEM23: Effects of Therapeutic-Dose Heparin in Hospitalised Patients With COVID-19 At the #ISICEM23 this week in Brussels, the benefits and harms of therapeutic-dose heparin varied by hospitalised COVID-19 patient characteristics were discussed, and the importance of considering the heterogeneity of treatment effect (HTE) in the design and analysis of randomised clinical trials was highlighted. To date, RCTs that have tested therapeutic-dose heparin in COVID-...

Medical News & Perspectives  May 3, 2023 Artificial Intelligence, Emerging Threats, and Diagnostic Advances—Highlights From ECCMID, Europe’s Largest Infectious Disease Conference Preeti Malani JAMA. Published online May 3, 2023. doi:10.1001/jama.2023.6066 For more than 14 000 infectious diseases physicians, clinical microbiologists, and public health professionals, gathering in Copenhagen, Denmark, in April was a special occasion. The Eur...

Original Investigation  May 21, 2023 Airway-Occluding Mucus Plugs and Mortality in Patients With Chronic Obstructive Pulmonary Disease Alejandro A. Diaz, José L. Orejas, Scott Grumley, et al JAMA. Published online May 21, 2023. doi:10.1001/jama.2023.2065 Key Points Question  Are mucus plugs that occlude airways identified on computed tomography scans in patients with chronic obstructive pulmonary disease (COPD) associated with in...

ICU Management & Practice, Volume 23 - Issue 1, 2023 Biomarkers in Sepsis This article describes the application of existing and emerging biomarkers in the diagnosis and management of sepsis and pneumonia. Introduction: The Need for Biomarkers in Sepsis Sepsis is defined as a dysregulated host response to infection that results in life threatening organ dysfunction. It carries an estimated 30-day mortality rate of 24.4% and increases to ...

Research Women and non-white people among Lasker Award recipients from 1946 to 2022: cross sectional study Jeremy W Jacobs, Lorin A Bibb, Elizabeth S Allen, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2023-074968 (Published 17 May 2023)Cite this as: BMJ 2023;381:e074968 Abstract Objective To determine whether gender and racial inequities exist among Lasker Award recipients. Design Observational, cross sectional analysis. Setting&nbs...

ORIGINAL ARTICLE Single-Dose Rifapentine in Household Contacts of Patients with Leprosy Le Wang, Hongsheng Wang, Liangbin Yan, et al N Engl J Med 2023; 388:1843-1852DOI: 10.1056/NEJMoa2205487 Abstract BACKGROUND Previous studies have suggested that a single dose of rifampin has protective effects against leprosy in close contacts of patients with the disease. Rifapentine was shown to have greater bactericidal activity against Mycobacterium leprae than ri...

Editorial  May 9, 2023 The Future of Clinical Trials in Idiopathic Pulmonary Fibrosis Anna J. Podolanczuk, Luca Richeldi, Fernando J. Martinez JAMA. 2023;329(18):1554-1555. doi:10.1001/jama.2022.23955 Idiopathic pulmonary fibrosis (IPF) currently affects about 100 000 individuals in the US, and millions globally. Patients living with IPF experience disabling symptoms and progressive loss of lung function.1 The 2 treatments approved by th...

ORIGINAL ARTICLE Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage Ioannis Gallos, Adam Devall, James Martin, et al N Engl J Med May 9, 2023DOI: 10.1056/NEJMoa2303966 Abstract BACKGROUND Delays in the detection or treatment of postpartum hemorrhage can result in complications or death. A blood-collection drape can help provide objective, accurate, and early diagnosis of postpartum hemorrhage, and delayed or inconsistent use of ef...