ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS What's New in Intensive Care Ventilator-induced lung injury: between tidal recruitment, overdistension, and the baby lung paradigmPlens, G.M., Costa, E.L.V. & Amato, M.B.P. How to interpret abnormal standard coagulation tests at the bedside in critically ill patients?Helms, J., Liu, L. & Russell, L. Understanding the Disease Immune responses and immunomodulation in sepsis: a call for ident...

CONFERENCE REPORTS AND EXPERT PANEL Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) Leone, M., Myatra, S.N., Dugar, S. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08344-2 Abstract Objective A definition of refractory septic shock is necessary to guide diagnosis, management, prognostic...

EDITORIAL TRACTION for Greater Surgical Use of Tranexamic Acid Michael F. Murphy, Ian Roberts N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMe2603105 Every year, many millions of surgical patients worldwide are unnecessarily exposed to a higher-than-necessary risk of blood transfusion because they do not receive a single dose of tranexamic acid just before the surgery. This failing is due not to a lack of high-quality scientific eviden...

Original Investigation  Caring for the Critically Ill Patient Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults: A Randomized Clinical Trial Regis Goulart Rosa, Rafael Barberena Moraes, Geraldine Trott, et al JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10617 Key Points Question  Among adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation, does a...

JAMA Clinical Guidelines Synopsis  Caring for Pediatric Patients With Sepsis Tracy A. Lieu, Jason T. Alexander, Christopher W. Seymour JAMA Published Online: March 26, 2026 doi: 10.1001/jama.2026.3800 Guideline title Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026 Release date March 23, 2026 Prior version 2020 Developer and funding source Society of Critical Care ...

ORIGINAL ARTICLE Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery Brett L. Houston, Daniel I. McIsaac, Rodney H. Breau, et al N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2515820 Abstract BACKGROUND Whether a hospital policy of tranexamic acid administration for patients undergoing major noncardiac surgery safely reduces the need for red-cell transfusion is uncertain. METHODS We conducted a multicen...

JAMA Clinical Guidelines Synopsis  Caring for Adult Patients With Sepsis Christopher W. Seymour, Kirsten Bibbins-Domingo, Jason T. Alexander JAMA Published Online: March 26, 2026 doi: 10.1001/jama.2026.3793 Guideline title Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026 Release date March 23, 2026 Developer European Society of Intensive Care Medicine (ESICM) and Society of Critical Care...

Invasive & Non-Invasive Monitoring of Inspiratory Effort & Drive in Assisted Mechanical Ventilation In ICU Wed, 21 Jan 2026 A clinical review examined the invasive and non-invasive monitoring of inspiratory effort and respiratory drive in patients undergoing assisted mechanical ventilation (AMV). Following the acute phase of respiratory failure, AMV is commonly used to support spontaneous breathing, improve gas exchange, and reduce sedation req...

Editorial  Can Transesophageal Echocardiography–Guided CPR Improve Out-of-Hospital Cardiac Arrest Outcomes? Teva D. Brender, Tracy Y. Wang, Sharon K. Inouye, et al JAMA Intern Med Published Online: March 23, 2026 doi: 10.1001/jamainternmed.2026.0115 Worldwide, an estimated 3.8 million persons experience an out-of-hospital cardiac arrest (OHCA) annually.1 In the United States, only 8.2% of individuals with an OHCA survive with a favorable neurological o...

ORIGINAL ARTICLE Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2513814 Abstract BACKGROUND In patients who are unresponsive after resuscitation from cardiac arrest, limiting oxygen exposure to that necessary to achieve acceptable oxygenation may increase the likelihood of...