EDITORIAL A New Step in Postexposure Prophylaxis for Leprosy David M. Scollard N Engl J Med 2023; 388:1904-1905DOI: 10.1056/NEJMe2302667 Infection with Mycobacterium leprae is curable with a combination of dapsone, rifampin, and clofazimine (multidrug therapy), as recommended by the World Health Organization (WHO) in 1982. The use of this multidrug regimen led to an initial rapid decline in the global prevalence of M. leprae infection, a re...

ARTICLES| VOLUME 4, ISSUE 6, E397-E408, JUNE 2023 Risk factors and vectors for SARS-CoV-2 household transmission: a prospective, longitudinal cohort study Nieves Derqui, Aleksandra Koycheva, Jie Zhou, et al Lancet Microbe 2023; 4: E397-E408 DOI:https://doi.org/10.1016/S2666-5247(23)00069-1 Summary Background Despite circumstantial evidence for aerosol and fomite spread of SARS-CoV-2, empirical data linking either pathway with transmissi...

Research Recovery and symptom trajectories up to two years after SARS-CoV-2 infection: population based, longitudinal cohort study Tala Ballouz, Dominik Menges, Alexia Anagnostopoulos, et al BMJ 2023; 381 doi: https://doi.org/10.1136/bmj-2022-074425 (Published 31 May 2023)Cite this as: BMJ 2023;381:e074425 Abstract Objective To evaluate longer term symptoms and health outcomes associated with post-covid-19 condition within a cohort of individuals with ...

Editorial  June 20, 2023 Revisiting the Analogy Between Clinical Trials and Diagnostic Tests by Interpreting a Negative Trial as a Negative Test for Efficacy Roger J. Lewis, Kert Viele JAMA. 2023;329(23):2023-2025. doi:10.1001/jama.2023.8972 As noted in JAMA more than 30 years ago,1 randomized clinical trials are like diagnostic tests in several ways. Clinical trials are designed to detect hypothesized treatment effects in the ...

Original Investigation  June 20, 2023 Evidence of Lack of Treatment Efficacy Derived From Statistically Nonsignificant Results of Randomized Clinical Trials Thomas Perneger, Angèle Gayet-Ageron JAMA. 2023;329(23):2050-2056. doi:10.1001/jama.2023.8549 Key Points Question  Can a statistically nonsignificant result of a randomized clinical trial provide conclusive evidence of lack of effect of the new treatment? Findings &nb...

Perspective Toward Comprehensive Care for Long Covid Janko Ž. Nikolich, Clifford J. Rosen N Engl J Med May 9, 2023DOI: 10.1056/NEJMp2304550 Three years into the Covid pandemic, SARS-CoV-2 is still with us. As the virus evolves, it continues to pose a health threat in terms of both acute infections (or reinfections) and postacute sequelae. In regard to the former, there is evidence that several pharmacologic interventions reduce the severity of infections, less...

Editorial  June 16, 2023 Do Prolonged Infusions of β-Lactam Antibiotics Improve Outcomes in Critically Ill Patients With Sepsis? Claire N. Shappell, Michael Klompas, Chanu Rhee JAMA. Published online June 16, 2023. doi:10.1001/jama.2023.6483 There has been a concerted effort over the past 2 decades to improve sepsis outcomes by enhancing recognition of sepsis and decreasing the time to administration of appropriate antibiotics.1 Sepsis m...

ORIGINAL ARTICLE Video versus Direct Laryngoscopy for Tracheal Intubation of Critically Ill Adults Matthew E. Prekker, Brian E. Driver, Stacy A. Trent, et al N Engl J Med June 16, 2023DOI: 10.1056/NEJMoa2301601 Abstract BACKGROUND Whether video laryngoscopy as compared with direct laryngoscopy increases the likelihood of successful tracheal intubation on the first attempt among critically ill adults is uncertain. METHODS In a multicenter, randomize...

Original Investigation  Caring for the Critically Ill Patient June 16, 2023 Continuous vs Intermittent Meropenem Administration in Critically Ill Patients With Sepsis: The MERCY Randomized Clinical Trial Giacomo Monti, Nikola Bradić, Matteo Marzaroli, et al JAMA. Published online June 16, 2023. doi:10.1001/jama.2023.10598 Key Points Question  Does continuous administration of meropenem reduce a composite of mortality and emerg...

Editorial  May 21, 2023 Conversations on Goals of Care With Hospitalized, Seriously Ill Patients Douglas B. White, Sarah K. Andersen JAMA. 2023;329(23):2021-2022. doi:10.1001/jama.2023.8970 Goals-of-care conversations between clinicians and patients with serious illness have been shown to improve measures of patient and family well-being, while also decreasing health care costs and high-intensity treatments at the end of life.1,2 Nonetheless, achi...