CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 163, ISSUE 1, P115-127, JANUARY 2023Download Full Issue A 30-Minute Spontaneous Breathing Trial Misses Many Children Who Go On to Fail a 120-Minute Spontaneous Breathing Trial Kelby E. Knox, Justin C. Hotz, Christopher J.L. Newth, et al Chest 2023; 163: 115-127 Published:August 26, 2022 DOI:https://doi.org/10.1016/j.chest.2022.08.2212 Background The optimal length of spontaneous breathing trials (SB...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 163, ISSUE 1, P64-76, JANUARY 2023Download Full Issue A Double-Blind Randomized Placebo-Controlled Phase 3 Trial of Tobramycin Inhalation Solution in Adults With Bronchiectasis With Pseudomonas aeruginosa Infection Wei-jie Guan, Jin-fu Xu, Hong Luo, et al Chest 2023; 163: 64-67 Published:July 18, 2022 DOI:https://doi.org/10.1016/j.chest.2022.07.007 Background Few large-scale studies hav...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Heparin-Induced Thrombocytopaenia Heparin-induced thrombocytopaenia (HIT) is an immune complication of heparin therapy. This review discusses the pathophysiology, incidence, clinical manifestations, diagnostic approach, and management of patients with HIT. Pathophysiology HIT is an immune complication of heparin therapy caused by IgG antibodies to complexes of platelet factor 4 (PF4) and heparin. Th...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 163, ISSUE 1, P128-138, JANUARY 2023Download Full Issue Temporal Trends and Variation in Bronchoscopy Use for Acute Respiratory Failure in the United States Max T. Wayne, Thomas S. Valley, Douglas A. Arenberg, et al Chest 2023; 163: 128-138 Published:August 22, 2022 DOI:https://doi.org/10.1016/j.chest.2022.08.2210 Background National data on bronchoscopy for the evaluation of acute respiratory failure are lacking,...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 163, ISSUE 2, P303-312, FEBRUARY 2023Download Full Issue High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial) Jayshil J. Patel, Rodney Willoughby, Jennifer Peterson, et al Chest 2023; 163: 303-312 Published:September 26, 2022 DOI:https://doi.org/10.1016...

CHEST INFECTIONS: ORIGINAL RESEARCH| VOLUME 163, ISSUE 3, P484-497, MARCH 2023Download Full Issue Effect of Corticosteroids on Mortality and Clinical Cure in Community-Acquired Pneumonia: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Control Trials Naveed Saleem, Adarsh Kulkarni, Timothy Arthur Chandos Snow, et al Chest 2023; 163: 484-497 Published:September 07, 2022 DOI:https://doi.org/10.1016/j.chest.2022.08.2229 Background Comm...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Which Vasopressors and Inotropes to Use in the Intensive Care Unit Vasopressors and inotropes are frequently used in intensive care units. With a special focus on recent studies, this article summarises the key messages in the management of patients requiring inotropes and vasopressors. Introduction Cardiac output (CO) is a key determinant of oxygen delivery. Low cardiac output syndrome (LCOS) cause...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 163, ISSUE 5, P1109-1119, MAY 2023Download Full Issue Comparative Effectiveness of Amiodarone and Lidocaine for the Treatment of In-Hospital Cardiac Arrest Deborah Wagner, S.L. Kronick, H. Nawer, et al Chest 2023; 153: 1109-1119 Published:November 01, 2022 DOI:https://doi.org/10.1016/j.chest.2022.10.024 Background American Heart Association Advanced Cardiac Life Support (ACLS) guidelines support the...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 163, ISSUE 3, P533-542, MARCH 2023Download Full Issue Prolonged Prone Position Ventilation Is Associated With Reduced Mortality in Intubated COVID-19 Patients Daniel Okin, Ching-Ying Huang, George A. Alba, et al Chest 2023; 163: 533-542 Published:November 04, 2022 DOI:https://doi.org/10.1016/j.chest.2022.10.034 Background Prone position ventilation (PPV) is resource-intensive, yet the optimal strate...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 163, ISSUE 4, P826-842, APRIL 2023Download Full Issue Days Spent at Home and Mortality After Critical Illness: A Cluster Analysis Using Nationwide Data Guillaume L. Martin, Alice Atramont, Marjorie Mazars, et al Chest 2023; 163: 826-842 Published:October 15, 2022 DOI:https://doi.org/10.1016/j.chest.2022.10.008 Background Beyond the question of short-term survival, days spent at home could be conside...