Original Investigation  May 10, 2023 Effects of Specialist Palliative Care for Patients Undergoing Major Abdominal Surgery for Cancer: A Randomized Clinical Trial Myrick C. Shinall Jr, Sara F. Martin, Mohana Karlekar, et al JAMA Surg. 2023;158(7):747-755. doi:10.1001/jamasurg.2023.1396 Key Points Question  Should patients undergoing nonpalliative surgery for cancer receive early specialist palliative care? Findings  In this ra...

#ISICEM23: Time to Get Strategic About ICU Burnout In an interesting session at #ISICEM23, Michelle Chew, Professor of Anesthesiology, Intensive care, and Acute Medicine Care at Linköping University Hospital, Sweden, talked about stress, anxiety, and burnout. Prof Chew discussed a study conducted by her group on perceived and physiological stress, anxiety, and burnout among ICU staff in an area with two million inhabitants. The study focused on staff in two majo...

Original Investigation  May 17, 2023 Association of Trauma With Long-Term Risk of Death and Immune-Mediated or Cancer Disease in Same-Sex Twins Trine O. Eskesen, Martin Sillesen, Jacob Krabbe Pedersen, et al JAMA Surg. 2023;158(7):738-745. doi:10.1001/jamasurg.2023.1560 Key Points Question  Is moderate to severe trauma associated with long-term increased risk of death or immune-mediated or cancer disease? Findings  In this nat...

Editorials Antenatal corticosteroids and longer term outcomes Jessica Kimpton, Audrienne Sammut, David J Cox BMJ 2023; 382 doi: https://doi.org/10.1136/bmj.p1722 (Published 02 August 2023)Cite this as: BMJ 2023;382:p1722 New evidence to consider before prescribing antenatal corticosteroids Antenatal corticosteroids are considered one of the most important interventions available to improve outcomes for preterm infants. They are recommended for women at risk...

Original Investigation  April 26, 2023 Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies Matthew R. Thau, Ted Liu, Neha A. Sathe, et al JAMA Surg. 2023;158(7):728-736. doi:10.1001/jamasurg.2023.0819 Key Points Question  Are trauma molecular endotypes associated with clinical outcomes and differential response to transfusion resuscitation strategies? Findings  In this s...

#ISICEM23: Findings from the PROCOAG Clinical Trial Findings from the PROCOAG randomised clinical trial were presented for the first time during the #ISICEM23 opening. The best way to manage transfusions in traumatic haemorrhage remains unclear. However, there are indications that using a 4-factor prothrombin complex concentrate (4F-PCC) could have a beneficial effect on blood product consumption. The PROCOAG study aimed to evaluate the efficacy and safety of...

Original Investigation  May 24, 2023 Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial Maple Goh, Clare Hollewand, Stephen McBride, et al JAMA Surg. 2023;158(7):718-726. doi:10.1001/jamasurg.2023.1201 Key Points Question  What effect does incision-site injection of microdosed antibiotics have on the rate of surgical site infection (SSI) before skin can...

Original Investigation  August 7, 2023 Effects of Cuff Size on the Accuracy of Blood Pressure Readings: The Cuff(SZ) Randomized Crossover Trial Junichi Ishigami, Jeanne Charleston, Edgar R. Miller III, et al JAMA Intern Med. Published online August 7, 2023. doi:10.1001/jamainternmed.2023.3264 Key Points Question  What is the effect of using a regular size blood pressure (BP) cuff regardless of an individual’s mid-upper arm circum...

Postextubation Noninvasive Respiratory Support in Patients with Acute Brain Injury: Not a Panacea, but Don’t Throw the Baby Out with the Bathwater! Romain Pirracchio and  Alejandro A. Rabinstein Am J Respir Crit Care Med 2023; 208: 225-226 Extubation failure is a common problem in patients with acute brain injury, with rates ranging from 15% to 25% across studies (1–3). Older age, longer duration of mechanical ventilation, and impaired airway protective reflexes ...

ICU Management & Practice, Volume 23 - Issue 1, 2023 Utility of Biomarkers in Obstetric Patients With Preeclampsia Preeclampsia is a complex syndrome whose complications bear an impact on perinatal morbidity and mortality. Angiogenic biomarkers may significantly impact both the decision to admit patients and risk stratification and may also help guide patient management and level of care. Preeclampsia is one of the main causes of maternal and foetal morb...