International Severity of Illness Scoring System In ICU Wed, 26 Nov 2025 Developing a globally applicable critical care severity score is an urgent priority for improving research, benchmarking, quality improvement, and public health response across diverse health systems. Severity scores have long been central to ICU practice, supporting benchmarking, risk adjustment, resource allocation, and disease characterisation. Yet, most existing scores were de...

Articles Survival effect of prehospital emergency anaesthesia with intubation in risk-stratified patients with major trauma: a causal modelling study Amy PK Nelson, Nick Dodds, Mohamad Zeina, et al Lancet Respir Med Available online 11 February 2026 https://doi.org/10.1016/S2213-2600(25)00370-4 Summary Background Trauma is among the top 10 most common causes of disability worldwide, accounting for more than 100 million disability-adjusted life-years (...

Original Investigation  Surgery Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery: A Systematic Review and Network Meta-Analysis Shahrzad Motaghi, Samer G. Karam, Francesca Mulazzani, et al JAMA Netw Open 2026;9;(2):e2560095. doi:10.1001/jamanetworkopen.2025.60095 Key Points Question  Which antibiotic prophylaxis regimens are associated with the lowest risk of surgical s...

Editorial  Evaluating Cryopreserved and Liquid-Stored Platelets for Bleeding During Cardiac Surgery Timothy A. Pritt JAMA Surg Published Online: February 18, 2026 doi: 10.1001/jamasurg.2025.6723 There is no substitute for blood during the treatment of hemorrhage. From the first reported successful transfusion of human blood to treat postpartum hemorrhage in 1825,1 to the early use of whole blood in combat casualty care during World War I,2 an...

Guideline-Driven LLM Boosts Sepsis Mortality Prediction  In Sepsis Tue, 2 Dec 2025 Sepsis remains a major cause of in-hospital mortality worldwide and places a substantial burden on intensive care units and healthcare systems. Despite regular updates to clinical guidance and advances in treatment, outcomes for many patients remain poor and early identification of those at highest risk continues to be challenging. Conventional risk scores and tradi...

Original Investigation  Statistics and Research Methods Design and Implementation of Observational Studies Emulating a Target Trial Yan Ren, Yulong Jia, Lingyan Liu, et al JAMA Netw Open 2026;9;(2):e2558262. doi:10.1001/jamanetworkopen.2025.58262 Key Points Question  In which clinical scenarios has target trial emulation (TTE) been applied, and how well do TTE studies adhere to key principles of target tr...

Invited Commentary  Anesthesiology Antibiotic Selection and Redosing to Prevent Surgical Site Infections—When Timing Is Not Enough Nicole A. Wilson JAMA Netw Open 2026;9;(2):e2559356. doi:10.1001/jamanetworkopen.2025.59356 Surgical site infections (SSIs) remain among the most common and costly complications following surgery, despite decades of quality improvement efforts. In this context, the multicenter cohort study by Bardia et al1 provides timely a...

Original Investigation  Critical Care Medicine Albumin Replacement Therapy in Septic Shock: A Randomized Clinical Trial Yasser Sakr, Axel Nierhaus, Ulrike Schumacher, et al JAMA Netw Open 2026;9;(2):e2559297. doi:10.1001/jamanetworkopen.2025.59297 Key Points Question  Can the reported potential mortality reduction by albumin replacement in septic shock be confirmed in a randomized clinical trial? Findi...

各位同事，摩洛哥麻醉、镇痛及重症医学会(SMAAR)正在进行一项国际问卷调查，旨在了解临床医生对感染性休克最初24小时的液体复苏和血流动力学支持治疗的看法与观点。 请点击以下链接 英文版 中文版 完成问卷调查大约需要5-7分钟的时间 问卷调查系自愿且匿名。提交问卷时，除非您自己提供，否则系统不会自动收集您的姓名和电子邮件地址等详细信息。 感谢您的积极参与。

LTVV and Mortality in Patients With Acute Brain Injury In ICU Wed, 19 Nov 2025 A recent study examined whether low-tidal-volume ventilation (LTVV) is associated with lower mortality in mechanically ventilated patients with acute brain injury (ABI).  LTVV has become standard care in patients with acute respiratory distress syndrome (ARDS) but its use in the ABI population remains controversial due to concerns about intracranial hypertension and the ...