ORIGINAL ARTICLE Vasopressors or Fluids in Early Septic Shock The ARISE FLUIDS Investigators, the ANZICS Clinical Trials Group, and the ACEM Clinical Trials Network N Engl J Med Published June 11, 2026 DOI: 10.1056/NEJMoa2516225 Abstract BACKGROUND The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy...

Editor's Note  Aging and Health Intensive Chemoprophylaxis for Nursing Home Influenza Outbreaks—The Race Against Transmission Justin J. Choi, Sharon K. Inouye, Lona Mody JAMA Intern Med Published Online: March 30, 2026 doi: 10.1001/jamainternmed.2026.0409 Influenza outbreaks are common and lead to morbidity in nursing home (NH) residents. To limit transmission, clinical guidelines from the US Centers for Disease Control and Prevention and the Infect...

Article Short-term light sedation with remimazolam besylate versus propofol in the ICU (SHOSREB): a multicentre, randomized, single-blind, controlled trial Yang, X., Pan, J., Gong, X. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08381-x Abstract Purpose To explore the efficacy and safety of remimazolam besylate in short-term sedation in the ICU in comparison with propofol. Method A multicenter, randomized, single-blind, non-...

Editorial  Will the Bicarbonate for In-Hospital Cardiac Arrest Trial Change Practice? Clifton W. Callaway JAMA Published Online: June 11, 2026 doi: 10.1001/jama.2026.10508 In this issue of JAMA, Granfeldt and colleagues share results of the Bicarbonate for In-Hospital Cardiac Arrest randomized clinical trial comparing routine administration of sodium bicarbonate with placebo during attempted resuscitation of 779 patients with in-hospital cardiac arrest...

Original Investigation  Caring for the Critically Ill Patient Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial Asger Granfeldt, Bertram Lahn Kirkegaard, Mikael Fink Vallentin, et al JAMA Published Online: June 11, 2026 doi: 10.1001/jama.2026.10628 Key Points Question  Does sodium bicarbonate administered during in-hospital cardiac arrest improve return of spontaneous circulation? Findings  In t...

ORIGINAL ARTICLE Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism Kenneth Rosenfield, Frederikus A. Klok, Gregory Piazza, et al N Engl J Med Published March 28, 2026 DOI: 10.1056/NEJMoa2516567 Abstract BACKGROUND Whether anticoagulation alone is an adequate treatment for acute, intermediate-risk pulmonary embolism is uncertain. METHODS We conducted a multinational, adaptive-design trial with blinded outcome adj...

Original Investigation  Aging and Health Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks Joe B. B. Silva, Han-Chih T. Hsieh, Chanelle J. Howe, et al JAMA Intern Med Published Online: March 30, 2026 doi: 10.1001/jamainternmed.2026.0401 Key Points Question  Is initiation of antiviral chemoprophylaxis with oseltamivir for 70% or more of eligible nursing home (...

Editorial  High-Dose Vitamin C in Burns: Time to Stop David G. Greenhalgh JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10573 In this issue of JAMA, Stoppe and colleagues1 present the results of an international randomized clinical trial that provides evidence that high-dose intravenous vitamin C does not improve outcomes in patients with large burns. The data from the VICTORY trial even suggest that use of vitamin C in patients with larg...

JAMA Clinical Guidelines Synopsis  Management of Acute Coronary Syndrome Adam S. Vohra, Jason T. Alexander, Atman P. Shah JAMA Published Online: March 30, 2026 doi: 10.1001/jama.2026.1214 Guideline title ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndrome Release date February 27, 2025 Prior versions 2013 and 2014 Developers American College of Cardiology (ACC), American Heart Associati...

Original Investigation  Caring for the Critically Ill Patient High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial Christian Stoppe, Aileen Hill, Leopoldo C. Cancio, et al JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10616 Key Points Question  Does high-dose intravenous vitamin C reduce a composite of 28-day mortality and persistent organ dysfunct...