ARTICLES|ONLINE FIRST Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial Mark J Peters, Doug W Gould, Samiran Ray, et al Lancet Published:December 01, 2023 DOI: https://doi.org/10.1016/S0140-6736(23)01968-2 Summary Background The optimal target for systemic oxygenation in critically ill children is unknown. Liberal oxygenation is widely practiced, bu...

ECLS in Infarct-Related Cardiogenic Shock Extracorporeal life support (ECLS) is used frequently in treating infarct-related cardiogenic shock, but there is a lack of evidence regarding its impact on mortality. In a multicentre trial involving patients with acute myocardial infarction complicated by cardiogenic shock and planned early revascularisation, participants were randomly assigned to receive ECLS along with standard medical treatment (ECLS group) or stand...

Original Investigation  November 15, 2023 Demographic Representation in 3 Leading Artificial Intelligence Text-to-Image Generators Rohaid Ali, Oliver Y. Tang, Ian D. Connolly, et al JAMA Surg. Published online November 15, 2023. doi:10.1001/jamasurg.2023.5695 Key Points Question  How accurate are 3 leading artificial intelligence (AI) text-to-image generators at representing demographic realitie...

尊敬的同事： 正如你所知，在ICU患者的诊疗过程中，包括谵妄、疼痛和镇痛、早期活动以及家属参与等因素非常重要。 2018年发布的PADIS指南为临床医生对于疼痛、镇痛及谵妄的治疗提供了指导（即所谓ABCDEF集束化治疗措施）。 2017年，我们进行了一项调查，评估全球范围内对ABCDEF集束化治疗的认知与使用。我们发现，不同国家之间ABCDEF集束化治疗措施的应用存在很大的差异。 在6年以后，特别是在新冠疫情以后，我们希望针对全球范围内ABCDEF集束化治疗措施的应用进行一项新的调查。 我们相信，这项...

Original Investigation  November 15, 2023 Transforming Team Performance Through Reimplementation of the Surgical Safety Checklist James C. Etheridge, Rachel Moyal-Smith, Tze Tein Yong, et al JAMA Surg. Published online November 15, 2023. doi:10.1001/jamasurg.2023.5400 Key Points Question  Can a systematic approach to reimplementation of an underperforming surgical safety checklist improve team behavior and performance? Finding...

ARTICLES|ONLINE FIRST Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study Cecilia A I Åkerlund, Anders Holst, Shubhayu Bhattacharyay, et al. Lancet Neurol Published: November 14, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00358-7 Summary Background Patients with traumatic brain injury are a heterogeneous population, and the most sever...

Genetically Predicted Insomnia and Risk of Sepsis Insomnia, a common sleep disorder, has been linked to various adverse health outcomes, including altered immune function and elevated systemic levels of inflammatory markers, which may affect women more than men. Dysregulated immune responses can lead to conditions like sepsis, which has high morbidity and mortality. A study was conducted to determine if insomnia is associated with risk of sepsis. Researchers als...

Original Investigation  November 15, 2023 Operative vs Nonoperative Management of Acute Cholecystitis During the Different Trimesters of Pregnancy Mariam N. Hantouli, David J. Droullard, Michael G. Nash, et al JAMA Surg. Published online November 15, 2023. doi:10.1001/jamasurg.2023.5803 Key Points Question  For pregnant patients presenting with acute cholecystitis (AC), is there a difference in adverse outcomes between those who ...

Research Christmas 2023: Marginal Gains Common Healthcare Related Instruments Subjected To Magnetic Attraction Study (CHRISTMAS): prospective in situ experimental study Shao J Ong, Koon Liang Chia, Teik Choon See, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-077164 (Published 21 December 2023)Cite this as: BMJ 2023;383:e077164 Abstract Objective To investigate the behaviour of common healthcare ...

An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline Nida Qadir,  Sarina Sahetya,  Laveena Munshi, et al Am J Respir Crit Care Med 2024; 209: 24-36 Abstract Background: This document updates previously published Clinical Practice Guidelines for the management of patients with acute respiratory distress syndrome (ARDS), incorporating new evidence addressing the...