ARTICLES| VOLUME 11, ISSUE 12, P1064-1074, DECEMBER 2023 Efficacy and safety of baricitinib or ravulizumab in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial Frances C Hall, Joseph Cheriyan, Andrew P Cope, et al Lancet Respir Med 2023; 11: 1064-1074 Published: November 14, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00376-4 Summary Background From early in the COVID-19 pandemic, evidence suggested ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalPrehospital high-dose methylprednisolone in resuscitated out-of-hospital cardiac arrest patients (STEROHCA): a randomized clinical trialObling L. E. R. et al. OriginalInflammatory subphenotypes in patients at risk of ARDS: evidence from the LIPS-A trialRedaelli S. et al. Identification of genetic profile and biomarkers involved in acute respiratory distress syndromeCao S. et al. Selective dige...

#LIVES2023: Magnesium Sulphate in Patients with Thrombotic Thrombocytopaenic Purpura Previous research has indicated the potential benefits of using magnesium sulphate in thrombotic thrombocytopaenic purpura (TTP) treatment. The goal of the Magnesium sulphate in patients with thrombotic thrombocytopenic purpura (MAGMAT) study was to assess the impact of magnesium sulphate supplementation on the recovery of patients with TTP. This was a multicentre study invo...

Original Investigation  AI in Medicine December 19, 2023 Measuring the Impact of AI in the Diagnosis of Hospitalized Patients: A Randomized Clinical Vignette Survey Study Sarah Jabbour, David Fouhey, Stephanie Shepard, et al JAMA. 2023;330(23):2275-2284. doi:10.1001/jama.2023.22295 Key Points Question  How is diagnostic accuracy impacted when clinicians are provided artificial intelligence (AI) models with image-based AI model...

Invited Commentary  November 15, 2023 Who Looks Like a Surgeon?—Evaluating Reflections From a Digital Mirror Rebecca Sorber, M. Libby Weaver JAMA Surg. Published online November 15, 2023. doi:10.1001/jamasurg.2023.5705 As the number of publicly available tools using artificial intelligence (AI) has rapidly expanded, innumerable attempts to find beneficial applications for such tools in medicine follow close behind.1 Perhaps one of the mo...

Research Letter  November 2, 2023 Changes in Employment in the US Health Care Workforce, 2016-2022 Thuy Nguyen, Christopher Whaley, Kosali I. Simon, et al JAMA. 2023;330(20):2018-2019. doi:10.1001/jama.2023.18932 The COVID-19 pandemic has caused a variety of disruptions to the health care workforce.1Data on select health care workforce sectors chronicle patterns in employment through 2021.1-3 Lack of national studies on the broad health care workf...

Research Implementation of a high sensitivity cardiac troponin I assay and risk of myocardial infarction or death at five years: observational analysis of a stepped wedge, cluster randomised controlled trial Kuan Ken Lee, Dimitrios Doudesis, Amy V Ferry, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-075009 (Published 28 November 2023)Cite this as: BMJ 2023;383:e075009 Abstract Objective To evaluate the impact of implementing a high sensitiv...

#LIVES2023: Initiation of CRRT versus IHD In critically ill patients with acute kidney injury (AKI), renal replacement therapy (RRT) is often necessary. The choice of RRT modality, such as intermittent haemodialysis (IHD) or continuous renal replacement therapy (CRRT), has been a subject of debate. IHD involves shorter, more frequent sessions, while CRRT is continuous and slower. CRRT is generally preferred for haemodynamically unstable patients, while IHD is used ...

Research Covid-19 vaccine effectiveness against post-covid-19 condition among 589 722 individuals in Sweden: population based cohort study Lisa Lundberg-Morris, Susannah Leach, Yiyi Xu, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-076990 (Published 22 November 2023)Cite this as: BMJ 2023;383:e076990 Abstract Objective To investigate the effectiveness of primary covid-19 vaccination (first two doses and first booster dose within the recomme...

ORIGINAL ARTICLE Intravenous Levothyroxine for Unstable Brain-Dead Heart Donors Rajat Dhar, Gary F. Marklin, W. Dean Klinkenberg, et al N Engl J Med 2023; 389:2029-2038DOI: 10.1056/NEJMoa2305969 BACKGROUND Hemodynamic instability and myocardial dysfunction are major factors preventing the transplantation of hearts from organ donors after brain death. Intravenous levothyroxine is widely used in donor care, on the basis of observational data suggesting that m...