ORIGINAL ARTICLE Extracorporeal Life Support in Infarct-Related Cardiogenic Shock Holger Thiele, Uwe Zeymer, Ibrahim Akin, et al N Engl J Med August 26, 2023DOI: 10.1056/NEJMoa2307227 Abstract BACKGROUND Extracorporeal life support (ECLS) is increasingly used in the treatment of infarct-related cardiogenic shock despite a lack of evidence regarding its effect on mortality. METHODS In this multicenter trial, patients with acute myocardial infarction...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Kidney Replacement Therapy in the Intensive Care Unit Kidney Replacement Therapy is a commonly used therapeutic strategy in the intensive care unit for patients who develop Acute Kidney Injury or who already have a diagnosis of chronic kidney disease. ICU staff should know when to use it and which type is most suitable for the circumstances. Epidemiology and Outcomes of AKI Acute kidney injury (AKI)...

ARTICLES|ONLINE FIRST Mortality associated with third-generation cephalosporin resistance in Enterobacterales bloodstream infections at eight sub-Saharan African hospitals (MBIRA): a prospective cohort study Alexander M Aiken, Andrea M Rehman, Marlieke E A de Kraker, et al Lancet Infect Dis Published:July 13, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00233-5 Summary Background Bacteria of the order Enterobacterales are common pathogens causing bl...

Editorials Private equity takeovers are harming patients Merrill Goozner BMJ 2023; 382 doi: https://doi.org/10.1136/bmj.p1396 (Published 19 July 2023)Cite this as: BMJ 2023;382:p1396 Evidence review suggests that costs rise and quality falls at acquired healthcare providers Private equity investment in healthcare provider institutions reached record highs in recent years in both the US and Europe, with US acquisitions accounting for three quarters of the co...

ARTICLES| VOLUME 23, ISSUE 8, P945-955, AUGUST 2023Download Full Issue Clinical impact of syndromic molecular point-of-care testing for gastrointestinal pathogens in adults hospitalised with suspected gastroenteritis (GastroPOC): a pragmatic, open-label, randomised controlled trial Nathan J Brendish, Kate R Beard, Ahalya K Malachira, et al Lancet Infect Dis 2023; 8: 945-955 Published:April 25, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00066-X ...

Diagnostic Accuracy of Monocyte Distribution Width, Procalcitonin and C‐Reactive Protein Sepsis is characterised by a dysregulated host response to infection resulting in organ dysfunction. It poses a significant global health problem, with a high mortality risk and millions of patients affected annually. Epidemiological studies have shown that nearly 20% of septic patients require mechanical ventilation, leading to significant healthcare costs. Despite clinical gu...

Original Investigation  August 15, 2023 Door-in-Door-out Times for Interhospital Transfer of Patients With Stroke Brian Stamm, Regina Royan, Mihai Giurcanu, et al JAMA. 2023;330(7):636-649. doi:10.1001/jama.2023.12739 Key Points Question  What is the median door-in-door-out time for interhospital transfer of patients with stroke, and what patient and hospital-level factors are associated with door-in-door-out time? Findings&nb...

ARTICLES|ONLINE FIRST Ultra-low tidal volume ventilation for COVID-19-related ARDS in France (VT4COVID): a multicentre, open-label, parallel-group, randomised trial Jean-Christophe Richard, Nicolas Terzi, Hodane Yonis, et al Lancet Respir Med Published:July 12, 2023DOI:https://doi.org/10.1016/S2213-2600(23)00221-7 Summary Background COVID-19-related acute respiratory distress syndrome (ARDS) is associated with a high mortality rate and longer mechanical ...

Original Investigation  Less Is More July 3, 2023 Hospital Culture and Intensity of End-of-Life Care at 3 Academic Medical Centers Elizabeth Dzeng, Jason N. Batten, Daniel Dohan, et al JAMA Intern Med. Published online July 3, 2023. doi:10.1001/jamainternmed.2023.2450 Key Points Question  What is the role of hospital culture and institutional structures in the provision of potentially nonbeneficial, high-intensity life-sustain...

OptiTHO Trial - Early NIV and HFNC-O2 vs COT and Late NIV Non-invasive ventilation (NIV) in blunt chest trauma patients without immediate life-threatening injuries is commonly used to prevent the need for endotracheal intubation. However, the actual benefits of NIV in this context have not been extensively studied. Existing literature in this field has been limited by variations in study designs, patient severity and differences in comparators. Consequently, strong...