ARTICLES| VOLUME 5, ISSUE 8, E461-E473, AUGUST 2023Download Full Issue Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY Fiona A Pearce, Sean H Lim, Mary Bythell, et al Lancet Rheumatol 2023; 5: E461-E473 Published:August, 2023 DOI:https://doi.org/10.1016/S2665-9913(23)00160-1 Summary Background In the UK, additional COVID-19 vaccine booster...

ARTICLES| VOLUME 22, ISSUE 8, P685-711, AUGUST 2023Download Full Issue Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 GBD 2019 Meningitis Antimicrobial Resistance Collaborators Lancet Neurol 2023; 22: 685-711 Published:August, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00195-3 Summary Background Although meningitis is largely preventable, it still c...

COMMENT|ONLINE FIRST Ultra-low tidal volume ventilation for lung protection: not so fast Laura A Buiteman-Kruizinga, Marcus J Schultz Lancet Respir Med Published:July 12, 2023DOI:https://doi.org/10.1016/S2213-2600(23)00225-4 Since 2000, following the publication of the ARMA study,1 low tidal volume (VT) ventilation (LTV) has been the standard of care for patients with acute respiratory distress syndrome (ARDS). LTV often refers to ventilation with VT of 6·0 mL...

ICU Management & Practice, Volume 23 - Issue 2, 2023 Predictive Analytics for Kidney Support in the ICU The timing and application of dialysis in the ICU is highly variable contributing to poor outcomes. A clinical decision support system (CDSS) incorporating a dynamic predictive algorithm for organ support could improve outcomes. Background Multiorgan failure (MOF) and acute kidney injury (AKI) are frequently encountered in critically ill patients an...

ARTICLES| VOLUME 4, ISSUE 8, E632-E641, AUGUST 2023Download Full Issue Viral and antibody dynamics of acute infection with SARS-CoV-2 omicron variant (B.1.1.529): a prospective cohort study from Shenzhen, China Yang Yang, Liping Guo, Jing Yuan, et al Lancet Microbe 2023; 8: E632-E641 Published:July 14, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00139-8 Summary Background Elucidating viral dynamics within the host is important for desig...

Editorial  July 25, 2023 Time for Acute Bacterial Rhinosinusitis Point-of-Care Testing—Snot or Not Sophie G. Shay, Jennifer J. Shin JAMA Otolaryngol Head Neck Surg. Published online July 25, 2023. doi:10.1001/jamaoto.2023.2612 The diagnosis of acute bacterial rhinosinusitis in children is clinically challenging due to symptom overlap with acute viral upper respiratory illnesses. To help address this frequent conundrum, Shaikh and colleagues d...

EDITORIAL Routine Early ECLS in Infarct-Related Cardiogenic Shock? Jane A. Leopold, Darren B. Taichman N Engl J Med August 26, 2023DOI: 10.1056/NEJMe2309395 The 30-day mortality among patients with an acute myocardial infarction complicated by cardiogenic shock who undergo coronary-artery revascularization procedures approaches 50% in contemporary clinical trials and registries.1 In patients with persistent hemodynamic compromise and organ hypoperfusion d...

ARTICLES| VOLUME 4, ISSUE 8, E591-E600, AUGUST 2023Download Full Issue Evaluating the relationship between community water and sanitation access and the global burden of antibiotic resistance: an ecological study Erica R Fuhrmeister, Abigail P Harvey, Maya L Nadimpalli, et al Lancet Microbe 2023; 4: E591-E600 Published:June 30, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00137-4 Summary Background Antibiotic resistance is a leading c...

Editorial  July 25, 2023 Acute Bacterial Sinusitis: Limitations of Test-Based Treatment Tania M. Caballero, Brandon S. A. Altillo, Aaron M. Milstone JAMA. 2023;330(4):326-327. doi:10.1001/jama.2023.11365 Millions of cases of upper respiratory tract infections (URTIs) occur in the US each year and are more common among children than adults. Most URTIs are viral in origin and self-limited, but up to 50% of all patient encounters for viral URTI ...

ORIGINAL ARTICLE Health Consequences of Thymus Removal in Adults Kameron A. Kooshesh, Brody H. Foy, David B. Sykes, et al N Engl J Med 2023; 389:406-417DOI: 10.1056/NEJMoa2302892 Abstract BACKGROUND The function of the thymus in human adults is unclear, and routine removal of the thymus is performed in a variety of surgical procedures. We hypothesized that the adult thymus is needed to sustain immune competence and overall health. METHODS We evalua...