Mechanical Ventilation Across Countries Invasive mechanical ventilation (IMV) is a crucial component of intensive care in modern healthcare. However, it remains uncertain whether the rates of IMV usage differ between countries. A recent study analysed data from 2018, focusing on patients aged 20 years and above who underwent IMV in England, Canada, and the United States. The study aimed to determine the per capita rates of IMV in adults within these three high-i...

Original Investigation  September 5, 2023 Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke: The OPTIMAL-BP Randomized Clinical Trial Hyo Suk Nam, Young Dae Kim, JoonNyung Heo, et al JAMA. 2023;330(9):832-842. doi:10.1001/jama.2023.14590 Key Points Question  Does early intensive blood pressure management improve outcomes after successful reperfusion with endovascular thromb...

Original Investigation  Caring for the Critically Ill Patient October 10, 2023 Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs: A Randomized Clinical Trial Susan S. Huang, Edward J. Septimus, Ken Kleinman, et al JAMA. 2023;330(14):1337-1347. doi:10.1001/jama.2023.17219 Key Points Question  Does nasal iodophor ...

Original Investigation  September 5, 2023 Blood Pressure Management After Endovascular Therapy for Acute Ischemic Stroke: The BEST-II Randomized Clinical Trial Eva A. Mistry, Kimberly W. Hart, Larry T. Davis, et al JAMA. 2023;330(9):821-831. doi:10.1001/jama.2023.14330 Key Points Question  Are moderately low systolic blood pressure (SBP) targets (<140 and <160 mm Hg) after successful endovascular stroke treatment harmful? ...

Original Investigation  September 5, 2023 Defining Usual Oral Temperature Ranges in Outpatients Using an Unsupervised Learning Algorithm Catherine Ley, Frederik Heath, Trevor Hastie, et al JAMA Intern Med. Published online September 5, 2023. doi:10.1001/jamainternmed.2023.4291 Key Points Question  Can personalized temperature norms be defined to improve the clinical utility of oral temperature measur...

Avoiding Harm When Feeding Critically Ill Patients Nutrition in critical illness has become a significant area of focus in recent decades. Initially, early and adequate feeding was believed to enhance outcomes by promptly ensuring the patient reaches full energy target. However, this perspective was challenged after the release of the EPaNIC trial in 2011. The EPaNIC trial observed worse outcomes in patients who received early supplemental parenteral nutrition (...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalEchocardiography phenotypes of right ventricular involvement in COVID-19 ARDS patients and ICU mortality: post-hoc (exploratory) analysis of repeated data from the ECHO-COVID studyHuang S.. et al. Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsisReilly J.P. et al.  OPEN ACCESSTowards model-informed precision dosing of piperacillin: multicenter systematic external evaluat...

ARTICLES| VOLUME 23, ISSUE 9, P1031-1041, SEPTEMBER 2023Download Full Issue All-cause and pathogen-specific lower respiratory tract infection hospital admissions in children younger than 5 years during the COVID-19 pandemic (2020–22) compared with the pre-pandemic period (2015–19) in South Africa: an observational study Alane Izu, Marta C Nunes, Fatima Solomon, et al. Lancet Infect Dis 2023; 23: 1031-1041 Published: May 01, 2023 DOI:https://doi....

Influence of Gender on Age-Associated Mortality in Sepsis Despite advancements in medical care, sepsis remains a significant global health issue and a leading cause of hospital mortality worldwide. Numerous epidemiological studies have been conducted on sepsis, but its epidemiology remains unclear due to its heterogeneous nature. Sepsis is characterised by an imbalanced immune response to infection. Most studies on mortality risk factors in sepsis primarily focu...

ARTICLES|ONLINE FIRST Trends in invasive Haemophilus influenzae serotype a disease in England from 2008–09 to 2021–22: a prospective national surveillance study Marta Bertran, Joshua C D'Aeth, Erjola Hani, et al Lancet Infect Dis Published:June 22, 2023DOI:https://doi.org/10.1016/S1473-3099(23)00188-3 Summary Background Invasive Haemophilus influenzae serotype a (Hia) disease is rare, with most cases reported among Indigenous populati...