ARTICLES|ONLINE FIRST Clarithromycin for early anti-inflammatory responses in community-acquired pneumonia in Greece (ACCESS): a randomised, double-blind, placebo-controlled trial Evangelos J Giamarellos-Bourboulis, Athanasios Siampanos, Amalia Bolanou, et al Lancet Respir Med Published: January 03, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00412-5 Summary Background Addition of macrolide antibiotics to β-lactam antibiotics for the treatment of ...

Perspective Secondary Cancers after Chimeric Antigen Receptor T-Cell Therapy Nicole Verdun, Peter Marks N Engl J Med January 24, 2024DOI: 10.1056/NEJMp2400209 Since the first such product was approved in 2017, chimeric antigen receptor (CAR) T-cell therapies have become important treatments for relapsed or refractory hematologic cancers, and the six products involving autologous CAR T cells that have been approved in the United States now cover a range of ind...

ARTICLES|ONLINE FIRST Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial Achim J Kaasch, Luis Eduardo López-Cortés, Jesús Rodríguez-Baño, et al Lancet Infect Dis Published: January 17, 2024 DOI: https://doi.org/10.1016/S1473-3099(23)00756-9 Summary Background Staphylococcus aureus bloodst...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Towards Artificial Intelligence as a Decision Support Tool to Combat AMR in the ICU Ongoing research and challenges regarding the use of Artificial Intelligence and Machine Learning to leverage data and identify complex interactions to address antimicrobial resistance in the ICU. The possibilities of artificial intelligence (AI), and more specifically, machine learning (ML), are being researched across...

ARTICLES|ONLINE FIRST Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial Luis Eduardo López-Cortés, Mercedes Delgado-Valverde, Elisa Moreno-Mellado, et al Lancet Infect Dis Published: January 09, 2024 DOI: https://doi.org/10.1016/S1473-3099(23)00686-2 Summary Background De-escalation from broad-spectrum to narrow-spe...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Ethics in Surgical Education Research Michael M. Awad, Amy H. Kaji, Timothy M. Pawlik JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6705 Introduction Rigorous and well-designed research is integral to advance surgical education science. In contrast to clinical research in which study participants are patients, surgica...

ARTICLES|ONLINE FIRST Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial Yin Mo, Suchart Booraphun, Andrew Yunkai Li, et al Lancet Respir Med Published: January 22, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00418-6 Summary Background Ventilator-associated pneumonia (VAP) is associated with ...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Seven Myths of Mechanical Ventilation in Paediatric and Neonatal Patients In this article, we will examine clinical concepts that have persisted over time, despite advancements in our understanding of physiology and technological innovations that have demonstrated their inapplicability in the routine clinical care of paediatric patients requiring respiratory support. These enduring beliefs have effectivel...

Research Letter  December 28, 2023 Lifting of Embargoes to Data Sharing in Clinical Trials Published in Top Medical Journals Maximilian Siebert, John P. A. Ioannidis JAMA. 2024;331(4):354-355. doi:10.1001/jama.2023.25394 Data sharing in clinical trials enhances trust and reproducibility and allows secondary analyses.1 However, sharing of clinical trials data is the exception rather than the rule2 and is often limited by embargoes, which const...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Education Program Evaluation Research Marc de Moya, Jason S. Haukoos, Kamal M. F. Itani JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6702 Introduction Program evaluation is the systematic assessment of a program’s implementation. In medical education, evaluation includes the synthesis and analysis of educational prog...