ARTICLES| VOLUME 22, ISSUE 11, P1005-1014, NOVEMBER 2023 Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label, randomised controlled superiority trial Jean-François Payen, Yoann Launey, Russell Chabanne, et al Lancet Neurol 2023; 22: 1005-1014 Published: November, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00290-9 Summary Background Optimisatio...

Research Pharmaceutical industry payments and delivery of non-recommended and low value cancer drugs: population based cohort study Aaron P Mitchell, Stacie B Dusetzina, Akriti Mishra Meza, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-075512 (Published 25 October 2023)Cite this as: BMJ 2023;383:e075512 Abstract Objective To estimate the association between oncologists’ receipt of payments from the pharmaceutical industry and delivery of no...

Single-Plane vs Real-Time Biplane Approaches for Ultrasound-Guided CVC Central venous catheterisation (CVC) is a lifesaving procedure for critically ill patients, commonly used during fluid resuscitation, safe intravenous administration of medication, and to facilitate haemodialysis and monitor haemodynamic variables in the ICU. Over 15 million CVCs are performed annually in the United States, and nearly 70 CVCs per 100 patient-days are performed in European I...

Editor's Note  October 30, 2023 Gender Equity in Clinical Trial Leadership—A Win-Win for Everyone Grace Y. Zhang, Ishani Ganguli, Tracy Y. Wang JAMA Intern Med. Published online October 30, 2023. doi:10.1001/jamainternmed.2023.5091 Gender disparity in clinical trial leadership has been described previously in fields such as cardiology.1 In this issue of JAMA Internal Medicine, Waldhorn et al2 demonstrate that this issue is more...

Original Investigation  October 23, 2023 Multitarget Stool RNA Test for Colorectal Cancer Screening Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, et al JAMA. Published online October 23, 2023. doi:10.1001/jama.2023.22231 Key Points Question  What is the performance of the novel multitarget stool RNA (mt-sRNA) test (ColoSense) for individuals 45 years and older undergoing colorectal ca...

A Case Study in Artificial Intelligence-Generated Manuscripts Michael N. Kammer Chest 2023; 164: 478-480 DOI:https://doi.org/10.1016/j.chest.2023.05.003 “Write a review article on the use of bronchoscopy to diagnose lung cancer, use scientific vocabulary, cite your sources.” Text started to scroll across the screen; it was well written, plausible, and generated by artificial intelligence (AI), the newest tool based on the generative pretrained transformer mode...

Ventilator-Induced Lung Injury and the Circadian Clock Patients diagnosed with acute respiratory distress syndrome (ARDS) often require mechanical ventilation (MV) as a life-saving intervention. However, mechanical ventilation can aggravate lung injury, leading to a condition known as ventilator-induced lung injury (VILI). Although using low tidal volume (VT) ventilation has become the standard in clinical practice for patients with ARDS, lung-protective ventila...

Research Letter  October 30, 2023 Gender Gap in Leadership of Clinical Trials Ithai Waldhorn, David Bomze, Irit Ben-Aharon, et al JAMA Intern Med. Published online October 30, 2023. doi:10.1001/jamainternmed.2023.5104 Clinical trials provide the highest-quality evidence and remain the bedrock for clinical decision-making. They require participation of numerous patients, enormous resources, and substantial fu...

Consensus Statement  Infectious Diseases July 31, 2023 Guidelines for Diagnosis and Management of Infective Endocarditis in Adults: A WikiGuidelines Group Consensus Statement Emily G. McDonald, Gloria Aggrey, Abdullah Tarık Aslan, et al JAMA Netw Open. 2023;6(7):e2326366. doi:10.1001/jamanetworkopen.2023.26366 Key Points Question  Using the WikiGuidelines approach to the construct of clinical...

Corticosteroids in Severe CAP Corticosteroid use in the care of critically ill patients has been the subject of ongoing research with conflicting findings. There is a growing interest in understanding their role in treating a common source of sepsis: community-acquired pneumonia (CAP). Some studies have focused on determining whether corticosteroids provide clinical benefits to patients with the most severe clinical presentation and highest mortality rate of C...