Host Gene Expression Signatures in Children Evaluated for Sepsis Findings presented at #ISICEM24 show that novel host transcriptomic signatures specific for bacterial and viral infection in children evaluated for sepsis can identify dysregulated host response leading to organ dysfunction.  The goal of the study was to create gene expression signatures in children with bacterial or viral infections to predict organ dysfunction, as current biomarkers for seps...

Editorial  March 19, 2024 Oxygen Supplementation in COVID-19—How Much Is Enough? Richard M. Schwartzstein JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.2935 Humans are aerobic animals; we need oxygen to support metabolism and generate energy. Simply put, breathing oxygen is necessary for life. Consequently, it would make sense that diseases that inhibit the transfer of oxygen from the lung to the blood should be treat...

Safe Application of Early Active Mobilisation - ISICEM 2024 Findings from a systematic review on early mobilisation were presetned at #ISICEM24. The findings were just published in Lancet Respiratory Medicine.  Recent clinical practice guidelines have incorporated mobilisation during critical illness. Yet, findings from a significant randomised trial and systematic review suggest a higher likelihood of adverse events and mortality in patients receiving earl...

Original Investigation  Caring for the Critically Ill Patient March 19, 2024 Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults Kevin G. Buell, Alexandra B. Spicer, Jonathan D. Casey, et al JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.2933 Key Points Question  Among critically ill adults, do the effects of peripheral oxygen-saturation (Spo2) targets on outcomes d...

ISICEM 2024 Begins! The 43rd International Symposium on Intensive Care and Emergency Medicine (ISICEM) opened today in Brussels. The Congress will feature over 600 presentations in the next four days, covering a wide array of topics and providing valuable insights to contribute to the mission of advancing critical care worldwide. As highlighted during the opening ceremony, ISICEM is a testament to the dedication of its scientific advisors, the hard work of t...

Original Investigation  Caring for the Critically Ill Patient March 19, 2024 Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial Frederik M. Nielsen, Thomas L. Klitgaard, Martin Siegemund, et al JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.2934 Key Points Question  Does targeting a Pao2 of 60 mm Hg vs 90 mm Hg affect the number of days...

Return to Work After Hospitalisation for Sepsis This study focuses on the impact of sepsis, a condition resulting from a dysregulated immune response to infection, on the ability of patients to return to work (RTW). Sepsis is a significant global health concern, causing substantial morbidity and mortality. Sepsis survivors commonly experience long-term cognitive and functional impairments, but the effect on their ability to resume work is not well understood. RT...

Original Investigation  Infectious Diseases January 2, 2024 Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections Drew W. Engers, Pranita D. Tamma, Suiyini Fiawoo, et al JAMA Netw Open. 2024;7(1):e2349864. doi:10.1001/jamanetworkopen.2023.49864 Key Points Question  What is the timeline of transition from intravenous (IV) to oral antibiotics among patients with gram-negative blo...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalVenous thromboembolism in critically ill adult patients with hematologic malignancy: a population-based cohort studyCarini F. C. et al. OPEN ACCESS ~ OriginalAcute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trialMeersch M. et al Long-term outcomes with haloperidol versus placebo in acutely admitted adult ICU patients with deliriumBekker Mortensen C. et al. Phase-3 ...

Research Letter  Equity, Diversity, and Inclusion January 11, 2024 Characteristics of Medical School Deans and University Hospital Directors in Japan Takashi Watari, Ashwin Gupta, Maika Hayashi, et al JAMA Netw Open. 2024;7(1):e2351526. doi:10.1001/jamanetworkopen.2023.51526 Introduction Medical school deans and university hospital directors are pivotal high-ranking leaders in health care organizations, exerting profound influence on th...