Original Investigation  January 17, 2023 Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial Robert J. Mentz, Kevin J. Anstrom, Eric L. Eisenstein, et al JAMA. 2023;329(3):214-223. doi:10.1001/jama.2022.23924 Key Points Question  Does torsemide reduce all-cause mortality compared with furosemide in patients with heart fail...

Original Investigation  February 8, 2024 Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: The MARVEL Randomized Clinical Trial MARVEL Trial Authors for the MARVEL Investigators JAMA. Published online February 8, 2024. doi:10.1001/jama.2024.0626 Key Points Question  Among patients with large-vessel occlusion acute ischemic stroke, does adjunctive intravenous methylprednisolone added to ...

Original Investigation  February 7, 2024 Health Insurance Status and Unplanned Surgery for Access-Sensitive Surgical Conditions Shukri H. A. Dualeh, Sara L. Schaefer, Nicholas Kunnath, et al JAMA Surg. Published online February 7, 2024. doi:10.1001/jamasurg.2023.7530 Key Points Question  What is the association between health insurance status and rates and outcomes of unplanned surgery for ac...

ARTICLES|ONLINE FIRST Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial Nicholas Heming, Alain Renault, Emmanuelle Kuperminc, et al Lancet Respir Med Published:February 01, 2024 DOI:https://doi.org/10.1016/S2213-2600(23)00430-7 Summary Background Glucocorticoids probably improve outcomes in patients hospitalised for community acquired pneumonia (CAP)...

Change in Research Focus for Early Nutrition In ICU Thu, 21 Mar 2024 In an interesting session today at #ISICEM24, Dr Annika Reintam Blaser, an intensivist at Lucerne Cantonal Hospital in Switzerland, discussed future research on optimising feeding for critically ill patients. She highlighted the accumulating evidence over the past 15 years suggesting that feeding might have harmful effects on critically ill patients. Dr Blaser challenged the intuit...

Plasma Metabolomics Reveals Distinct Biological and Diagnostic Signatures for Melioidosis Lu Xia,  Viriya Hantrakun,  Prapit Teparrukkul, et al Am J Respir Crit Care Med 2024; 209: 288-298 DOI: 10.1164/rccm.202207-1349OC Abstract Rationale: The global burden of sepsis is greatest in low-resource settings. Melioidosis, infection with the gram-negative bacterium Burkholderia pseudomallei, is a frequent cause of fatal sepsis in en...

Editorials Use of generative artificial intelligence in medical research Nazrul Islam, Mihaela van der Schaar BMJ 2024; 384 doi: https://doi.org/10.1136/bmj.q119 (Published 31 January 2024)Cite this as: BMJ 2024;384:q119 Policies must be standardised to ensure accountability and maintain public trust Among the most groundbreaking advancements in artificial intelligence (AI) is the emergence of generative AI. These models, ...

COMMENT|ONLINE FIRST Bacterial antimicrobial resistance burden in Africa: accuracy, action, and alternatives Sabiha Y Essack, Annick Lenglet Lancet Glob Health Published: December 19, 2023 DOI:https://doi.org/10.1016/S2214-109X(23)00587-9 Understanding the burden of antimicrobial resistance (AMR), detecting potential hospital outbreaks due to multidrug resistant-bacteria, and monitoring local, regional, and global trends of bacterial resistance for the earl...

Just Published: The HOT-COVID Clinical Trial - ISICEM 2024 In ICU Tue, 19 Mar 2024 Findings from the HOT-COVID Randomised Clinical Trial, just published in JAMA, were presented at #ISICEM24.  COVID-19 pneumonia often leads to hypoxaemic respiratory failure, necessitating high levels of supplemental oxygen and intensive care. Previous recommendations suggested maintaining peripheral oxygen saturation (Spo2) between 90% and 96%. However, uncertai...

Editorial  March 19, 2024 Your Mileage May Vary: Toward Personalized Oxygen Supplementation Derek C. Angus JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.0972 When car makers tout standard emission tests to demonstrate their car’s fuel efficiency, they must disclose that the results are just estimates and that a prospective buyer’s experience may differ.1 The phrase. “your mileage may vary” is used to acknowledge that the a...