ORIGINAL ARTICLE Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection Gregory W. Albers, Mouhammad Jumaa, Barbara Purdon, et al N Engl J Med 2024; 390:701-711DOI: 10.1056/NEJMoa2310392 Abstract BACKGROUND Thrombolytic agents, including tenecteplase, are generally used within 4.5 hours after the onset of stroke symptoms. Information on whether tenecteplase confers benefit beyond 4.5 hours is limited. METHODS We conducted a mul...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 165, ISSUE 2, P348-355, FEBRUARY 2024 Peripheral Administration of Norepinephrine: A Prospective Observational Study Jason R. Yerke, Eduardo Mireles-Cabodevila, Alyssa Y. Chen, et al Chest 2024; 165: 348-355 Published:August 20, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.019 Background Historically, norepinephrine has been administered through a central venous catheter (CVC) because of concerns about the risk o...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 165, ISSUE 2, P333-347, FEBRUARY 2024 Low Tidal Volume Ventilation Is Poorly Implemented for Patients in North American and United Kingdom ICUs Using Electronic Health Records Romit J. Samanta, Ari Ercole, Steven Harris, et al Chest 2024; 165: 333-347 Published:September 27, 2023 DOI:https://doi.org/10.1016/j.chest.2023.09.021 Background Low tidal volume ventilation (LTVV; < 8 mL/kg predicted body weight...

Cardiovascular Management in Septic Shock: Optimising Vascular and Cardiac Function An overview of vasopressor management, current evidence on its use, when to initiate vasopressor therapy for best possible patient outcome and a discussion regarding the use of landiolol in septic patients with persistent tachycardia.   Optimising Vasopressin Initiation in Septic Shock Patients with septic shock, and especially those with high vasopressor needs, are at r...

Medical News & Perspectives  Quick Uptakes February 14, 2024 When It Comes to SARS-CoV-2 Clearance, People Who are Immunocompromised Are Not All Alike Rita Rubin JAMA. Published online February 14, 2024. doi:10.1001/jama.2024.1014 For people who are immunocompromised, the COVID-19 pandemic is not over. In general, their immune system’s response to COVID-19 vaccines and to SARS-CoV-2 infection is blunted compared with individuals who...

Original Investigation  January 30, 2024 Neurodevelopmental Outcomes of Extremely Preterm Infants Fed Donor Milk or Preterm Infant Formula: A Randomized Clinical Trial Tarah T. Colaizy, Brenda B. Poindexter, Scott A. McDonald, et al JAMA. 2024;331(7):582-591. doi:10.1001/jama.2023.27693 Key Points Question  Among extremely preterm infants fed minimal maternal milk, does feeding of donor human milk compared with preterm formula du...

Original Investigation  Pediatrics February 14, 2024 Hospital-Level NICU Capacity, Utilization, and 30-Day Outcomes in Texas David C. Goodman, Patrick Stuchlik, Cecilia Ganduglia-Cazaban, et al JAMA Netw Open. 2024;7(2):e2355982. doi:10.1001/jamanetworkopen.2023.55982 Key Points Question  Is hospital-level neonatal intensive care unit (NICU) bed supply associated with higher risk-adjusted newborn utilization and better outcome...

VENT-AVOID Trial: ECCO2R to Avoid IMV During Exacerbation of COPD In patients experiencing exacerbation of chronic obstructive pulmonary disease (ECOPD), invasive mechanical ventilation (IMV) is linked with increased morbidity and mortality. Extracorporeal CO2removal (ECCO2R) has been used to prevent intubation in those at risk of NIV failure and to aid early extubation from IMV. However, current evidence supporting the efficacy of ECCO2R devices in reducing or avo...

Original Investigation  Medical Education February 14, 2024 Effectiveness of Virtual Reality Training in Teaching Personal Protective Equipment Skills: A Randomized Clinical Trial Keisuke Tsukada, Youichi Yasui, Satoshi Miyata, et al JAMA Netw Open. 2024;7(2):e2355358. doi:10.1001/jamanetworkopen.2023.55358 Key Points Question  Is virtual reality (VR) training effective in teaching donning and doffing of personal protective eq...

Original Investigation  February 20, 2024 Examining Excess Mortality Associated With the COVID-19 Pandemic for Renters Threatened With Eviction Nick Graetz, Peter Hepburn, Carl Gershenson, et al JAMA. 2024;331(7):592-600. doi:10.1001/jama.2023.27005 Key Points Question  What were the patterns of excess mortality associated with the COVID-19 pandemic among renters who received eviction filings? Findings  In this retro...