Managing Radiation Exposure in ICU Imaging  In ICU Tue, 9 Sep 2025 Imaging is integral to intensive care, where frequent X-rays, fluoroscopy, CT and nuclear medicine guide day-to-day decisions for critically ill patients. Repeated examinations during prolonged admissions can drive cumulative effective dose to levels that warrant careful management, with CT the dominant contributor. Safe delivery relies on robust justification, disciplined optimisa...

Original Investigation Caring for the Critically Ill Patient Levosimendan to Facilitate Weaning From ECMO in Patients With Severe Cardiogenic Shock: The LEVOECMO Randomized Clinical Trial Alain Combes, Ouriel Saura, Nicolas Nesseler, et al JAMA Published Online: December 1, 2025 doi: 10.1001/jama.2025.19843 Key Points Question  In patients with severe but potentially reversible cardiogenic shock w...

Original Investigation  Pharmacy and Clinical Pharmacology Trimethoprim-Sulfamethoxazole and Acute Respiratory Failure in Adolescents and Young Adults Fatemeh Ahmadi, Eric McArthur, Facundo Garcia-Bournissen, et al JAMA Netw Open 2025;8;(11):e2545251. doi:10.1001/jamanetworkopen.2025.45251 Key Points Question  Is the use of trimethoprim-sulfamethoxazole (TMP-SMX) associated with an increased 30-day risk of hospital visits for acute respira...

CLINICAL INVESTIGATION Phenylephrine Vs. Norepinephrine on the Renin–Angiotensin–Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial Chen, Junda; Wang, Xinghe; Yin, Tianyu; et al Crit Care Med 2025; 53(12): e2629-e2641 DOI: 10.1097/CCM.0000000000006912 Objectives:  This study aimed to explore how phenylephrine (PE) and norepinephrine (NE) affect renin–angiotensin–aldosterone system (RA...

Original Investigation  Pediatrics Hospital Admissions After Early-Onset Neonatal Bacterial Infection Management Guidelines in France Léna Paucard, Bérénice Varga, Elsa Kermorvant-Duchemin, et al JAMA Netw Open 2025;8;(11):e2545436. doi:10.1001/jamanetworkopen.2025.45436 Key Points Question  Were the 2017 French guidelines on early-onset neonatal bacterial infections (EONIs), which replaced systematic mic...

Peripheral Vasopressor Use for Sepsis-Induced Hypotension In Sepsis Wed, 10 Sep 2025 Vasopressors are standard therapy for sepsis-induced hypotension and shock, traditionally given via central venous catheters (CVCs) due to concerns about tissue injury from peripheral intravenous catheter (PIV) extravasation. Recent studies, however, suggest that peripheral vasopressors are safe, with low extravasation rates and minimal tissue injury, while offering ad...

Original Investigation  Changes in Health Care Use and Outcomes After Turnover in Primary Care Adrienne H. Sabety, Anupam B. Jena, Michael L. Barnett JAMA Intern Med 2021;181;(2):186-194 doi:10.1001/jamainternmed.2020.6288 Key Points Question  What is the association of health care use and outcomes with the loss of a primary care physician? Findings  In this cohort study of 359 470 Medicare beneficiari...

ORIGINAL ARTICLE Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis Charmaine E. Lok, Michael Farkouh, Brenda R. Hemmelgarn, et al N Engl J Med Published November 7, 2025 DOI: 10.1056/NEJMoa2513032 Abstract BACKGROUND Cardiovascular disease is the leading cause of death in patients receiving hemodialysis, yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated fatty acids, especial...

CRITICAL CARE: ORIGINAL RESEARCH Oxygen Saturation Targets and Neurologic Outcomes Following Cardiac Arrest: A Secondary Analysis of the Pragmatic Investigation of Optimal Oxygen Targets Trial Stephanie C. DeMasi, Alexander T. Clark, Amelia L. Muhs, et al Chest 2025; 168: 1131-1140 DOI: 10.1016/j.chest.2025.04.027 External Link Abstract Background More than 600,000 adults in the United States experience an out-of-hospital or in-hospital cardiac arrest...

Plasma Proteomics to Identify Molecular Subtypes in Sepsis In Sepsis Thu, 4 Sep 2025 Sepsis remains a leading cause of ICU mortality, with therapeutic progress limited to infection control and supportive care, as molecularly targeted treatments have failed in clinical trials due to the syndrome’s heterogeneity. Personalised medicine requires accurate biomarkers and mechanistic insights, and mass spectrometry–based plasma proteomics offers a promising a...