ARTICLES|ONLINE FIRST Oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China: a multicentre, double-blind, phase 3, randomised controlled study Xiaohong Fan, Xiahong Dai, Yun Ling, et al. Lancet Infect Dis Published: November 22, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00577-7 Summary Background Spread of SARS-CoV-2 led to a global pandemic, and there remains unmet medical needs in the treatment of Omicron infections. VV1...

Feature Christmas 2023: Champagne Problems Cheers not tears: champagne corks and eye injury Ethan Waisberg, Joshua Ong, Mouayad Masalkhi, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj.p2520 (Published 20 December 2023)Cite this as: BMJ 2023;383:p2520 Be careful this holiday season: ocular trauma while opening bottles of fizz can be significant—and easily avoided, advise Ethan Waisberg and colleagues The joyful effervescence of champagne is ...

Deaths From Neonatal Sepsis and the Need to Improve Treatment A global observational study jointly led by University College London (UCL) has revealed a concerning trend in the effectiveness of antibiotics to treat sepsis in newborn babies. The study, conducted across 19 hospitals in 11 countries and involving over 3,200 infants with sepsis, found a high mortality rate among infants with culture-positive sepsis (nearly 1 in 5 infants). The study is published i...

Research Christmas 2023: Annual leave Retail demand for emergency contraception in United States following New Year holiday: time series study Brandon Wagner, Kelly Cleland BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-077437 (Published 20 December 2023)Cite this as: BMJ 2023;383:e077437 Abstract Objective To estimate the increase in sales of emergency contraception following the New Year’s Eve/New Year’s Day holiday. Design Time ser...

ARTICLES|ONLINE FIRST Efficacy and safety of rezafungin and caspofungin in candidaemia and invasive candidiasis: pooled data from two prospective randomised controlled trials George R Thompson III, Alex Soriano, Patrick M Honore, et al Lancet Infect Dis Published:November 23, 2023 DOI: https://doi.org/10.1016/S1473-3099(23)00551-0 Summary Background Rezafungin, a new US Food and Drug Administration-approved, long-acting echinocandin to treat cand...

Research Christmas: Workforce crisis Analysis of Barbie medical and science career dolls: descriptive quantitative study Katherine Klamer BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-077276 (Published 18 December 2023)Cite this as: BMJ 2023;383:e077276 Abstract Objectives To identify Barbie brand dolls that had medicine and science themed professions in comparison with other career dolls and to determine their accuracy in meeting clinical a...

Editorial  December 1, 2023 Prone Positioning During Venovenous ECMO for Severe ARDS Ricardo Teijeiro-Paradis, Niall D. Ferguson JAMA. Published online December 1, 2023. doi:10.1001/jama.2023.22456 Care of patients with severe hypoxemic respiratory failure receiving mechanical ventilation has advanced significantly in the last 25 years due to a focus on minimization of iatrogenic injury, largely ventilator-induced lung injury. In addition to ...

Original Investigation  December 4, 2023 Photobiomodulation Therapy to Treat Snakebites Caused by Bothrops atrox: A Randomized Clinical Trial Érica da Silva Carvalho, Andrea Renata do Nascimento Souza, Dessana Francis Chehuan Melo, et al JAMA Intern Med. Published online December 4, 2023. doi:10.1001/jamainternmed.2023.6538 Key Points Question  What is the feasibility, safety, and efficacy of low-level laser therapy (LLLT) in red...

Research Christmas 2023: Workforce Crisis Effect of a doctor working during the festive period on population health: natural experiment using 60 years of Doctor Who episodes (the TARDIS study) Richard D Riley BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-077143 (Published 18 December 2023)Cite this as: BMJ 2023;383:e077143 Abstract Objective To examine the effect of a (fictional) doctor working during the festive period on populati...

Feature Christmas 2023: Champagne Problems Bug in a mug: are hospital coffee machines transmitting pathogens? Sarah Victoria Walker, Alessa Lalinka Boschert, Martina Wolke, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj.p2564 (Published 18 December 2023)Cite this as: BMJ 2023;383:p2564 For many, coffee is the elixir of life. But is it also a cradle of life?Sarah Victoria Walker and colleaguespeer into the depths of the hospital coffee machine Cof...