Original Investigation  December 12, 2023 Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Early Pregnancy: The MOMPOD Randomized Clinical Trial Kim A. Boggess, Arielle Valint, Jerrie S. Refuerzo, et al JAMA. 2023;330(22):2182-2190. doi:10.1001/jama.2023.22949 Key Points Question  Does metformin added to insulin for the treatment of preexisting type 2 diabetes or diabetes identified early in pregnancy re...

Original Investigation  November 11, 2023 Aspirin and Hemocompatibility Events With a Left Ventricular Assist Device in Advanced Heart Failure: The ARIES-HM3 Randomized Clinical Trial Mandeep R. Mehra, Ivan Netuka, Nir Uriel, MD, et al JAMA. 2023;330(22):2171-2181. doi:10.1001/jama.2023.23204 Key Points Question  Can aspirin be safely avoided as part of an antithrombotic regimen including a vitamin K antagonist with a fully magnetically le...

IMMUNOCITRE Trial - Enteral L-citrulline Administration vs Placebo Critically ill patients admitted to the ICU often experience temporary immune deficiencies, leading to persistent organ dysfunction and a higher risk of ICU-acquired infections. Researchers have been exploring immune-enhancing diets to address these issues, focusing on nutrients like L-arginine. L-arginine is important because it can become deficient in critically ill patients and is associated with...

Original Investigation  Caring for the Critically Ill Patient November 29, 2023 Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial Yonathan Freund, Damien Viglino, Marine Cachanado, et al JAMA. Published online November 29, 2023. doi:10.1001/jama.2023.24391 Key Points Question  In patients with suspected poisoning and Glasgow Coma Scale score less than 9, is a conservative ai...

Research Social media use and health risk behaviours in young people: systematic review and meta-analysis Amrit Kaur Purba, Rachel M Thomson, Paul M Henery, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2022-073552 (Published 29 November 2023)Cite this as: BMJ 2023;383:e073552 Abstract Objectives To examine the association between social media use and health risk behaviours in adolescents (defined as those 10-19 years). Design Systematic...

Research Air pollution deaths attributable to fossil fuels: observational and modelling study Jos Lelieveld, Andy Haines, Richard Burnett, et al BMJ 2023; 383 doi: https://doi.org/10.1136/bmj-2023-077784 (Published 29 November 2023)Cite this as: BMJ 2023;383:e077784 Abstract Objectives To estimate all cause and cause specific deaths that are attributable to fossil fuel related air pollution and to assess potential health benefits from policies that rep...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Cardiovascular Management in Sepsis: Improving Cardiac and Vascular Functions Vasopressin and landiolol are critical therapies for ensuring the vascular and cardiac systems are as close to optimal conditions as possible during septic shock. Better cardiovascular management in septic shock can help improve septic shock management. Sepsis is a life-threatening organ dysfunction caused by a dysregulated h...

ARTICLES|ONLINE FIRST Blood eosinophil-guided oral prednisolone for COPD exacerbations in primary care in the UK (STARR2): a non-inferiority, multicentre, double-blind, placebo-controlled, randomised controlled trial Sanjay Ramakrishnan, Helen Jeffers, Beverly Langford-Wiley, et al. Lancet Respir Med Published: November 01, 2023 DOI:https://doi.org/10.1016/S2213-2600(23)00298-9 Summary Background Systemic glucocorticoids are recommended for use in chr...

ARTICLES|ONLINE FIRST Conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU): a UK multicentre, open, parallel-group, randomised clinical trial Mark J Peters, Doug W Gould, Samiran Ray, et al Lancet Published:December 01, 2023 DOI: https://doi.org/10.1016/S0140-6736(23)01968-2 Summary Background The optimal target for systemic oxygenation in critically ill children is unknown. Liberal oxygenation is widely practiced, bu...

ECLS in Infarct-Related Cardiogenic Shock Extracorporeal life support (ECLS) is used frequently in treating infarct-related cardiogenic shock, but there is a lack of evidence regarding its impact on mortality. In a multicentre trial involving patients with acute myocardial infarction complicated by cardiogenic shock and planned early revascularisation, participants were randomly assigned to receive ECLS along with standard medical treatment (ECLS group) or stand...