ARTICLES|ONLINE FIRST Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial Luis Eduardo López-Cortés, Mercedes Delgado-Valverde, Elisa Moreno-Mellado, et al Lancet Infect Dis Published: January 09, 2024 DOI: https://doi.org/10.1016/S1473-3099(23)00686-2 Summary Background De-escalation from broad-spectrum to narrow-spe...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Ethics in Surgical Education Research Michael M. Awad, Amy H. Kaji, Timothy M. Pawlik JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6705 Introduction Rigorous and well-designed research is integral to advance surgical education science. In contrast to clinical research in which study participants are patients, surgica...

ARTICLES|ONLINE FIRST Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial Yin Mo, Suchart Booraphun, Andrew Yunkai Li, et al Lancet Respir Med Published: January 22, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00418-6 Summary Background Ventilator-associated pneumonia (VAP) is associated with ...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Seven Myths of Mechanical Ventilation in Paediatric and Neonatal Patients In this article, we will examine clinical concepts that have persisted over time, despite advancements in our understanding of physiology and technological innovations that have demonstrated their inapplicability in the routine clinical care of paediatric patients requiring respiratory support. These enduring beliefs have effectivel...

Research Letter  December 28, 2023 Lifting of Embargoes to Data Sharing in Clinical Trials Published in Top Medical Journals Maximilian Siebert, John P. A. Ioannidis JAMA. 2024;331(4):354-355. doi:10.1001/jama.2023.25394 Data sharing in clinical trials enhances trust and reproducibility and allows secondary analyses.1 However, sharing of clinical trials data is the exception rather than the rule2 and is often limited by embargoes, which const...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Education Program Evaluation Research Marc de Moya, Jason S. Haukoos, Kamal M. F. Itani JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6702 Introduction Program evaluation is the systematic assessment of a program’s implementation. In medical education, evaluation includes the synthesis and analysis of educational prog...

ARTICLES|ONLINE FIRST Risk factors for COVID-19-associated pulmonary aspergillosis: a systematic review and meta-analysis Francesca Gioia, Laura N Walti, Ani Orchanian-Cheff, et al Lancet Published: January 04, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00408-3 Summary Background COVID-19-associated pulmonary aspergillosis (CAPA) has been reported to be an emerging and potentially fatal complication of severe COVID-19. However, risk factors for C...

Artificial Intelligence and the Future of Publishing Artificial intelligence (AI) can revolutionise medical publishing. The advantages of AI can be observed in three key areas: content, peer review, and post-publication. AI can enhance each process's speed, accuracy, and efficiency. AI can streamline content creation. It can assist researchers in analysing vast amounts of data, extracting relevant information, and synthesising it into comprehensive manuscri...

COMMENT|ONLINE FIRST The efficiency of computerised clinical decision support systems Andre Carlos Kajdacsy-Balla Amaral, Brian H Cuthbertson Lancet Published: January 20, 2024 DOI: https://doi.org/10.1016/S0140-6736(23)02839-8 The rapid increase in the uptake of electronic medical records over the past decade is leading to an increased deployment of computerised clinical decision support systems (CDSSs). These range from simple pop-up a...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Curricular Development Research Kevin Y. Pei, Todd A. Schwartz, Marja A. Boermeester JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6699 Introduction There has been a significant uptick of interest in curricular development, with more than 2500 publications in the last decade devoted to this area of health care educati...