IMMUNOCITRE Trial - Enteral L-citrulline Administration vs Placebo Critically ill patients admitted to the ICU often experience temporary immune deficiencies, leading to persistent organ dysfunction and a higher risk of ICU-acquired infections. Researchers have been exploring immune-enhancing diets to address these issues, focusing on nutrients like L-arginine. L-arginine is important because it can become deficient in critically ill patients and is associated with...

CDC updates and simplifies respiratory virus recommendations Recommendations are easier to follow and help protect those most at risk CDC released today updated recommendations for how people can protect themselves and their communities from respiratory viruses, including COVID-19. The new guidance brings a unified approach to addressing risks from a range of common respiratory viral illnesses, such as COVID-19, flu, and RSV, which can cause significant he...

Original Investigation  Pediatrics February 2, 2024 Whole-Blood Gene Expression Profile After Hypoxic-Ischemic Encephalopathy Paolo Montaldo, Constance Burgod, Jethro A. Herberg, et al JAMA Netw Open. 2024;7(2):e2354433. doi:10.1001/jamanetworkopen.2023.54433 Key Points Question  Do genome expression profiles at birth in neonates with hypoxic-ischemic encephalopathy (HIE) in a high-income country (HIC) differ from those of the...

Knowledge and Awareness of Sepsis Among Risk Populations Sepsis can have potentially life-threatening consequences. Early recognition is crucial for effective intervention. The role of patients in preventing and identifying sepsis early is vital. However, there is an incomplete understanding of sepsis knowledge among at-risk groups and their ability to recognise sepsis as a medical emergency. COVID-19 often leads to sepsis, with about one-third of hospitalised C...

Original Investigation  Infectious Diseases March 13, 2024 COVID-19 Rebound After VV116 vs Nirmatrelvir-Ritonavir Treatment: A Randomized Clinical Trial Zhitao Yang, Yu Xu, Ruizhi Zheng, et al JAMA Netw Open. 2024;7(3):e241765. doi:10.1001/jamanetworkopen.2024.1765 Key Points Question  How common is COVID-19 rebound after a standard 5-day course of treatment with VV116 vs nirmatrelvir-ritonavir? Findings  In this ...

Invited Commentary  January 31, 2024 Time to First Whole Blood Associated With Survival—First (Whole) Blood? Jason L. Sperry, Matthew D. Neal JAMA Surg. Published online January 31, 2024. doi:10.1001/jamasurg.2023.7186 Despite significant advances in resuscitation and management over time, mortality from traumatic injury continues to occur early, commonly within hours of arrival to definitive trauma care.1,2 Literature consistently has d...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Mechanical Power for Protective Mechanical Ventilation in Patients With and Without ARDS Mechanical power is an easy bedside tool to guide lung protective ventilation, as it is an index of the energy load applied to the lung during mechanical ventilation and expresses in one formula all the main determinants of ventilator-induced lung injury. Although a threshold value has not already been defined, a mech...

Original Investigation  Public Health January 30, 2024 A Smartphone-Based Shopping Mall Walking Program and Daily Walking Steps Yoko Matsuoka, Hiroaki Yoshida, Masamichi Hanazato JAMA Netw Open. 2024;7(1):e2353957. doi:10.1001/jamanetworkopen.2023.53957 Key Points Question  Can participating in a smartphone-based shopping mall walking program increase individuals’ daily step count? Findings  In this nationwide coh...

Original Investigation  Critical Care Medicine January 30, 2024 Mobile Critical Care Recovery Program for Survivors of Acute Respiratory Failure: A Randomized Clinical Trial Babar A. Khan, Anthony J. Perkins, Sikandar Hayat Khan, et al JAMA Netw Open. 2024;7(1):e2353158. doi:10.1001/jamanetworkopen.2023.53158 Key Points Question  Does an intensive care unit (ICU) recovery program comprising a nurse care coordinator supporte...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalPrediction of post-traumatic stress disorder in family members of ICU patients: a machine learning approachDupont T. et al. EditorialBalanced solution versus saline in critically ill patients: a new piece to the puzzle!Klouche K., Monnet X. and Zarbock A. Selective digestive decontamination: We must make an international decision on this 40-year old controversyCarlet J. Selective decontamination of the dige...