Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Pragmatic Clinical Trials in Surgical Education Research Karl Y. Bilimoria, Jason S. Haukoos, Gerard M. Doherty JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6690 Introduction In 1967, Schwartz and Lellouch1 distinguished “explanatory” trials from “pragmatic” trials by the nature of study intent: clinical trials ...

ORIGINAL ARTICLE Biomarker Changes during 20 Years Preceding Alzheimer’s Disease Jianping Jia, Yuye Ning, Meilin Chen, et al N Engl J Med 2024; 390:712-722DOI: 10.1056/NEJMoa2310168 Abstract BACKGROUND Biomarker changes that occur in the period between normal cognition and the diagnosis of sporadic Alzheimer’s disease have not been extensively investigated in longitudinal studies. METHODS We conducted a multicenter, nested case–control study of Alz...

ARTICLES| VOLUME 22, ISSUE 12, P1140-1149, DECEMBER 2023Download Full Issue Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials Rustam Al-Shahi Salman, Jacqueline Stephen, Prof Jayne F Tierney, et al. Lancet Neuron 2023; 22: 1140-1149 Published:October 12, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00315-0 Summar...

Original Investigation  November 29, 2023 Scalability and Sustainability of a Surgical Infection Prevention Program in Low-Income Environments Nichole Starr, Natnael Gebeyehu, Maia R. Nofal, et al JAMA Surg. Published online November 29, 2023. doi:10.1001/jamasurg.2023.6033 Key Points Question  Is a quality improvement program to reduce surgical site infections in low-income settings, modified t...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Machine Learning and Artificial Intelligence in Surgical Education Research Daniel A. Hashimoto, Julian Varas, Todd A. Schwartz JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6687 Introduction Artificial intelligence (AI) is the study of machine intelligence as it relates to perceiving and inferring data, typically wit...

ARTICLES|ONLINE FIRST Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales The HDR UK COALESCE Consortium Lancet Published:January 15, 2024 DOI:https://doi.org/10.1016/S0140-6736(23)02467-4 Summary Background Undervaccination (receiving fewer than the recommended number of SARS-CoV-2 vaccine doses) could be associated with increased risk of severe COVID-19 outcomes—ie...

ORIGINAL ARTICLE CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up Fabian Müller, Jule Taubmann, Laura Bucci, et al N Engl J Med 2024; 390:687-700DOI: 10.1056/NEJMoa2308917 Abstract BACKGROUND Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these diseases through ...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Surgical Simulation Research Aimee K. Gardner, Amy H. Kaji, Marja Boermeester JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6684 Introduction Simulation has become a crucial component of surgical education and practice. Not only has simulation been widely integrated into surgical training curricula,1,2 but the im...

Invited Commentary  January 8, 2024 Increasing Clinical Complexity—Implications for Care Delivery, Payment Models, and the Health Care Workforce Daniel M. Blumenthal JAMA Intern Med. Published online January 8, 2024. doi:10.1001/jamainternmed.2023.7407 In JAMA Internal Medicine, Naik et al1 present the results of a population-based serial, cross-sectional evaluation of trends in the complexity of hospitalized inpatients in British C...

Research Letter  Health Care Reform August 28, 2023 Career Plans of Internal Medicine Residents From 2019 to 2021 Neha Paralkar, Nancy LaVine, Saoirse Ryan, et al JAMA Intern Med. 2023;183(10):1166-1167. doi:10.1001/jamainternmed.2023.2873 Shortages of primary care clinicians are projected by numerous groups; the Association of American Medical Colleges projects a shortage of up to 48 000 primary care physicians by 2032.1 As internal medicine (...