Research Added benefit and revenues of oncology drugs approved by the European Medicines Agency between 1995 and 2020: retrospective cohort study Francine Brinkhuis, Wim G Goettsch, Aukje K Mantel-Teeuwisse, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077391 (Published 28 February 2024)Cite this as: BMJ 2024;384:e077391 Abstract Objectives To evaluate the added benefit and revenues of oncology drugs, explore their association, and investi...

Research Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses Melissa M Lane, Elizabeth Gamage, Shutong Du, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077310 (Published 28 February 2024)Cite this as: BMJ 2024;384:e077310 Abstract Objective To evaluate the existing meta-analytic evidence of associations between exposure to ultra-processed foods, as defined by the Nova food classificat...

Original Investigation  January 29, 2024 Efficacy of Electronic Cigarettes vs Varenicline and Nicotine Chewing Gum as an Aid to Stop Smoking: A Randomized Clinical Trial Hao-Xiang Lin, Zhao Liu, Peter Hajek, et al JAMA Intern Med. 2024;184(3):291-299. doi:10.1001/jamainternmed.2023.7846 Key Points Question  How do electronic cigarettes (ECs) as a stop-smoking aid compare with efficacy of varenicline and nicotine chewing gum? Findings&nb...

ORIGINAL ARTICLE Cognition and Memory after Covid-19 in a Large Community Sample Adam Hampshire, Adriana Azor, Christina Atchison, et al N Engl J Med 2024; 390:806-818DOI: 10.1056/NEJMoa2311330 Abstract BACKGROUND Cognitive symptoms after coronavirus disease 2019 (Covid-19), the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are well-recognized. Whether objectively measurable cognitive deficits exist and how long they per...

Environmental Sustainability and Antimicrobials Healthcare's environmental sustainability has become a pressing concern, with hospitals, clinical services, and the pharmaceutical industry identified as key contributors to environmental impact. Hospitals, in particular, are responsible for most greenhouse gas emissions, with the ICU being a significant consumer of resources like electricity, disposables, and pharmaceuticals. While most studies concentrate on these b...

ARTICLES|ONLINE FIRST Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults NCD Risk Factor Collaboration (NCD-RisC) Lancet Published:February 29, 2024 DOI: https://doi.org/10.1016/S0140-6736(23)02750-2 Summary Background Underweight and obesity are associated with adverse health outcomes throughout the life course. We estimated the ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalEffect of aggressive vs conservative screening and confirmatory test on time to extubation among patients at low or intermediate risk: a randomized clinical trialHernández Martínez G. et al Age and associated outcomes among patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory failure: analysis of the Extracorporeal Life Support Organization registryFernando S. M. et al OPEN A...

Research Letter  February 28, 2024 Nationwide Propensity-Matched Comparison of Surgical Site Infections in Safety Net Hospitals Lisa Ngo, Luis Quintero, Joshua P. Parreco JAMA Surg. Published online February 28, 2024. doi:10.1001/jamasurg.2023.7863 Since 2014, the Centers for Medicare and Medicaid Services (CMS) has been imposing financial penalties on hospitals with high rates of health care–associated infections and financially rewarding ho...

Acute Mesenteric Ischaemia: Incidence, Diagnosis, Management, Outcomes Acute mesenteric ischaemia (AMI) is a rare condition with challenging diagnosis due to nonspecific symptoms and lack of established diagnostic biomarkers. Existing evidence suggests high mortality rates with limited improvement in outcomes over time. Recent estimates indicate an incidence of approximately 5–7 cases per 10,000 hospital admissions, likely underestimated due to poor recognition. Di...

Research Optimal timing of influenza vaccination in young children: population based cohort study Christopher M Worsham, Charles F Bray, Anupam B Jena BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077076 (Published 21 February 2024)Cite this as: BMJ 2024;384:e077076 Abstract Objective To assess optimal timing of influenza vaccination in young children. Design Population based cohort study. Setting United States. Participants&nb...