ASTER Trial: Acetaminophen and Organ Dysfunction in Patients With Sepsis In Sepsis Wed, 22 May 2024 Acetaminophen (paracetamol) has several pharmacological effects that are potentially beneficial in sepsis, including analgesia, antipyresis, and cyclooxygenase-2 inhibition. Observational studies and small clinical trials suggest acetaminophen improves survival and kidney function in sepsis patients with elevated cell-free haemoglobin. However, a&nb...

COMMENT|ONLINE FIRST Global Burden of Disease Study 2021 estimates: implications for health policy and research Zachary J Ward, Sue J Goldie Lancet Published: April 17, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)00812-2 Over the past three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has produced several iterations of global estimates for various disease metrics.1 The latest iteration, GBD 2021, published in ...

ARTICLES| VOLUME 404, ISSUE 10453, P659-669, AUGUST 17, 2024 Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands Julia L M Bels, Steven Thiessen, Rob J J van Gassel, et al Lancet 2024; 404: 659-669 Published: August 17, 2024 DOI:https://doi.org/10.1016/S0140-6736(24)013...

ESICM/NACCS Recommendations: Targeted Temperature Control Following TBI In ICU Wed, 22 May 2024 Traumatic brain injury (TBI) is a highly prevalent global health issue, causing significant mortality and disability. It results from external forces affecting brain function or structure. TBI involves primary damage from the initial impact, followed by secondary injury processes such as ischaemia, swelling, and metabolic changes, which worsen outc...

Research Letter  Geriatrics June 11, 2024 Boarding Duration in the Emergency Department and Inpatient Delirium and Severe Agitation Joshua W. Joseph, Noémie Elhadad, Melissa L.P. Mattison, et al JAMA Netw Open. 2024;7(6):e2416343. doi:10.1001/jamanetworkopen.2024.16343 Introduction Recent studies have demonstrated that emergency department (ED) boarding (ie, holding admitted patients in the ED while...

Original Investigation  Diabetes and Endocrinology June 12, 2024 Limosilactobacillus reuteri 6475 and Prevention of Early Postmenopausal Bone Loss: A Randomized Clinical Trial Giulia Gregori, Aldina Pivodic, Per Magnusson, et al JAMA Netw Open. 2024;7(6):e2415455. doi:10.1001/jamanetworkopen.2024.15455 Key Points Question  Can daily supplementation with the probiotic Limosilactob...

Editorial  June 10, 2024 Anesthesia Dose and Delirium—A Picture Coming Into Focus Miles Berger, Mark D. Neuman JAMA. Published online June 10, 2024. doi:10.1001/jama.2023.26819 In this issue of JAMA,1 Deschamps and colleagues report results of the Electroencephalographic Guidance of Anesthesia to Alleviate Geriatric Syndromes-Canada (ENGAGES-Canada) trial. ENGAGES-Canada compared rates of postoperative delirium among 1140 patients 6...

Education and Clinical Practice: Original Research Creation and Validation of a Massive Hemoptysis Simulator Melissa L. New, Timothy Amass, Anna Neumeier, et al Chest 2024; 165: 636-644 https://doi.org/10.1016/j.chest.2023.10.014 Background Simulation for the management of massive hemoptysis is limited by the absence of a commercially available simulator to practice procedural skills necessary for management. Research Question Is it feasi...

Specialty Emergency Departments - The Future of Emergency Care? In ICU Tue, 14 May 2024 Specialised emergency departments (EDs) are emerging, focusing on specific patient populations such as oncologic, geriatric, or orthopaedic cases. Advocates argue that these specialised centres can provide more targeted and cost-effective care. They may alleviate pressure on general EDs while potentially improving overall...

Invited Commentary  February 21, 2024 Surgical Site Infections—Time to Test Cost-Effective Prevention Strategies? Jeffrey S. Upperman, Eunice Y. Huang JAMA Surg. 2024;159(5):492. doi:10.1001/jamasurg.2023.7979 The recent randomized clinical trial by Mueller et al1 assessing the effectiveness of polyhexanide 0.04% solution in surgical site infection (SSI) prevention following laparotomy presents findings that challenge established clinical pract...