ORIGINAL ARTICLE Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy Martin S. Maron, Ahmad Masri, Michael E. Nassif, et al N Engl J Med 2024;390:1849-1861 DOI: 10.1056/NEJMoa2401424 Abstract BACKGROUND One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction. ...

Original Investigation  Health Informatics March 20, 2024 Artificial Intelligence–Generated Draft Replies to Patient Inbox Messages Patricia Garcia, Stephen P. Ma, Shreya Shah, et al JAMA Netw Open. 2024;7(3):e243201. doi:10.1001/jamanetworkopen.2024.3201 Key Points Question  What is the adoption of and clinician experience with clinical practice deployment of a large language model used to draft responses to patient inbox mes...

Violence Against Healthcare Professionals in ICUs In ICU Tue, 5 Mar 2024 A new study reviewed existing literature on workplace violence (WPV) against healthcare workers (HCWs) in ICUs, focusing on prevalence, risk factors, interventions, and preventive measures. WPV, defined as violent acts or threats directed towards individuals at work, is a significant issue globally, with HCWs experiencing a 20% higher rate compared to other employees. However, WPV...

Practice Guidelines Suspected acute respiratory infection in over 16s: assessment at first presentation and initial management—summary of NICE guidance Chris Carmona, Tom Bewick, Nichola Macduff, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj.q339 (Published 11 March 2024)Cite this as: BMJ 2024;384:q339 What you need to know For patients with acute respiratory infection who can be cared for at home, ensure they understand signs of deterioration ...

Sex Differences in Vital Organ Support in ICU There is increasing evidence that factors such as sex, race, and socioeconomic status may influence the treatment received in ICUs. Data suggests that women are less likely to receive invasive ventilation, vasoactive medication, renal replacement therapy (RRT), extracorporeal membrane oxygenation (ECMO), and tracheostomy than men, but previous studies have shown heterogeneity and risk of bias. Factors like illness sever...

Research Derivation and external validation of a simple risk score for predicting severe acute kidney injury after intravenous cisplatin: cohort study Shruti Gupta, Ilya G Glezerman, Jamie S Hirsch, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077169 (Published 27 March 2024)Cite this as: BMJ 2024;384:e077169 Abstract Objective To develop and externally validate a prediction model for severe cisplatin associated acute kidney injury (CP-AKI...

Research Delirium and incident dementia in hospital patients in New South Wales, Australia: retrospective cohort study Emily H Gordon, David D Ward, Hao Xiong, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-077634 (Published 27 March 2024)Cite this as: BMJ 2024;384:e077634 Abstract Objectives To determine the strength and nature of the association between delirium and incident dementia in a population of older adult patients without dementia...

Editorial  April 1, 2024 Controlling Multidrug-Resistant Organisms Across Patient-Sharing Networks Christopher J. Crnich JAMA. Published online April 1, 2024. doi:10.1001/jama.2024.0267 Antimicrobial resistance is a major public health problem that threatens to reverse many of the medical therapy advances achieved over the past 4 decades.1 Infections caused by multidrug-resistant organisms (MDROs) are estimated to cause 35000 deaths in t...

Original Investigation  Hematology March 26, 2024 Accuracy of Diagnosing Heparin-Induced Thrombocytopenia Emil List Larsen, Henning Nilius, Jan-Dirk Studt, et al JAMA Netw Open. 2024;7(3):e243786. doi:10.1001/jamanetworkopen.2024.3786 Key Points Question  Is the current diagnostic practice for suspected heparin-induced thrombocytopenia (HIT) accurate? Findings  In this diagnostic study of 1318 patients suspected o...

Scientists Discover First New Antibiotic in Six Decades A ground-breaking class of antibiotics targeting drug-resistant Staphylococcus aureus (MRSA) bacteria has been discovered by applying transparent deep-learning models in medicine. Artificial intelligence (AI) is revolutionising the field, aiding scientists in unveiling the first novel antibiotics in six decades. Designated a priority-one critical pathogen by the World Health Organization, this organism has ...