Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial Voiriot, G., Argaud, L., Cohen, Y. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08014-9 Abstract Purpose Multiplex polymerase chain reaction (mPCR) testing has the potential to rapidly and accurately identify causative microorganisms in patients wi...

Mechanical Power in ARDS: Hand in Hand With Gattinoni ICU Management & Practice, Volume 25 - Issue 2, 2025 PRINT OPTIMISED SCREEN OPTIMISED High levels of mechanical power are associated with a higher incidence of lung damage and worse outcomes in patients with Acute Respiratory Distress Syndrome. This article explores the fundamentals of mechanical power, proper regulation of ventilatory support and the prevention of lung damage associated with mecha...

Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial Ke, L., Li, G., Mao, W. et al. Intensive Care Med (2025). https://doi.org/10.1007/s00134-025-08020-x Abstract Purpose Acute necrotic collection (ANC) is an early, local complication of necrotizing pancreatitis, and guidelines recommend a deliberate delay in treating ANC. In patients with ear...

Predicting Septic Shock Mortality in ICUs with AI  In Sepsis Sun, 4 May 2025 Septic shock, a severe manifestation of sepsis, poses a persistent threat to patients in intensive care units (ICUs), with its complex pathophysiology and high mortality rates making early intervention difficult. Previous machine learning models have attempted to predict sepsis outcomes but were limited by narrow patient scopes, insufficient validation, or low generalisab...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT OPEN ACCESS ~ What's New in Intensive Care Renal replacement therapyGaudry S., Srisawat N. & Joannidis M. LATEST ARTICLES Original Short- and long-term outcomes and 15-year time trends of kidney replacement therapy in critically ill patients with obesity: an observational cohortMonet C., Bouziane J., Pensier J., et al. Altered lower brainstem neurophysiological response is asso...

Original Investigation  Health Informatics Electronic Health Record Interventions to Reduce Risk of Hospital Readmissions: A Systematic Review and Meta-Analysis Badal S. B. Pattar, Abigail Ackroyd, Emir Sevinc, et al JAMA Netw Open 2025;8;(7):e2521785. doi:10.1001/jamanetworkopen.2025.21785 Key Points Question  Are electronic health record (EHR)–based interventions associated with reduced risk of hospital...

Less is More in Shock Management In ICU Tue, 6 May 2025 Permissive hypotension, phenotyping shock, vasopressor selection and timing, and emerging interest in beta-blockade for septic patients. It is important to reconsider conventional aggressive approaches to shock management and explore the evolving concept of permissive hypotension. There is a need to avoid reflexively treating all hypotension with vasopressors or fluids and instead focus on patient-...

Research Letter  Initial Antibiotic Selection Strategy and Subsequent Antibiotic Use—Insights From the INSPIRE Trials Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA Published Online: July 17, 2025 doi: 10.1001/jama.2025.11256 Four cluster-randomized trials have demonstrated that a stewardship bundle including real-time computerized provider order entry (CPOE) prompts safely reduced initial extend...

Critical Care: Research Letters Use of High-Dose Hydroxocobalamin for Septic Shock Jason R. Carr, Brian Locke, Jayshil J. Patel, et al Chest 2025; 168: 131-135 To the Editor: Septic shock, a global health burden with a case fatality rate exceeding 40%, is initiated and maintained by circulating nitric oxide and hydrogen sulfide that are emergent targets of therapeutic interest.1 High-dose (5-gm) hydroxocobalamin (vitamin B12) (HD-HOC) scavenges circula...

Original Investigation  Infectious Diseases Estimated Burden of Influenza and Direct and Indirect Benefits of Influenza Vaccination Mary G. Krauland, Alexis Mandell, Mark S. Roberts JAMA Netw Open 2025;8;(7):e2521324. doi:10.1001/jamanetworkopen.2025.21324 Key Points Question  What is the estimated influenza case burden, both direct and indirect, averted by vaccination? Findings  This decision ana...