Original Investigation  February 20, 2023 Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial Susanna Naggie, David R. Boulware, Christopher J. Lindsell, et al JAMA. Published online February 20, 2023. doi:10.1001/jama.2023.1650 Key Points Question  Does ivermectin, with a maximum targeted dose of 600 μg/kg daily for 6 days, compared with p...

Original Investigation  February 21, 2023 History of Low Hourly Wage and All-Cause Mortality Among Middle-aged Workers Katrina L. Kezios, Peiyi Lu, Sebastian Calonico, et al JAMA. 2023;329(7):561-573. doi:10.1001/jama.2023.0367 Key Points Question  Is a history of sustained low-wage earning during peak midlife earning years associated with elevated mortality risk and excess mortality? Findings  In a longitudinal stud...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalEffectiveness of an intensive care telehealth programme to improve process quality (ERIC): a multicentre stepped wedge cluster randomised controlled trialSpeis C.D. et al. OriginalsEpidemiology, clinical presentation, and outcomes of 620 patients with eosinophilia in the intensive care unitGaillet A., Bay P. and Groh M. Renal outcomes following intravenous contrast administration in patients with...

Barriers to Nurse-Led Pain Management in ICU Approximately 58% of patients in the ICU experience pain. Pain can lead to additional consequences, including delirium, decreased healing and adverse physiological and psychological outcomes. Hence, effective pain management is an integral component of a critical care nurse's role. Commonly used pain assessment tools depend on a patient's ability to communicate. ICU nurses must be capable of assessing pain using behav...

Original Investigation  February 21, 2023 Aspirin Discontinuation at 24 to 28 Weeks’ Gestation in Pregnancies at High Risk of Preterm Preeclampsia: A Randomized Clinical Trial Manel Mendoza, Erika Bonacina, Pablo Garcia-Manau, et al JAMA. 2023;329(7):542-550. doi:10.1001/jama.2023.0691 Key Points Question  Among individuals taking aspirin to prevent preterm preeclampsia, can aspirin be discontinued at 24 to 28 weeks of gestation ...

Research Health and nutrition claims for infant formula: international cross sectional survey Ka Yan Cheung, Loukia Petrou, Bartosz Helfer, et al BMJ 2023; 380 doi: https://doi.org/10.1136/bmj-2022-071075 (Published 15 February 2023)Cite this as: BMJ 2023;380:e071075 Abstract Objectives To review available health and nutrition claims for infant formula products in multiple countries and to evaluate the validity o...

Genome-Wide Association Study of Patients With Sepsis Sepsis is a systemic inflammatory response to infections accompanied by organ dysfunction. Sepsis has a high mortality rate of about 30%. Approximately 189 cases of sepsis per 100,000 people are reported per year. Many genetic studies have identified gene variants associated with the development and outcomes of sepsis.  In this study, the researchers conduct the first genome-wide association study of 28-...

Original Published: 10 February 2023 Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study Alexis Tabah, Niccolò Buetti, Quentin Staiquly, et al Intensive Care Med (2023). https://doi.org/10.1007/s00134-022-06944-2 Abstract Purpose In the critically ill, hospital-acquired bloodstream infections (HA-BSI) are associated with significant mortality. Granular ...

Original Investigation  Less Is More September 19, 2022 Perioperative Gabapentin Use and In-Hospital Adverse Clinical Events Among Older Adults After Major Surgery Chan Mi Park, Sharon K. Inouye, Edward R. Marcantonio, et al JAMA Intern Med. 2022;182(11):1117-1127. doi:10.1001/jamainternmed.2022.3680 Key Points Question  Is perioperative gabapentin use associated with in-hospital adverse clinical events among older adults after maj...

EDITORIAL Improved Prospects for Thrombectomy in Large Ischemic Stroke Pierre Fayad N Engl J Med February 10, 2023DOI: 10.1056/NEJMe2300193 Mechanical endovascular thrombectomy, when performed within 24 hours after the onset of symptoms in patients with small-to-moderate acute ischemic strokes that are due to proximal occlusion of a large cerebral vessel, has been shown to result in rates of recanalization of 70 to 80% and to significantly improve functional i...