Original Investigation  Hematology March 26, 2024 Accuracy of Diagnosing Heparin-Induced Thrombocytopenia Emil List Larsen, Henning Nilius, Jan-Dirk Studt, et al JAMA Netw Open. 2024;7(3):e243786. doi:10.1001/jamanetworkopen.2024.3786 Key Points Question  Is the current diagnostic practice for suspected heparin-induced thrombocytopenia (HIT) accurate? Findings  In this diagnostic study of 1318 patients suspected o...

Scientists Discover First New Antibiotic in Six Decades A ground-breaking class of antibiotics targeting drug-resistant Staphylococcus aureus (MRSA) bacteria has been discovered by applying transparent deep-learning models in medicine. Artificial intelligence (AI) is revolutionising the field, aiding scientists in unveiling the first novel antibiotics in six decades. Designated a priority-one critical pathogen by the World Health Organization, this organism has ...

Original Investigation  Infectious Diseases March 27, 2024 CDC’s Hospital-Onset Clostridioides difficile Prevention Framework in a Regional Hospital Network Nicholas A. Turner, Jay Krishnan, Alicia Nelson, et al JAMA Netw Open. 2024;7(3):e243846. doi:10.1001/jamanetworkopen.2024.3846 Key Points Question  Was implementation of the Centers for Disease Control and Prevention’s Strategies to Prevent Clostridioides d...

Original Investigation  April 1, 2024 Reducing Hospitalizations and Multidrug-Resistant Organisms via Regional Decolonization in Hospitals and Nursing Homes Gabrielle M. Gussin, James A. McKinnell, Raveena D. Singh, et al JAMA. Published online April 1, 2024. doi:10.1001/jama.2024.2759 Key Points Question  Is implementation of a regional hospital and nursing home decolonization collaborative (coordinated intervention adopted by p...

Computerised Decision Support Alerts for High-Risk Drug Combinations Existing clinical decision support systems (CDSSs) designed to prevent drug-drug interaction (DDI) often generate low-yield alerts, leading to alert fatigue among physicians and jeopardising patient safety.  A recent study focuses on the impact of tailoring DDI alerts to the ICU setting to reduce the frequency of high-risk drug combinations. The multicentre study aims to assess how customising...

Original Investigation  March 18, 2024 Text vs Patient Portal Messaging to Improve Influenza Vaccination Coverage: A Health System–Wide Randomized Clinical Trial Peter G. Szilagyi, O. Kenrik Duru, Alejandra Casillas, et al JAMA Intern Med. Published online March 18, 2024. doi:10.1001/jamainternmed.2024.0001 Key Points Question  Can either patient portal or text message reminders to patients abou...

Research Letter  March 25, 2024 Fatal Traffic Risks With a Total Solar Eclipse in the US Donald A. Redelmeier, John A. Staples JAMA Intern Med. Published online March 25, 2024. doi:10.1001/jamainternmed.2023.5234 A total solar eclipse occurs when the moon temporarily obscures the sun and casts a dark shadow across the earth. This astronomical spectacle has been described for more than 3 millennia and can be predicted with ...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Conference Reports and Expert Panel - Co-publication with the ERJDyspnoea in acutely ill mechanically ventilated adult patients: an ERS/ESICM statementDemoule Al. et al OriginalRenal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trialRambaud T. et al Venoarterial extracorporeal membrane oxygenation in immunoco...

Leading health agencies outline updated terminology for pathogens that transmit through the air 18 April 2024  News release Following consultation with public health agencies and experts, the World Health Organization (WHO) publishes a global technical consultation report introducing updated terminology for pathogens that transmit through the air. The pathogens covered include those that cause respiratory infections, e.g. COVID-19, influenza, measles, Middle...

Original Investigation  March 25, 2024 Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults Ashwin B. Gupta, Scott A. Flanders, Lindsay A. Petty, et al JAMA Intern Med. Published online March 25, 2024. doi:10.1001/jamainternmed.2024.0077 Key Points Question  In hospitalized patients diagnosed with pneumonia, what is the incidence of and factors associated with inappropriate diagnosis? ...