Original Investigation  April 15, 2024 Acute Cardiac Events in Hospitalized Older Adults With Respiratory Syncytial Virus Infection Rebecca C. Woodruff, Michael Melgar, Huong Pham, et al JAMA Intern Med. 2024;184(6):602-611. doi:10.1001/jamainternmed.2024.0212 Key Points Question  What are the frequency and severity of acute cardiac events among hospitalized adults aged 50 years or older with laboratory-c...

SOUNDING BOARD FROM THE NATIONAL ACADEMY OF MEDICINE Long Covid Defined E. Wesley Ely, Lisa M. Brown, Harvey V. Fineberg., for the National Academies of Sciences, Engineering, and Medicine Committee on Examining the Working Definition for Long Covid N Engl J Med Published July 31, 2024 DOI: 10.1056/NEJMsb2408466 The Covid-19 pandemic has been perceived mainly as a dangerous acute outbreak of infection that killed more ...

Original Investigation  June 7, 2024 Nirmatrelvir-Ritonavir and Symptoms in Adults With Postacute Sequelae of SARS-CoV-2 Infection: The STOP-PASC Randomized Clinical Trial Linda N. Geng, Hector Bonilla, Haley Hedlin, et al JAMA Intern Med. Published online June 7, 2024. doi:10.1001/jamainternmed.2024.2007 Key Points Question  What is the efficacy of 15 days of nirmatrelvir-ritonavir for improvin...

US Preventive Services Task Force  Recommendation Statement June 4, 2024 Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement US Preventive Services Task Force JAMA. 2024;332(1):51-57. doi:10.1001/jama.2024.8481 Abstract Importance  Falls are the leading cause of injury-related morbidity and mortality among older adults in the US. In 2018, 27.5% of com...

Invited Commentary  Pediatrics June 5, 2024 The Quest for Evidence on Time to Antibiotics in Children With Sepsis—Finding the Sweet Spot Nora Luethi, Luregn J. Schlapbach, Philipp Baumann JAMA Netw Open. 2024;7(6):e2413926. doi:10.1001/jamanetworkopen.2024.13926 Timely recognition and management of sepsis in children remains a major challenge in pediatric emergency care, where most patients with sepsis present. Avoiding delays in antimicro...

Adaptive Platform Trials in Critical Care In ICU Tue, 5 Mar 2024 Over the last fifty years, randomised clinical trials have advanced medical practice, particularly in critical care. These trials offer the most rigorous means of determining treatment effects, allowing for evaluating new and established medical interventions within ICUs. Despite their profound impact, clinical trials are challenging endeavours. They are costly, time-consuming, and com...

Original Investigation  Nutrition, Obesity, and Exercise June 5, 2024 Body Roundness Index and All-Cause Mortality Among US Adults Xiaoqian Zhang, Ning Ma, Qiushi Lin, et al JAMA Netw Open. 2024;7(6):e2415051. doi:10.1001/jamanetworkopen.2024.15051 Key Points Question  What are the temporal trends of body roundness index (BRI) and its association with all-cause mortality among US adults? F...

Viewpoint  June 5, 2024 Failure to Rescue as a Quality Measure in Sepsis Stephanie Parks Taylor, Marc Kowalkowski JAMA. Published online June 5, 2024. doi:10.1001/jama.2024.6771 Successful initiatives like the Surviving Sepsis Campaign, with a focus on early diagnosis and treatment, have resulted in significant improvements in mortality for patients with sepsis. However, sepsis remains the leading cause of death and disability, present in 53%...

ARTICLES|ONLINE FIRST Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial Matthew F Mart, Leanne M Boehm, Amy L Kiehl, et al Lancet Respire Med Published:April 30, 2024 DOI:https://doi.org/10.1016/S2213-2600(24)00077-8 Summary Background Delirium is common during critical illness and is associated with long-term cognitive impairment and disability. Antip...

Original Investigation  Pediatrics June 5, 2024 Delays to Antibiotics in the Emergency Department and Risk of Mortality in Children With Sepsis Roni D. Lane, Troy Richardson, Halden F. Scott, et al JAMA Netw Open. 2024;7(6):e2413955. doi:10.1001/jamanetworkopen.2024.13955 Key Points Question  Is the timing of antibiotic administration associated with sepsis-attributable mortality in pediatric...