Original Investigation  Emergency Medicine In-Flight Medical Events on Commercial Airline Flights Paulo M. Alves, Karan R. Kumar, Justin Devlin, et al JAMA Netw Open 2025;8;(9):e2533934. doi:10.1001/jamanetworkopen.2025.33934 Key Points Question  What are the characteristics of in-flight medical events on commercial airline flights and the factors associated with aircraft diversion, hospital transport, an...

Multimodal CT Predicts AKI Risk in Pneumonia Sepsis  In Imaging Wed, 1 Oct 2025 Sepsis frequently results in acute kidney injury, prolonging hospital stay and increasing mortality risk. Incidence estimates range from 35–50% in sepsis and rise to 50–70% in intensive care. Early prediction remains difficult because current approaches rely on blood and urine tests that can be costly, variable and not always available in time for intervention. Pneumon...

Research Letter  Pacific Coast Surgical Association Hospital Market Competition, Morbidity, and Resource Utilization Following Elective Cancer Resection Sara Sakowitz, Syed Shahyan Bakhtiyar, Nicholas S. Siena, et al JAMA Surg Published Online: October 1, 2025 doi: 10.1001/jamasurg.2025.3643 Over the past decade, health system mergers and expansions, along with evidence supporting the volume-outcome relat...

Optimal Partial Oxygen Pressure in Patients Receiving Mechanical Ventilation In ICU Thu, 2 Oct 2025 Mechanical ventilation is an intervention used worldwide in intensive care, with most patients also receiving supplemental oxygen. Determining the optimal arterial oxygen target (PaO₂) is essential, as both hypoxaemia and hyperoxaemia carry risks.  A recent review examines these risks and provides evidence-based guidance on appropriate oxygen tar...

Original Investigation  Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: The Budesonide in Babies (BiB) Randomized Clinical Trial Namasivayam Ambalavanan, Waldemar A. Carlo, Kayla J. Nowak, et al JAMA Published Online: September 30, 2025 doi: 10.1001/jama.2025.16450 Key Points Question  Does intratracheal administration of budesonide mixed with su...

Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases Monneret G, Lafon T, Gossez M, et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08110-w Abstract Purpose Septic patients simultaneously experience hyperinflammation and immunosuppression, the latter driving ICU-acquired infections, prolonged stays in ICU, and increased mortality. As immunostimulant therapies enter clinical trials, ...

Editorial  AI in Medicine Artificial Intelligence and Diabetes Prevention Leigh Perreault JAMA Published Online: October 27, 2025 doi: 10.1001/jama.2025.20099 As of 2021, an estimated 38.4 million people in the US had diabetes, and 97.6 million with prediabetes were at increased risk of diabetes.1 Approximately 70% of people with prediabetes develop diabetes over their lifetime.2,3 Furthermore, there is evidence that people with prediabetes have inc...

European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care Jerry P. Nolan, Claudio Sandroni, Alain Cariou, et al Intensive Care Med (2025) https://doi.org/10.1007/s00134-025-08117-3 Abstract The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the Int...

Large Language Models in Clinical Reasoning In ICU Thu, 2 Oct 2025 Large language models (LLMs) are increasingly used in clinical care for documentation, communication, and decision support, but their reasoning abilities remain difficult to evaluate. Traditional benchmarks, though useful, often measure knowledge recall rather than true clinical reasoning. Script Concordance Testing (SCT) offers a scalable way to assess a core skill: adjusting diagno...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT What's New in Intensive Care Short piece: metabolic acidosisJung, B., Forni, L.G. & Jaber, S. Narrative Review Bedside thoracic echography in ICU: new insights for acute circulatory and respiratory failureMuller, L., Volpicelli, G., Mongodi, S. et al. Editorial Best practices in airway management in critically ill adultsDe Jong, A., Jaber, S. & Myatra, S.N. LATEST ARTICL...