Reducing Diagnostic Errors in Critical Illness  In ICU Fri, 31 Oct 2025 Accurate diagnosis underpins safe and effective critical care, yet the diagnostic process in acute illness is inherently vulnerable. Time pressure, evolving physiology and limited patient history often converge when illness is most severe. Critical illness is also encountered beyond intensive care units (ICUs) and in some cases follows earlier diagnostic missteps that escalate...

Original Investigation  Health Informatics Large Language Model Performance and Clinical Reasoning Tasks Arya S. Rao, Kaiz P. Esmail, Richard S. Lee, et al JAMA Netw Open 2026;9;(4):e264003. doi:10.1001/jamanetworkopen.2026.4003 Key Points Question  Can off-the-shelf large language models (LLMs) demonstrate reliable performance across the clinical workflow? Findings  In this cross-sectional s...

Original Investigation  Pediatrics Changes in Academic Standardized Testing After Pediatric Intensive Care Claire C. Foster, Melanie Boyd, Erin F. Carlton, et al JAMA Netw Open 2026;9;(4):e269948. doi:10.1001/jamanetworkopen.2026.9948 Key Points Question  Is pediatric intensive care unit (PICU) admission associated with a decrease in academic achievement assessment scores? Findings  In this c...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Prophylactic noninvasive ventilation after extubation in high-risk patients without hypercapniaThille, A.W., Chamblet, L., Ragot, S. et al. OPEN ACCESS ~ Imaging in Intensive Care Medicine Demonstration of the acute hemodynamic effects of dynamic left ventricular outflow obstructionYao, R.J.R., Jiang, M., Lee, R. et al. OPEN ACCESS ~ Narrative Review Mechanical ventilation for ICU patient w...

Optimal Timing of Anticoagulation After Ischaemic Stroke and Atrial Fibrillation In ICU Wed, 25 Jun 2025 Atrial fibrillation (AF) accounts for about 20–30% of ischaemic strokes. Direct oral anticoagulants (DOACs) are very effective for long-term secondary prevention of ischaemic stroke in AF patients, reducing the risk of intracranial haemorrhage by about half compared to vitamin K antagonists. However, the best timing to start anticoagulation after an...

Articles Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Meningitis & Antimicrobial Resistance Collaborators Summary Background Meningitis remains the leading infectious cause of neurological disabilities globally, disproportionately affecting children younger than 5 years and populations in the African meningitis belt. Whereas p...

Articles Efficacy and safety of cemdisiran siRNA in myasthenia gravis (NIMBLE): a double-blind, randomised, placebo-controlled, phase 3 trial Tuan Vu, Ali A Habib, Saiju Jacob, et al Lancet 2026; 407: 1712-1725 https://doi.org/10.1016/S0140-6736(26)00690-2 Summary Background Autoantibody-mediated complement activation drives pathology in acetylcholine receptor (AChR) antibody-positive generalised myasthenia gravis. Newer targeted therapies lower overa...

Viewpoint  AI in Medicine Artificial Intelligence Is Not the End of the Physician Canio Martinelli, Vincenzo Carnevale, Alfredo Ercoli, et al JAMA Published Online: April 29, 2026 doi: 10.1001/jama.2026.4356 No one predicted that artificial intelligence (AI) would first surpass physicians on empathy—diagnostic accuracy, perhaps; imaging interpretation, certainly. Empathy was supposed to be the last refuge...

#LIVES2025: Proactive vs Reactive Treatment of Hypotension During Surgery  In ICU Tue, 28 Oct 2025 Intraoperative hypotension affects over 75% of surgical patients and is linked to serious complications, including myocardial ischaemia, kidney failure, and death. Despite this prevalence, uncertainty remains about optimal blood pressure management during surgery.  The PRETREAT (Proactive vs Reactive Treatment of Hypo...

Original Investigation  MySurgeryRisk Model Predictions of Postoperative Complications and Mortality Yuanfang Ren, Esra Adiyeke, Ziyuan Guan, et al JAMA Surg Published Online: April 29, 2026 doi: 10.1001/jamasurg.2026.1112 Key Points Question  Will applying the MySurgeryRisk framework, originally developed and prospectively validated on a single-center dataset, to a large multicenter dataset enh...