Editorial  June 10, 2024 Anesthesia Dose and Delirium—A Picture Coming Into Focus Miles Berger, Mark D. Neuman JAMA. Published online June 10, 2024. doi:10.1001/jama.2023.26819 In this issue of JAMA,1 Deschamps and colleagues report results of the Electroencephalographic Guidance of Anesthesia to Alleviate Geriatric Syndromes-Canada (ENGAGES-Canada) trial. ENGAGES-Canada compared rates of postoperative delirium among 1140 patients 6...

Education and Clinical Practice: Original Research Creation and Validation of a Massive Hemoptysis Simulator Melissa L. New, Timothy Amass, Anna Neumeier, et al Chest 2024; 165: 636-644 https://doi.org/10.1016/j.chest.2023.10.014 Background Simulation for the management of massive hemoptysis is limited by the absence of a commercially available simulator to practice procedural skills necessary for management. Research Question Is it feasi...

Specialty Emergency Departments - The Future of Emergency Care? In ICU Tue, 14 May 2024 Specialised emergency departments (EDs) are emerging, focusing on specific patient populations such as oncologic, geriatric, or orthopaedic cases. Advocates argue that these specialised centres can provide more targeted and cost-effective care. They may alleviate pressure on general EDs while potentially improving overall...

Invited Commentary  February 21, 2024 Surgical Site Infections—Time to Test Cost-Effective Prevention Strategies? Jeffrey S. Upperman, Eunice Y. Huang JAMA Surg. 2024;159(5):492. doi:10.1001/jamasurg.2023.7979 The recent randomized clinical trial by Mueller et al1 assessing the effectiveness of polyhexanide 0.04% solution in surgical site infection (SSI) prevention following laparotomy presents findings that challenge established clinical pract...

ARTICLES|ONLINE FIRST Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Causes of Death Collaborators Lancet Open Access Published: April 03, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)00367-2 Summary Background Regular, detailed reporting on population health by underlying caus...

Past, Present, and Future of Sustainable Intensive Care In ICU Tue, 14 May 2024 Climate change is a critical challenge of the 21st century, with fossil fuel combustion being the largest contributor, responsible for over 75% of greenhouse gas (GHG) emissions. The global healthcare industry significantly impacts the environment, accounting for up to 5% of global carbon emissions, with the U.S. contributing the largest share. Nations with high c...

ARTICLES|ONLINE FIRST Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 GBD 2021 Diseases and Injuries Collaborators Lancet Open Access Published: April 17, 2024 DOI: https://doi.org/10.1016/S0140-6736(...

Invited Commentary  June 5, 2024 Travel Guide From the Brave New World of Artificial Intelligence Daniel E. Hall JAMA Surg. Published online June 5, 2024. doi:10.1001/jamasurg.2024.1645 Just over 1 year has passed since ChatGPT (OpenAI) burst onto the scene to become the fastest growing consumer software application in history.1 It was immediately obvious that large language models (LLMs) were extraordinarily powerful, but the scope, nat...

Research Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study Ping Liu, Simon Sawhney, Uffe Heide-Jørgensen, et al BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-078063 (Published 15 April 2024)Cite this as: BMJ 2024;385:e078063 Abstract Objective To train and test a super learner strategy for ri...

Corticosteroids in Critically Ill Patients With Sepsis, ARDS and CAP In ICU Tue, 14 May 2024 Critical illness-related corticosteroid insufficiency (CIRCI) is commonly seen in criticall ill patients and involves systemic inflammation, hypothalamus–pituitary–adrenal axis dysregulation, altered cortisol metabolism, and tissue glucocorticoid resistance. A task force of international experts from the Society of Critical Care Medicine (SCCM) and the ...