Research Predicting the risks of kidney failure and death in adults with moderate to severe chronic kidney disease: multinational, longitudinal, population based, cohort study Ping Liu, Simon Sawhney, Uffe Heide-Jørgensen, et al BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-078063 (Published 15 April 2024)Cite this as: BMJ 2024;385:e078063 Abstract Objective To train and test a super learner strategy for ri...

Corticosteroids in Critically Ill Patients With Sepsis, ARDS and CAP In ICU Tue, 14 May 2024 Critical illness-related corticosteroid insufficiency (CIRCI) is commonly seen in criticall ill patients and involves systemic inflammation, hypothalamus–pituitary–adrenal axis dysregulation, altered cortisol metabolism, and tissue glucocorticoid resistance. A task force of international experts from the Society of Critical Care Medicine (SCCM) and the ...

Original Investigation  June 10, 2024 Electroencephalography-Guided Anesthesia and Delirium in Older Adults After Cardiac Surgery: The ENGAGES-Canada Randomized Clinical Trial Alain Deschamps, Arbi Ben Abdallah, Eric Jacobsohn, et al JAMA. Published online June 10, 2024. doi:10.1001/jama.2024.8144 Key Points Question  Does electroencephalography-guided anesthetic administration to minimize elect...

Editor's Note  June 3, 2024 Traditional Chinese Medicine to Prevent Type 2 Diabetes—A Difficult Path Forward Mitchell H. Katz JAMA Intern Med. Published online June 3, 2024. doi:10.1001/jamainternmed.2024.1208 Safe and effective treatments for preventing type 2 diabetes in persons at high risk for the disease are needed. In this issue of JAMA Internal Medicine, Ji and colleagues1 randomized patients with impaired glucose tolerance a...

Research Letter  February 21, 2024 Electric Bicycle Injuries and Hospitalizations Adrian M. Fernandez, Kevin D. Li, Hiren V. Patel, et al JAMA Surg. 2024;159(5):586-588. doi:10.1001/jamasurg.2023.7860 Electric bicycles (e-bicycles) are a popular consumer choice in the clean transportation revolution. Imports of e-bicycles topped 1.1 million in 2022 compared with 437 000 in 2020.1 We examined e-bicycle injuries and hospitalizations in the US fro...

Toward Greener Anaesthesia Practices: Mitigating the Environmental Impact In ICU Wed, 24 Apr 2024 Inhaled anaesthetics, including volatile hydrofluorocarbons like desflurane, sevoflurane, isoflurane, and halothane, as well as nitrous oxide (N2O), have potent greenhouse gas properties, contributing significantly to global warming and ozone layer depletion. Despite efforts to mitigate their release through gas scavenging systems, these gases are ultimate...

Original Investigation  February 21, 2024 Intraoperative Wound Irrigation for the Prevention of Surgical Site Infection After Laparotomy: A Randomized Clinical Trial by CHIR-Net Tara Catharina Mueller, Victoria Kehl, Rebekka Dimpel, et al JAMA Surg. 2024;159(5):484-492. doi:10.1001/jamasurg.2023.7985 Key Points Question  Is prophylactic intraoperative wound irrigation with polyhexanide 0.04% solution e...

Editor's Note  April 15, 2024 RSV Vaccination—The Juice Is Worth the Squeeze Tracy Y. Wang JAMA Intern Med. 2024;184(6):611. doi:10.1001/jamainternmed.2024.0219 In this issue of JAMA Internal Medicine, Woodruff et al1 present a cross-sectional study of patients 50 years and older who were hospitalized and tested positive for respiratory syncytial virus (RSV), reporting that 22% experienced an acute cardiac event, including acute exacerbation ...

Original Investigation  March 6, 2024 Robotic Technology in Emergency General Surgery Cases in the Era of Minimally Invasive Surgery Nicole Lunardi, Aida Abou-Zamzam, Katherine L. Florecki, et al JAMA Surg. 2024;159(5):493-499. doi:10.1001/jamasurg.2024.0016 Key Points Question  Do outcomes for emergency general surgery vary by surgical approach? Findings  In this cohort study of more than 1 ...

Antibiotic Overuse in Newborns With Suspected Sepsis In Sepsis Wed, 8 May 2024 A recent study conducted by the University of Gothenburg involving over a million newborns in Sweden highlights a concerning trend: despite a notable decrease in the rate of sepsis among this group, the administration of antibiotics remains disproportionately high. The study, published in JAMA, highlights the need for a reevaluation of antibiotic use practices in newbor...