Invited Commentary  Emergency Medicine Is Poor Recognition of Out-of-Hospital Cardiac Arrest to Blame for Worse Rates of Survival at Night? Sarah M. Perman JAMA Netw Open 2026;9;(4):e269837. doi:10.1001/jamanetworkopen.2026.9837 Emergency care is a 24 hours-a-day, 7 days-a-week, and 365 days-a-year operation. Those of us in emergency medicine, prehospital medicine, and acute critical care staff departments and agencies care for any patient with...

ORIGINAL ARTICLE Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention Divaka Perera, Matthew Ryan, Saad M. Ezad, et al N Engl J Med 2026;394:1779-1789 DOI: 10.1056/NEJMoa2515704 Abstract BACKGROUND Complex percutaneous coronary intervention (PCI) in patients with severely impaired left ventricular function carries a high risk of death and complications. Whether percutaneous left ventricular unlo...

Global Mortality Patterns Shift as COVID-19 Recedes  In ICU Mon, 3 Nov 2025 Regular, comparable assessments of causes of death help set health priorities. Updated estimates now cover 292 causes across 204 countries and territories, plus 660 subnational locations, for each year from 1990 to 2023. The analysis combines death counts, rates and years of life lost (YLLs) and adds two intuitive measures: the probability of dying before age 70 ...

Original Investigation  Caring for the Critically Ill Patient Prone Positioning in Infants With Acute Bronchiolitis: The PROPOSITIS Randomized Clinical Trial Florent Baudin, Robin Pouyau, Fabien Subtil, et al JAMA 2026;336;(4):315-322. doi:10.1001/jama.2026.11078 Key Points Question  Does prone positioning reduce escalation of respiratory support in infants aged 6 months or younger with moderate to severe bronchiolitis receiving high-flow ...

Original Investigation  Association of Rectal Cancer Accreditation with Patient Volume and Procedural Trends in the US Anthony Loria, Yusheng Jia, Ronald J. Weigel, et al JAMA Surg Published Online: May 6, 2026 doi: 10.1001/jamasurg.2026.1259 Key Points Question  Is National Accreditation Program for Rectal Cancer (NAPRC) accreditation associated with changes in rectal cancer patient volume, pro...

Comment Real-time subphenotyping in acute respiratory distress syndrome: a step towards precision medicine Denise Battaglini, Marcus J Schultz, Patricia R M Rocco The Lancet Respiratory Medicine, Available online 23 March 2026 https://doi.org/10.1016/S2213-2600(26)00054-8 Acute respiratory distress syndrome (ARDS) has long been defined by pragmatic clinical criteria that favour sensitivity over biological specificity. This strategy has enabled early recognitio...

Research Letter  Physician Work Environment and Well-Being Turnover and Burnout Among Family Physicians Dhruv Khullar, Lawrence P. Casalino, Richard G. Kronick, et al JAMA Intern Med 2026;186;(5):635-637. doi:10.1001/jamainternmed.2026.0271 Physician burnout may be associated with leaving practice or moving to a new practice, resulting in clinician shortages, especially in primary care.1 Evidence suggests that pa...

Original Investigation  Red Blood Cell Exchange Transfusion for Severe Babesiosis STOP-BABESIOSIS Investigators JAMA Intern Med 2026;186;(5):597-607. doi:10.1001/jamainternmed.2026.0244 Key Points Question  Is red blood cell exchange transfusion (ET) associated with improved clinical outcomes in patients hospitalized with severe babesiosis? Findings  In this multicenter cohort study of 629 patients hospitalized with severe b...

Original Investigation  Changes in Nonprofit Hospitals’ Finances, Operations, and Quality of Care After Using Management Consultants Joseph Dov Bruch, Cal Chengqi Fang, Yan Bo Zeng, et al JAMA Published Online: May 4, 2026 doi: 10.1001/jama.2026.5027 Key Points Question  How much do nonprofit hospitals spend on management consultants, and following the initiation of a management consulting contr...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE OPEN ACCESS ~ Narrative Review Temperature control in acute brain injuryLavinio, A., Busl, K.M., Coles, J.P. et al. OBESITY IN THE ICU What's New in Intensive Care Gaps or paradoxes in clinical responses in obese patientsHernández, G., Muñiz Albaiceta, G. & Thille, A.W. LATEST ARTICLES Original Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults w...