Blood Transcriptomic Framework for Sepsis In Sepsis Wed, 8 Oct 2025 For decades, progress in developing new treatments for critical illnesses such as sepsis, acute respiratory distress syndrome (ARDS), and trauma has been stalled by one fundamental challenge: although these conditions are treated as single diseases, every patient’s body responds differently. This heterogeneity has been a major barrier to advancing care. Two new studies now confront ...

Original Investigation  Pediatrics Screen Time and Standardized Academic Achievement Tests in Elementary School Xuedi Li, Charles D. Keown-Stoneman, Jessica A. Omand, et al JAMA Netw Open 2025;8;(10):e2537092. doi:10.1001/jamanetworkopen.2025.37092 Key Points Question  Is there an association between different types of screen time in young children and academic achievement in grades 3 and 6, as measured b...

Models of Post-ICU Clinics In ICU Wed, 8 Oct 2025 Advances in critical care have shifted the focus from survival alone to enhancing long-term recovery and quality of life for patients and their families. Post-Intensive Care Syndrome (PICS) encompasses persistent physical, cognitive, and psychological problems that emerge after critical illness. To address these issues, several supportive strategies have been developed, including nurse navigators, pulmo...

Original Investigation Integrating Multi-Modal Imaging Features for Early Prediction of Acute Kidney Injury in Pneumonia Sepsis: A Multicenter Retrospective Study Yiding Gu, Langjun Li, Keyi Yang, et al Acad Radiol Available online 29 September 2025 https://doi.org/10.1016/j.acra.2025.08.007 Rationale and Objectives Sepsis, a severe complication of infection, often leads to acute kidney injury (AKI), which significantly increases the risk of death. Despite ...

NEWS 01 August 2024 ‘Publish or Perish’ is now a card game — not just an academic’s life By Max Kozlov Nature 632, 483 (2024) doi: https://doi.org/10.1038/d41586-024-02511-5 A player wins by racking up more citations than the competition, even if that means engaging in a little light plagiarism. Fabricating data, throwing academic shade at other scientists, publishing a mountain of papers that receive a towering heap of citations: cynics might desc...

DATASETS, BENCHMARKS, AND PROTOCOLS Assessment of Large Language Models in Clinical Reasoning: A Novel Benchmarking Study Liam G. McCoy, Rajiv Swamy, Nidhish Sagar, et al NEJM AI 2025;2(10) Published September 25, 2025 DOI: 10.1056/AIdbp2500120 Abstract BACKGROUND Large language models (LLMs) are increasingly deployed for clinical decision support, yet standard evaluations such as medical licensing exams overloo...

Medical News  Research of the Year 2025 Jennifer Abbasi; Samantha Anderer; Rita Rubin, et al JAMA Published Online: December 12, 2025 doi: 10.1001/jama.2025.20503 For this inaugural Research of the Year roundup, JAMA Medical News asked the journal’s top editors to nominate their favorite studies published in JAMA over the past year—the articles that they thought were the most impactful, the most newsworthy, ...

Digital Twins to Assess VILI Risk in APRV vs PCV In ICU Wed, 8 Oct 2025 Airway pressure release ventilation (APRV) delivers continuous positive airway pressure with periodic releases to facilitate CO₂ removal. It has been proposed both as an early intervention to reduce ventilator-induced lung injury (VILI) and as a rescue strategy for acute respiratory distress syndrome (ARDS). APRV may improve lung homogeneity, alveolar recruitment, and gas exchange,...

Original Investigation  Pediatrics Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis João Pedro Lima, Saifur R. Chowdhury, Wimonchat Tangamornsuksan, et al JAMA Netw Open 2025;8;(9):e2534953. doi:10.1001/jamanetworkopen.2025.34953 Key Points Question  What adverse events are associated with the use of systemic corticosteroi...

Original Investigation  Medical Education Variation in Research Experiences and Publications During Medical School by Sex and Race and Ethnicity Mytien Nguyen, Sarwat I. Chaudhry, Emmanuella Asabor, et al JAMA Netw Open 2022;5;(10):e2238520. doi:10.1001/jamanetworkopen.2022.38520 Key Points Question  Are student sex and racial and ethnic identity associated with publication rate during medical school? ...