Consensus Statement  Pediatrics June 14, 2024 Clinical Practice Guideline for Red Blood Cell Transfusion Thresholds in Very Preterm Neonates Emöke Deschmann, Christof Dame, Martha C. Sola-Visner, et al JAMA Netw Open. 2024;7(6):e2417431. doi:10.1001/jamanetworkopen.2024.17431 Abstract Importance  Red blood cell (RBC) transfusion is a common medical intervention to treat anemia in very pret...

Blood culture-free ultra-rapid antimicrobial susceptibility testing. Kim, T.H., Kang, J., Jang, H. et al. Nature (2024). https://doi.org/10.1038/s41586-024-07725-1 Abstract Treatment assessment and patient outcome for sepsis depend predominantly on the timely administration of appropriate antibiotics1,2,3. However, the clinical protocols used to stratify and select patient-specific optimal therapy are extremely slow4. In particular, the major hurdle in perform...

Intravenous Landiolol: Rate Control in Supraventricular Tachyarrhythmias in Patients with LVD In ICU Fri, 17 May 2024 ICU Management & Practice, Volume 24 - Issue 3, 2024 Athina Nasoufidou Second Department of Cardiology Aristotle University of Thessaloniki Hippokration General Hospital Thessaloniki, Greece A systematic review investigating landiolol's efficacy in non-septic or post-operated SVT patients with concomitant left ventricular...

ARTICLES|ONLINE FIRST Effectiveness of ferritin-guided donation intervals in whole-blood donors in the Netherlands (FIND'EM): a stepped-wedge cluster-randomised trial Amber Meulenbeld, Steven Ramondt, Maike G Sweegers, et al Lancet Published: June 13, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)01085-7 Summary Background Whole-blood donors are at increased risk for iron deficiency and anaemia. The current standard of haemoglobin monitoring is insu...

Original Investigation  April 3, 2024 Disparities in Mentorship and Implications for US Surgical Resident Education and Wellness Casey M. Silver, Tarik K. Yuce, Callisia N. Clarke, et al JAMA Surg. 2024;159(6):687-695. doi:10.1001/jamasurg.2024.0533 Key Points Question  What resident characteristics are associated with report of meaningful mentorship, and what is the association between mentorship and res...

ARTICLES| VOLUME 404, ISSUE 10453, P670-682, AUGUST 17, 2024 Hypothermic oxygenated perfusion of the donor heart in heart transplantation: the short-term outcome from a randomised, controlled, open-label, multicentre clinical trial Filip Rega, Guillaume Lebreton, Marylou Para, et al Lancet 2024; 404: 670-682 Published:August 17, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)01078-X Summary Background Static cold storage (SCS) remains the gold standa...

ASTER Trial: Acetaminophen and Organ Dysfunction in Patients With Sepsis In Sepsis Wed, 22 May 2024 Acetaminophen (paracetamol) has several pharmacological effects that are potentially beneficial in sepsis, including analgesia, antipyresis, and cyclooxygenase-2 inhibition. Observational studies and small clinical trials suggest acetaminophen improves survival and kidney function in sepsis patients with elevated cell-free haemoglobin. However, a&nb...

COMMENT|ONLINE FIRST Global Burden of Disease Study 2021 estimates: implications for health policy and research Zachary J Ward, Sue J Goldie Lancet Published: April 17, 2024 DOI: https://doi.org/10.1016/S0140-6736(24)00812-2 Over the past three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has produced several iterations of global estimates for various disease metrics.1 The latest iteration, GBD 2021, published in ...

ARTICLES| VOLUME 404, ISSUE 10453, P659-669, AUGUST 17, 2024 Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands Julia L M Bels, Steven Thiessen, Rob J J van Gassel, et al Lancet 2024; 404: 659-669 Published: August 17, 2024 DOI:https://doi.org/10.1016/S0140-6736(24)013...

ESICM/NACCS Recommendations: Targeted Temperature Control Following TBI In ICU Wed, 22 May 2024 Traumatic brain injury (TBI) is a highly prevalent global health issue, causing significant mortality and disability. It results from external forces affecting brain function or structure. TBI involves primary damage from the initial impact, followed by secondary injury processes such as ischaemia, swelling, and metabolic changes, which worsen outc...