Guidelines: Antibiotic Prophylaxis in Trauma In ICU Tue, 2 Apr 2024 Antibiotic prophylaxis (AP) in surgery prevents surgical site infections (SSIs). Despite clear recommendations from health authorities, AP is often misused globally, leading to reduced patient safety and increased antimicrobial resistance. Factors contributing to inappropriate AP use include errors in drug selection, dosage, duration, timing, and administration method.  In poly...

1‑h Bundle and Mortality in Patients With Suspected Sepsis In Sepsis Wed, 3 Jul 2024 Sepsis and septic shock, caused by a dysregulated response to infection, affect nearly 50 million people globally, resulting in approximately 11 million deaths. Early identification and management, including source control, antimicrobial therapy, and fluid resuscitation, are associated with reduced mortality. The Surviving Sepsis Campaign (SSC) recommends a sepsis bund...

Original Investigation  Cardiology August 6, 2024 Barriers to Optimal Clinician Guideline Adherence in Management of Markedly Elevated Blood Pressure: A Qualitative Study Yuan Lu, Oreoluwa Arowojolu, Xiaoliang Qiu, et al JAMA Netw Open. 2024;7(8):e2426135. doi:10.1001/jamanetworkopen.2024.26135 Key Points Question  What are the plausible scenarios and factors contributing to clinician nonadhe...

Original Investigation  Nutrition, Obesity, and Exercise August 7, 2024 Protein Intake and Mortality in Older Adults With Chronic Kidney Disease Adrián Carballo-Casla, Carla Maria Avesani, Giorgi Beridze, et al JAMA Netw Open. 2024;7(8):e2426577. doi:10.1001/jamanetworkopen.2024.26577 Key Points Question  What are the associations of total, animal, and plant protein intake with all-cause mort...

Tele-Critical Care Nursing: The Well-Established Predecessor of Today’s Virtual Nursing Cited more than 100 times in other publications, A Second Set of Eyes: An Introduction to Tele-ICU was published by Susan Goran in 2010 (Goran 2010). Goran described “the tele-ICU is that ‘second set of eyes’ that provides additional clinical surveillance and support”. She went on to explain how inadequate nurse staffing was “linked to medication errors, increased risk of ...

Inflammatory Subphenotype and Brain Dysfunction in Mechanically Ventilated Patients In ICU Wed, 3 Jul 2024 Up to 80% of mechanically ventilated ICU patients experience acute brain dysfunction, commonly manifesting as delirium or coma. Both conditions are linked to increased mortality and long-term cognitive impairment in survivors. The underlying pathophysiology of acute brain dysfunction during respiratory failure is poorly understood.  Previo...

Original Investigation  Medical Education August 7, 2024 Crowdsourced Feedback to Improve Resident Physician Error Disclosure Skills: A Randomized Clinical Trial Andrew A. White, Ann M. King, Angelo E. D’Addario, et al JAMA Netw Open. 2024;7(8):e2425923. doi:10.1001/jamanetworkopen.2024.25923 Key Points Question  Is crowdsourced feedback from laypeople an effective educational intervention to improve resident physicians’ error...

Novel Lipopeptide Effective Against Staphylococcus Aureus In ICU Fri, 7 Jun 2024 A novel antibacterial lipopeptide produced by the bacterium Serratia marcescens is highly effective in killing Staphylococcus aureus, one of the most significant pathogens in humans. Staphylococcus aureus is among the five most common causes of hospital-acquired infections, often leading to life-threatening infections following surgery. Since the int...

Original Investigation  Critical Care Medicine August 7, 2024 Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis Theresa Shu Wen Toh, Pravin R. R., Karen Hwee Ying Ho, et al JAMA Netw Open. 2024;7(8):e2426225. doi:10.1001/jamanetworkopen.2024.26225 Key Points Question  Does daily sedation interruptio...

Sex Differences in SOFA Score of Sepsis Patients In Sepsis Tue, 2 Jul 2024 Sepsis is a life-threatening condition caused by a dysregulated host response to infection. The Sepsis-related Organ Failure Assessment (SOFA) score, developed in 1996, quantifies organ dysfunction across six systems: neurological, cardiovascular, respiratory, renal, liver, and coagulation. Initially specific to sepsis, the SOFA score is widely used in ICUs for daily patient mon...