Original Investigation  Surgery Surgeon Volume and Clinical Outcomes After Robotic Elective and Emergency General Surgery Natasha Houshmand, I-Fan Shih, Alistair J. Kent, et al JAMA Netw Open 2026;9;(5):e2611774. doi:10.1001/jamanetworkopen.2026.11774 Key Points Question  Is annual surgeon robotic case volume associated with outcomes for both elective and emergency robotic general surgery procedures? F...

Editorial  Dapagliflozin to Reduce the Risk of Perioperative Acute Kidney Injury in Elective Cardiac Surgery Wolfgang C. Winkelmayer, Glenn M. Chertow JAMA Published Online: July 30, 2026 doi: 10.1001/jama.2026.7477 Sodium-glucose cotransporter 2 (SGLT2) inhibitors have constituted a major advancement for the treatment of patients with chronic kidney disease and/or heart failure, with sizeable benefits in reducing progression of kidney disease and in r...

Editorial  The Price of Advice—Do Management Consultants Deliver Value to Nonprofit Hospitals? Thomas C. Buchmueller, Helen G. Levy JAMA Published Online: May 4, 2026 doi: 10.1001/jama.2026.4362 In a well-publicized case that stoked public outrage, Providence, a nonprofit health system headquartered in the state of Washington, implemented a program in 2018 called Rev Up to increase revenue collection from patients.1 Following enforcement action by the ...

Original Investigation  Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial Maartina J. P. Oosterom-Eijmael, Abraham H. Hulst, Nelson P. Monteiro de Oliveira, et al JAMA Published Online: July 30, 2026 doi: 10.1001/jama.2026.9268 Key Points Question  Among patients undergoing elective cardiac surgery, does dapagliflozin, initiated 1 day prior to surgery, reduce acute kidney injury at 7 days after su...

R2D2-ICU: Restrictive vs Liberal Physical Restraint Strategies In ICU Tue, 17 Mar 2026 Findings from the Restrictive Use of Restraints and Delirium Duration in ICU (R2D2-ICU) trial were presented at the 45th ISICEM in Brussels. The trial investigated whether a restrictive (low-use) versus liberal (high-use) wrist-strap physical restraint strategy improves outcomes in critically ill adults receiving invasive mechanical ventilation. Physical restraint...

Original Investigation  Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis Kevin Damman, Dirk J. van Veldhuisen, Johann Bauersachs, et al JAMA Published Online: May 10, 2026 doi: 10.1001/jama.2026.7886 Key Points Question  What are the effects of digitalis glycoside treatment on cardiovascular death and worsening heart failure (HF) events in patients with HF with mildl...

Invited Commentary  Health Informatics Limitations of Large Language Models in Clinical Diagnostic Reasoning Mickael Tordjman, Xueyan Mei JAMA Netw Open 2026;9;(4):e264014. doi:10.1001/jamanetworkopen.2026.4014 Large language models (LLMs) have rapidly gained an important role in multiple fields, including medicine. These widely available tools can enhance patient understanding, improve physician productivity, and provide encyclopedic knowledge on seve...

Original Investigation  Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial Ganesan Karthikeyan, Niveditha Devasenapathy, Arpita Ghosh, et al JAMA Published Online: May 10, 2026 doi: 10.1001/jama.2026.7335 Key Points Question  Does digoxin, compared with placebo, reduce the composite of all-cause death or new-onset or worsening heart failure in symptomatic r...

CORRESPONDENCE Reducing Bacterial Contamination of Blood Bags with a Double Knot Kathleen Selleng, Halima Ismail, Christian Kohler, et al N Engl J Med 2026;394:1865-1866 DOI: 10.1056/NEJMc2600589 TO THE EDITOR: Bacterial contamination of blood for transfusions poses a serious risk to patients, particularly in resource-limited settings.1 Blood centers in high-income nations use heat-sealed tubing to close blood bags after donation; however, these too...

Editorial  Prone Positioning in Viral Bronchiolitis—Back to the Back? Joseph G. Kohne, Susan R. Conway, Steven L. Shein JAMA 2026;336;(4):290-292. doi:10.1001/jama.2026.11742 Acute viral bronchiolitis is the most common diagnosis in US children’s hospitals, and respiratory failure is the costliest diagnosis across all pediatric acute care.1 Despite the prevalence of this condition and its impact on children, families, and health systems, evidence-based tr...