CLINICAL INVESTIGATION Targeted Tissue Perfusion Versus Macrocirculatory-Guided Standard Care in Patients With Septic Shock: A Randomized Clinical Trial—The TARTARE-2S Trial Pettilä, Ville; Pfortmüller, Carmen A; Perner, Anders; et al Critical Care Medicine 54(1):p 24-34, January 2026. | DOI: 10.1097/CCM.0000000000006899 Abstract Objectives:  To determine whether treatment targeting improving tissue perfusion while allowing lower than recommende...

Music-Listening Intervention & Delirium/Coma-Free Days in Patients Undergoing Mechanical Ventilation In ICU Thu, 16 Oct 2025 A multi-centre randomised controlled trial of critically ill adults aged 50 years and older admitted to ICUs found that twice-daily slow-tempo music (60–80 beats per minute) did not reduce the duration or severity of delirium or coma, nor did it lessen pain or anxiety compared with a silence-track control. While the interv...

Original Investigation  Effectiveness and Cost-Effectiveness of Automated External Defibrillators in Private Homes: A Report From the Cardiac Arrest Registry to Enhance Survival Lars W. Andersen, Mathias J. Holmberg, Eline Krijkamp, et al JAMA Intern Med 2026;186;(1):37-43. doi:10.1001/jamainternmed.2025.6123 Key Points Question  Are automated external defibrillations (AEDs) in private homes effective and co...

ONLINE FIRST (FREE ACCESS) MY GREEN ICU Correspondence Integrating sustainability into critical care undergraduate education: preparing future physicians for a climate-conscious practice. Author's replyBoissier, F., Poissy, J., Lecronier, M. et al. STANDARD OF CARE IN THE INTENSIVE CARE UNIT Editorial Stepwise fluid management in critical illnessMekontso Dessap, A., Cecconi, M. LATEST ARTICLES EditorialChecking methodology and statistics when readi...

Original Investigation  Emergency Medicine Ketamine, Etomidate, and Mortality in Emergency Department Intubations Ian Ward A. Maia, Sérgio R. R. Decker, Lucas Oliveira J. e Silva, et al JAMA Netw Open 2025;8;(12):e2548060. doi:10.1001/jamanetworkopen.2025.48060 Key Points Question  Among critically ill adults undergoing rapid sequence intubation, is etomidate use associated with higher in-hospital mortali...

Original Investigation  Critical Care Medicine Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients Feng Xie, Yifan Yao, Yue Ma, et al JAMA Netw Open 2025;8;(12):e2552771. doi:10.1001/jamanetworkopen.2025.52771 Key Points Question  Is daily intravenous pantoprazole cost-effective in preventing upper gastrointestinal bleeding in mechanically vent...

Immune Dysregulation Framework for Sepsis and Critical IllnessesIn SepsisThu, 2 Oct 2025 When a critically ill patient arrives in the emergency department, physicians must make rapid, high-stakes decisions related to infection and whether that infection is bacterial or viral. There are decisions related to whether the patient needs immediate treatment, and whether they can recover safely at home or must be admitted.  Even once an infection is identified, tr...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT What's New in Intensive Care Ten ethical challenges in donation after circulatory death (DCD): a practical guide for intensivistsVergano, M., Metaxa, V. & Citerio, G. LATEST ARTICLES OriginalTrends in renal replacement therapy use in intensive care unit: insights from a French multicenter cohortSchmidt, J., Grimaldi, L., Martel, P. et al. OPEN ACCESS ~ Original Temporal ro...

Original Investigation  Less Is More Antibiotic De-Escalation in Adults Hospitalized for Community-Onset Sepsis Ashwin B. Gupta, Megan Heath, Emily Walzl, et al JAMA Intern Med Published Online: December 22, 2025 doi: 10.1001/jamainternmed.2025.6919 Key Points Question  Is broad-spectrum antibiotic de-escalation on encounter day 4 safe among patients hospitalized with community-onset sepsis w...

Original Investigation  Surgery β-Lactam vs Non–β-Lactam Antimicrobial Prophylaxis and Surgical Site Infection Selina Largiadèr, Delphine Berthod, Andreas Widmer, et al JAMA Netw Open 2025;8;(10):e2540809. doi:10.1001/jamanetworkopen.2025.40809 Key Points Question  Is the administration of non–β-lactam surgical antimicrobial prophylaxis (SAP) vs β-lactam SAP associated with increased surgical site infecti...