Comment Testing early haemostatic therapy for acute intracerebral haemorrhage Craig S Anderson, Chen Chen, Rustam Al-Shahi Salman Lancet Available online 4 February 2026 https://doi.org/10.1016/S0140-6736(26)00146-7 The clinical severity, narrow time window to reduce bleeding, and variable care pathways for patients with spontaneous (non-traumatic) intracerebral haemorrhage (ICH) are enormous challenges to be overcome by treatments for this serious conditio...

Original Investigation  Critical Care Medicine Physician Variation in Early Sepsis Management Ithan D. Peltan, Danielle Groat, Jorie Butler, et al JAMA Netw Open 2026;9;(2):e2556945. doi:10.1001/jamanetworkopen.2025.56945 Key Points Question  Are sepsis treatment practice patterns characterized by faster antimicrobial initiation associated with increased overtreatment, and what are their mechanisms? Fi...

Article Health outcomes according to severity of acute kidney injury at ICU admission: a population-based cohort study Hundemer, G.L., Dumicho, A.Y., Knoll, G.A. et al. Intensive Care Med(2026). Published: 05 February 2026 https://doi.org/10.1007/s00134-026-08317-5 Abstract Purpose The presence and severity of acute kidney injury (AKI) upon ICU admission provides important short- and long-term prognostic information. Existing reports have been limited...

Positive Communication Programme Cuts ICU Staff Burnout  In ICU Sun, 9 Nov 2025 Burnout among intensive care unit (ICU) professionals remains a persistent concern, with earlier reports indicating levels approaching 60% in these settings. The Hello trial tested whether a pragmatic, unit-wide programme designed to support organisational culture and team climate could reduce burnout across a broad int...

Articles Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial Joseph P Broderick, Andrew M Naidech, Jordan J Elm, et al Lancet Available online 4 February 2026 https://doi.org/10.1016/S0140-6736(26)00097-8 Summary Background Recombinant factor VIIa has been shown to slow bleeding in patients with intracerebral h...

Article The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial) Tangjitaree, P., Thanapongsatorn, P., Sinjira, T. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08302-y Abstract Background The estimated incidence of acute kidney injury requiring renal replacement ...

HUMANITIES: ORIGINAL RESEARCHVolume 169, Issue 2P486-495February 2026 Post-Intensive Care Syndrome Awareness and Communication: Surveys of ICU Providers and Patients Mark L. Rolfsen, Matthew F. Mart, Hannah Kieffer, et al Chest 2026; 169: 486-495 DOI: 10.1016/j.chest.2025.08.048 Abstract Background Survivors of critical illness often experience new or worsening impairments in various domains of health after discharge, collectively referred to as post-...

Sex-Based Disparities in Sepsis Treatment  In Sepsis Wed, 5 Nov 2025 Sepsis remains one of the leading causes of death in intensive care units worldwide. Despite significant progress in early detection and management, antibiotic dosing protocols often fail to account for patient-specific factors, particularly those linked to biological sex and gender-related disparities in care.  A new editorial in the Journal of I...

Invited Commentary  Rethinking Failure to Rescue After Anastomotic Leak Cynthia Araradian, Shelby Willis, Sandy H. Fang JAMA Surg Published Online: February 11, 2026 doi: 10.1001/jamasurg.2025.6557 Death after major complications or failure to rescue (FTR) is an important quality safety metric used to measure hospital surgical care, and it affects hospital reimbursement. Anastomotic leak is a severe complication of colorectal surgery that has been link...

Keeping the ARDS Patient Dry In ICU Thu, 19 Mar 2026 Fluid management in acute respiratory distress syndrome (ARDS) remains a complex and evolving area, with no single ‘optimal’ strategy. Discussing this @ISICEM, Prof Daniel De Backer emphasised that while avoiding fluid overload is important, the key challenge is tailoring therapy to the individual patient rather than adhering to rigid ‘dry’ or ‘wet’ approaches. Historically, fluid management in AR...