Transcatheter or Surgical Treatment of Aortic-Valve Stenosis Stefan Blankenberg, Moritz Seiffert, Reinhard Vonthein, et al N Engl J Med 2024;390:1572-1583 DOI: 10.1056/NEJMoa2400685 Abstract BACKGROUND Among low-risk patients with severe, symptomatic aortic stenosis who are eligible for both transcatheter aortic-valve implantation (TAVI) and surgical aortic-valve replacement (SAVR), data are lacking on the appropriate treatment strategy in routine clinic...

Nasal Microbiota - Potential Diagnostic Biomarker for Sepsis In Sepsis Thu, 13 Jun 2024 A new study published in Microbiology Spectrum reveals that the nasal microbiota of ICU patients can effectively distinguish between sepsis and non-sepsis cases, outperforming gut microbiota in predicting sepsis. These findings have implications for developing diagnostic strategies and advancing critical care medicine. Historically, the focus has been more on the...

ARTICLES|ONLINE FIRST Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV) Phrutsamon Wongnak, William H K Schilling, Podjanee Jittamala, et al Lancet Infect Dis Published: April 24, 2024 DOI: https://doi.org/10.1016/S1473-3099(24)00183-X Summary Background Effective antiviral drugs prevent h...

Invited Commentary  August 7, 2024 Surgeon Type and Anastomotic Leaks in Ovarian Cancer Alexandra C. Istl, Nerlyne Desravines, Ugwuji N. Maduekwe JAMA Surg. Published online August 7, 2024. doi:10.1001/jamasurg.2024.2929 For patients with advanced ovarian cancer, cytoreductive surgery (CRS) and platinum-based chemotherapy are pillars of treatment.1 Optimal completeness of cytoreduction, which may necessitate multivisceral resections, aim...

Clinical Review State of the Art Review Device associated complications in the intensive care unit Roxana Hixson, Kristin Schwab Jensen, Kathryn H Melamed, et al BMJ 2024; 386 doi: https://doi.org/10.1136/bmj-2023-077318 (Published 13 August 2024)Cite this as: BMJ 2024;386:e077318 Abstract Invasive devices are routinely used in the care of critically ill patients. Although they are often essential components of p...

CENTER-TBI - Haemoglobin Values, Transfusion Practices, Outcomes In ICU Wed, 19 Jun 2024 Severe traumatic brain injury (TBI) can cause lasting cognitive, motor, and emotional issues. Despite advances in emergency care and neurosurgery, the long-term effects of TBI remain challenging for patients, caregivers, and healthcare providers. Managing TBI focuses on preventing secondary brain injuries, which can develop hours to days after the initial trauma...

Research Intraosseous versus intravenous vascular access in upper extremity among adults with out-of-hospital cardiac arrest: cluster randomised clinical trial (VICTOR trial) Ying-Chih Ko, Hao-Yang Lin, Edward Pei-Chuan Huang, et al BMJ 2024; 386 doi: https://doi.org/10.1136/bmj-2024-079878 (Published 23 July 2024)Cite this as: BMJ 2024;386:e079878 Abstract Objective To compare the effectiveness of intraosseous v...

Original Investigation  August 7, 2024 Bowel Resection Outcomes in Ovarian Cancer Cytoreductive Surgery by Surgeon Specialty Jasmine Ebott, Phinnara Has, Christina Raker, et al JAMA Surg. Published online August 7, 2024. doi:10.1001/jamasurg.2024.2924 Key Points Question  Stratified by surgeon type, what are the surgical outcomes for patients with ovarian cancer who undergo a bowel resection dur...

Invited Commentary  August 7, 2024 Is Too Much Oxygen a Bad Thing? Bryant Fisher, Kathirvel Subramaniam, Danny Chu JAMA Surg. Published online August 7, 2024. doi:10.1001/jamasurg.2024.2921 The current referenced double-blind randomized clinical trial by Lopez and others1 compared strategies of intraoperative hyperoxia vs normoxia during elective cardiac surgery to assess the impact on oxidative stress and clinical markers of end-organ d...

Original Investigation  August 7, 2024 Intraoperative Oxygen Treatment, Oxidative Stress, and Organ Injury Following Cardiac Surgery: A Randomized Clinical Trial Marcos G. Lopez, Matthew S. Shotwell, Cassandra Hennessy, et al JAMA Surg. Published online August 7, 2024. doi:10.1001/jamasurg.2024.2906 Key Points Question  Does administration of high concentrations of oxygen (hyperoxia) increase ox...