Editorial  October 9, 2024 Evaluating Complex Technological Innovations in Critical Care—Current Challenges and Future Directions Kelly C. Vranas, Jeremy M. Kahn JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.19854 The benefits of the intensive care unit (ICU) for delivering high-quality care and improving survival for critically ill patients are primarily due to the people who work there—the specialized physicians, nurses, and...

Original Investigation | Caring for the Critically Ill Patient October 9, 2024 Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial Karen E. A. Burns, Jessica Wong, Leena Rizvi, et al JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.20631 Key Points Question  What are the effects of alternative screening frequencies and spontaneous breathing trial (SBT) techniques on the time to s...

EDITORIAL Amino Acid Infusion to Protect Kidney Function after Cardiac Surgery Marlies Ostermann, Andrew D. Shaw N Engl J Med 2024;391:759-760 DOI: 10.1056/NEJMe2408632 Cardiac surgery–associated acute kidney injury (AKI) is linked to adverse outcomes including an increased risk of death, postoperative complications, and higher rates of incident or progressive chronic kidney disease.1,2 The cause of cardiac surgery–associated AKI is multifactorial. It ...

Original Investigation  August 19, 2024 Tranexamic Acid in Patients Undergoing Liver Resection: The HeLiX Randomized Clinical Trial Paul J. Karanicolas, Yulia Lin, Stuart A. McCluskey, et al JAMA. Published online August 19, 2024. doi:10.1001/jama.2024.11783 Key Points Question  Does tranexamic acid reduce red blood cell transfusion within 7 days of liver resection? Findings  In thi...

Original Investigation | Caring for the Critically Ill Patient October 9, 2024 Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial Xosé Pérez-Fernández, Arnau Ulsamer, María Cámara-Rosell, et al JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.20630 Key Points Question  Does the use of a nonselective extracorporeal blood purification (EBP) device connected t...

Editorial  October 9, 2024 Shifting Balance of the Risk-Benefit of Restrictive Transfusion Strategies in Neurocritically Ill Patients—Is Less Still More? Alexis F. Turgeon, François Lauzier JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.20416 Acute neurological injuries, especially traumatic brain injuries and subarachnoid hemorrhages, often affect young and previously healthy patients with years of active life to come. Mortali...

Original Investigation | Caring for the Critically Ill Patient October 9, 2024 Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients: The TELESCOPE Randomized Clinical Trial Adriano J. Pereira, Danilo T. Noritomi, Maura Cristina dos Santos, et al JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.20651 Key Points Question  Is an intensivist-led telemedicine-based strategy including daily multidisciplinary round...

Proton-Pump Inhibitors to Prevent Gastrointestinal Bleeding In ICU Tue, 18 Jun 2024 A recent systematic review evaluated the effectiveness and safety of proton-pump inhibitors (PPIs) for preventing stress ulcers in critically ill patients. The review included randomised trials that compared PPIs with placebo or no prophylaxis in critically ill adults. Meta-analyses were performed, and evidence was assessed using the Grading of Recommendations, Asses...

Original Investigation｜Caring for the Critically Ill Patient October 9, 2024 Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial Fabio Silvio Taccone, Carla Rynkowski Bittencourt, Kirsten Møller, et al JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.20424 Key Points Question  How does use of a liberal or restrictive strat...

Viewpoint  August 8, 2024 Leading Causes of Death in the US, 2019-2023 Farida B. Ahmad, Jodi A. Cisewski, Robert N. Anderson JAMA. Published online August 8, 2024. doi:10.1001/jama.2024.15563 The annual mortality burden, the causes of mortality, and the changes over time are key indicators of population change. In the US, mortality statistics are derived from death certificate data from the National Center for Health Statistics National Vital...