Original Investigation  August 21, 2024 Characterizing Long COVID in Children and Adolescents Rachel S. Gross, Tanayott Thaweethai, Lawrence C. Kleinman, et al JAMA. Published online August 21, 2024. doi:10.1001/jama.2024.12747 Key Points Question  What prolonged symptoms experienced by youth are most associated with SARS-CoV-2 infection? Findings  Among 5367 participants in the REC...

EDITORIAL Why Was the Azithromycin “for Life” Trial Necessary? Kathryn Maitland, A. Sarah Walker N Engl J Med 2024;391:760-762 DOI: 10.1056/NEJMe2407000 In 2009, a cluster-randomized trial showed a 49% reduction in all-cause mortality among Ethiopian children 1 to 9 years of age in the year after mass distribution of a single dose of azithromycin for trachoma prevention — a reduction that was sustained over the following 26 months.1 ...

Research Suicide rates among physicians compared with the general population in studies from 20 countries: gender stratified systematic review and meta-analysis Claudia Zimmermann, Susanne Strohmaier, Harald Herkner, et al BMJ 2024; 386 doi: https://doi.org/10.1136/bmj-2023-078964 (Published 21 August 2024)Cite this as: BMJ 2024;386:e078964 Abstract Objectives To estimate age standardised suicide rate ratios in male and female physicians compared with...

Editorial  October 9, 2024 Ventilator Weaning Strategies—Managing Interaction Between Randomized Treatments Steven A. Webb, Lindsay R. Berry, Ary Serpa Neto JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.19853 Weaning of mechanical ventilation is a critical aspect of care for patients in intensive care units (ICUs). The process of weaning involves the gradual reduction in intensity of ventilatory support sufficient to allow the...

Original Investigation  Physician Work Environment and Well-Being August 26, 2024 Physician EHR Time and Visit Volume Following Adoption of Team-Based Documentation Support Nate C. Apathy, A. Jay Holmgren, Dori A. Cross JAMA Intern Med. Published online August 26, 2024. doi:10.1001/jamainternmed.2024.4123 Key Points Question  How do physician visit volume, documentation time in the electronic heal...

Analysis Wider use of tranexamic acid to reduce surgical bleeding could benefit patients and health systems Ian Roberts, Michael F Murphy, Ramani Moonesinghe, et al BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2024-079444 (Published 12 June 2024) Cite this as: BMJ 2024;385:e079444

Original Investigation  Orthopedics August 23, 2024 Tourniquet Use and Local Tissue Concentrations of Cefazolin During Total Knee Arthroplasty: A Randomized Clinical Trial Julien Montreuil, Michael Tanzer, Yu Ling Zhang, et al JAMA Netw Open. 2024;7(8):e2429702. doi:10.1001/jamanetworkopen.2024.29702 Key Points Question  What is the effect of tourniquet application on local tissue concentrati...

Continuous vs Intermittent β-lactam Antibiotics in Sepsis In Sepsis Sun, 23 Jun 2024 A new study aimed to determine if continuous infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) reduces all-cause mortality at 90 days compared to intermittent infusion in critically ill patients with sepsis. The BLING III randomised clinical trial was conducted across 104 ICUs in Australia, Belgium, France, Malaysia, New Zealand, Sweden, and t...

ORIGINAL ARTICLE Azithromycin to Reduce Mortality — An Adaptive Cluster-Randomized Trial Kieran S. O’Brien, Ahmed M. Arzika, Abdou Amza, et al N Engl J Med 2024;391:699-709 DOI: 10.1056/NEJMoa2312093 Abstract BACKGROUND Twice-yearly mass distribution of azithromycin to children is a promising intervention to reduce childhood mortality in sub-Saharan Africa. The World Health Organization recommended restricting distribution to infants 1 to 11 months of...

Editorial  October 9, 2024 Impact of Adsorptive Blood Purification on Kidney Outcomes Yuenting Diana Kwong, Kathleen D. Liu JAMA. Published online October 9, 2024. doi:10.1001/jama.2024.20928 Acute kidney injury (AKI) is a common complication in hospitalized patients, associated with significant short-term morbidity and mortality, and for which the only current therapeutic strategies are supportive. Of the common causes of AKI, cardiac surger...