ONLINE FIRST (FREE ACCESS) "ICU TOOLBOX" TOPICAL COLECTION Editorial Citrate anticoagulation for continuous renal replacement therapy Honoré P. M., Rimmelé T. and Joannes-Boyau O. How to end quiet suffering in the intensive care unit? Identifying and treating hypoactive deliriumKotfis K., Mesa P. and E. Wesley Ely E. W. "MY GREEN ICU" COLECTION CorrespondenceGreen ICU is good, but not perfect Chen R-X INTENSIVE CARE IN RESOURCE LIMITED SETTINGS ...

Thoracic Oncology: Guidelines and Consensus Statement Management of Central Airway Obstruction: An American College of Chest Physicians Clinical Practice Guideline Kamran Mahmood, Lindsy Frazer-Green, Anne V. Gonzalez, et al Chest 2024 in press https://doi.org/10.1016/j.chest.2024.06.3804 Background Central airway obstruction (CAO), seen in a variety of malignant and non-malignant airway disorders, is associated with a poor prognosis. The management of CAO ...

Hot Topic Session: Frequency of Screening and SBT Techniques In ICU Wed, 9 Oct 2024 Approximately 20 million individuals globally undergo mechanical ventilation each year, and this number is expected to increase. While lifesaving, invasive ventilation can lead to complications, with 40% of ventilated time spent on liberating patients from the ventilator. Reducing the duration of mechanical ventilation is a key research priority for better outcomes. Res...

Original Investigation  Statistics and Research Methods September 6, 2024 Agreement Between Mega-Trials and Smaller Trials: A Systematic Review and Meta-Research Analysis Lum Kastrati, Hamidreza Raeisi-Dehkordi, Erand Llanaj, et al JAMA Netw Open. 2024;7(9):e2432296. doi:10.1001/jamanetworkopen.2024.32296 Key Points Question  Are the results of mega-trials with 10 000 participants or more sim...

ARTICLESVolume 12, Issue 9P714-727September 2024 Estimated number of lives directly saved by COVID-19 vaccination programmes in the WHO European Region from December, 2020, to March, 2023: a retrospective surveillance study Margaux M I Meslé, Jeremy Brown, Piers Mook, et al Lancet Respir Med 2024; 12: 714-727 Summary Background By March, 2023, 54 countries, areas, and territories (hereafter CAT) in the WHO European Regi...

Disease Outbreak News Antimicrobial Resistance, Hypervirulent Klebsiella pneumoniae - Global situation 31 July 2024 WHO risk assessment Globally, there is no systematic surveillance that allows for the routine identification and information collection of hvKp strains. Identification of hvKp is challenging given that it is determined by available laboratory capacity to perform genomic sequencing tests or analysis of specific markers that may indicate hypervirul...

HELLO Trial: Enhancing Interpersonal Relationships Among ICU Healthcare Professionals In ICU Tue, 8 Oct 2024 Burnout among healthcare professionals, especially in ICUs, is marked by emotional exhaustion, depersonalisation, and reduced personal accomplishment, significantly impacting staff well-being and patient care. It leads to decreased job satisfaction, higher turnover rates, recruitment challenges, and poor team dynamics, which can compromise patie...

ARTICLESOnline first100894August 22, 2024Open Access Early warning COVID-19 outbreak in long-term care facilities using wastewater surveillance: correlation, prediction, and interaction with clinical and serological statuses Xiaoli Pang, Bonita E Lee, Tiejun Gao, et al Lancet Microbe 2024 https://doi.org/10.1016/S2666-5247(24)00126-5 Summary Background The unprecedented COVID-19 pandemic has highlighted the strategic value of wastewater-based surveillanc...

ARTICLESVolume 5, Issue 9100864 September 2024 Open Access Association between butyrate-producing gut bacteria and the risk of infectious disease hospitalisation: results from two observational, population-based microbiome studies Robert F J Kullberg, Irina Wikki, Bastiaan W Haak, et al Lancet Microbe 2024; 5: 10086 Summary Background Microbiota alterations are common in patients hospitalised for severe infections, and preclinical models have shown that ...

Disease Outbreak NewsAntimicrobial Resistance, Hypervirulent Klebsiella pneumoniae - Global situation31 July 2024 Situation at a glance In early 2024, the Global Antimicrobial Resistance and Surveillance System on Emerging Antimicrobial Resistance Reporting (GLASS-EAR) issued a request for information to assess the current global situation given the increased identification of isolates of hypervirulent Klebsiella pneumoniae (hvKp) sequence type (ST) 23 carrying re...